Alpha‐frequency synchronization deficits during life predict postmortem neurofibrillary tangle burden in Alzheimer’s disease

Using a multimodal imaging approach with neurophysiological assessments incorporated alongside molecular markers in patients with AD, we have previously demonstrated frequency‐specific neural synchronization deficits distinctly associated with tau and Aβ tracer uptake. Reduced alpha (8‐12 Hz) synchrony (alpha hyposynchrony) closely mapped onto regional patterns of tau uptake and was modulated by the degree of tau uptake. In contrast, increased delta‐theta (2‐8 Hz) synchrony (delta‐theta hypersynchrony) showed strong associations with Aβ tracer uptake. Here, we examined the associations between regional neurofibrillary tangle (NFT) pathology and frequency‐specific neuronal synchrony in patients with AD.