Mechanism and molecular basis for the sodium channel subtype specificity of µ‐conopeptide CnIIIC

BACKGROUND AND PURPOSE Voltage‐gated sodium channels (NaV channels) are key players in the generation and propagation of action potentials, and selective blockade of these channels is a promising strategy for clinically useful suppression of electrical activity. The conotoxin µ‐CnIIIC from the cone snail Conus consors exhibits myorelaxing activity in rodents through specific blockade of skeletal muscle (NaV1.4) NaV channels.

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