The neuranatomical basis of central control of cardiorespiratory interactions in vertebrates.

It seems that a dual location for vagal preganglionic neurones (VPNs) has important functional correlates in all vertebrates. This may be particularly the case with the central control exerted over the heart by cardiac VPNs (CVPNs). About 30% of VPNs but up to 70% of CVPNs are in the nucleus ambiguus (NA) of mammals. There is a similar proportional representation of VPNs between the major vagal nuclei in amphibians and turtles but in fish and crocodilians the proportion of VPNs in the NA is closer to 10% and in some lizards and birds it is about 5%. However, the CVPNs are distributed unequally between these nuclei so that 45 %O of the CVPNs are located in the NA of the dogfish, and about 30% in the NA of Xenopus and the duck. This topographical separation of CVPNs seems to be of importance in the central control of the heart. Cells in one location may show respiration-related activity (e.g those in the dorsal vagal nucleus (DVN) of dogfish and in the NA of mammals) while cells in the other locations do not. Their different activities and separate functions will be determined by their different afferent inputs from the periphery or from elsewhere in the CNS, which in turn will relate to their central topography. Thus, CVPNs in the NA of mammals receive inhibitory inputs from neighbouring inspiratory neurones, causing respiratory sinus arrythmia (RSA), and the CVPNs in the DVN of the dogfish may generate cardiorespiratory synchrony (CRS).

[1]  P. Butler,et al.  Factors affecting the respiratory and cardiovascular responses to hypercapnic hypoxia, in mallard ducks. , 1983, Respiration physiology.

[2]  E. Taylor,et al.  Spontaneous efferent activity in branches of the vagus nerve controlling heart rate and ventilation in the dogfish. , 1985, The Journal of experimental biology.

[3]  W. Burggren.  Central Cardiovascular Function in Amphibians: Qualitative Influences of Phylogeny, Ontogeny, and Season , 1995 .

[4]  J. Altimiras,et al.  Ontogeny of cholinergic and adrenergic cardiovascular regulation in the domestic chicken (Gallus gallus). , 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

[5]  D. Black.  The motor nuclei of the cerebral nerves in phylogeny: A study of the phenomena of neurobiotaxis part I. Cyclostomi and pisces , 1917 .

[6]  S. Molloi,et al.  The mechanism of cardiac shunting in reptiles: a new synthesis. , 1996, The Journal of experimental biology.

[7]  W. F. Windle.  Neurofibrillar development in the central nervous system of cat embryos between 8 and 12 mm. long , 1933 .

[8]  M. Hedrick,et al.  Control and interaction of the cardiovascular and respiratory systems in anuran amphibians. , 1999, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.

[9]  Catherine R. Thompson,et al.  Heart rate variability in healthy term newborns: the contribution of respiratory sinus arrhythmia. , 1993, Early human development.

[10]  C. Kidd,et al.  A horseradish peroxidase study of vagal motoneurones with axons in cardiac and pulmonary branches of the cat and dog. , 1981, Quarterly journal of experimental physiology.

[11]  J. Hicks.  Adrenergic and Cholinergic Regulation of Intracardiac Shunting , 1994, Physiological Zoology.

[12]  D. Jordan,et al.  Activity of cardiac vagal preganglionic neurones during the pulmonary chemoreflex in the anaesthetized cat. , 1994, Advances in experimental medicine and biology.

[13]  E. Taylor,et al.  The characteristics of cardiac vagal preganglionic motoneurones in the dogfish. , 1985, The Journal of experimental biology.

[14]  E. Taylor,et al.  The location of cardiac vagal preganglionic neurones in the brain stem of the dogfish Scyliorhinus canicula. , 1985, The Journal of experimental biology.

[15]  E. Taylor.  6 Nervous Control of the Heart and Cardiorespiratory Interactions , 1992 .

[16]  E. Taylor.  The evolution of efferent vagal control of the heart in vertebrates. , 1994, Cardioscience.

[17]  C. S. S.,et al.  The Comparative Anatomy of the Nervous System of Vertebrates, including Man , 1937, Nature.

[18]  D. Jordan,et al.  Synaptic mechanisms involved in the inspiratory modulation of vagal cardio‐inhibitory neurones in the cat. , 1984, The Journal of physiology.

[19]  Y. Ihmied.  Relocation of preganglionic vagal motoneurones in the brain stem of the axolotl at metamorphosis , 1992 .

[20]  P. Butler.  Respiratory and cardiovascular control during diving in birds and mammals. , 1982, The Journal of experimental biology.

[21]  H. Karten,et al.  Topographic representation of visceral target organs within the dorsal motor nucleus of the vagus nerve of the pigeon Columba livia , 1985, The Journal of comparative neurology.

[22]  S. Leong,et al.  The localization of vagal neurons in the terrapin (Trionyx sinensis) as revealed by the retrograde horseradish peroxidase method. , 1984, Journal of the autonomic nervous system.

[23]  P. Butler,et al.  Nervous control of heart rate: activity in the cardiac vagus of the dogfish. , 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

[24]  S. Nilsson.  3 Innervation and Pharmacology of the Gills , 1984 .

[25]  E. W. Taylor,et al.  Comparative Physiology , 2001, The Journal of physiology.

[26]  P. Butler,et al.  The central localization of the vagus nerve in the ferret (Mustela putorius furo) and the mink (Mustela vison). , 1993, Journal of the Autonomic Nervous System.

[27]  E. Taylor.  Control and co-ordination of gill ventilation and perfusion. , 1985, Symposia of the Society for Experimental Biology.

[28]  D Jordan,et al.  Activity of C fibre cardiac vagal efferents in anaesthetized cats and rats , 1998, The Journal of physiology.

[29]  S. Warburton,et al.  Vagal control of heart rate and cardiac shunts in reptiles: relation to metabolic state. , 2001, Experimental physiology.

[30]  David R. Jones,et al.  Physiology of diving of birds and mammals. , 1997, Physiological reviews.

[31]  D Jordan,et al.  Central control of the cardiovascular and respiratory systems and their interactions in vertebrates. , 1999, Physiological reviews.