In vivo Retention Time Evaluation of Polyethylene Glycol Suppository Bases

AbstractNinety six (96) healthy male volunteers between the ages of 21 and 35 received two experimental polyethylene glycol suppository bases and one commercially available base. A comparison of the two experimental bases with the commercially available base indicates that the base containing polyethylene glycol 1000-4000 (65:35) is superior and that the base containing polyethylene glycol 1540-6000 (30:70) is probably comparable to the commercial product. It is concluded that these polyethylene glycols can be used as suppository bases without undue reaction.

[1]  A. Guida,et al.  Suppository bases. I. An evaluation of the rates of release of theophylline. , 1953, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

[2]  J. Borzelleca,et al.  Drug absorption from the rectum. 3. Asprin and some aspirin derivatives. , 1970, Journal of pharmaceutical sciences.

[3]  S. Riegelman,et al.  The kinetics of rectal absorption. I. Preliminary investigations into the absorption rate process. , 1958, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.

[4]  H. Gross,et al.  A study of suppository bases. II. A colorimetric method for measuring medicinal release from suppository bases. , 1953, Journal of the American Pharmaceutical Association. American Pharmaceutical Association.