Use of the kinetic equilibrium between aminoacyl-tRNA formation and hydrolysis in inhibition assays of aminoacyl-tRNA synthetase.

[1]  A. Pope,et al.  A homogeneous method to measure aminoacyl-tRNA synthetase aminoacylation activity using scintillation proximity assay technology. , 2000, Analytical biochemistry.

[2]  A. K. Forrest,et al.  Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A. , 2000, Biochemistry.

[3]  Thomas D. Y. Chung,et al.  A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.

[4]  J Hill,et al.  Aminoacyl tRNA synthetases as targets for new anti‐infectives , 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  M. Horikoshi,et al.  Specific Interactions and Potential Functions of Human TAFII100* , 1997, The Journal of Biological Chemistry.

[6]  H. Jakubowski.  The synthetic/editing active site of an aminoacyl-tRNA synthetase: evidence for binding of thiols in the editing subsite. , 1996, Biochemistry.

[7]  D. Söll,et al.  Discrimination among tRNAs intermediate in glutamate and glutamine acceptor identity. , 1993, Biochemistry.

[8]  T. Steitz,et al.  Overproduction and purification of Escherichia coli tRNA(2Gln) and its use in crystallization of the glutaminyl-tRNA synthetase-tRNA(Gln) complex. , 1988, Journal of molecular biology.

[9]  R. Ogden,et al.  Changing the identity of a transfer RNA , 1986, Nature.

[10]  R. Buckingham,et al.  Protection against non-enzymatic deacylation of Met-tRNA Met m by the ribosome : an approach to the measurement of aminoacyl-tRNA : ribosome affinity constants. , 1980, Biochimie.

[11]  H. Jakubowski.  Incomplete aminoacylation of tRNALeu catalyzed in vitro by leucyl-tRNA synthetase from Escherichia coli B. , 1978, Biochimica et biophysica acta.

[12]  J. Ebel,et al.  Interpretation of tRNA-mischarging kinetics. , 1976, European journal of biochemistry.

[13]  J. Ebel,et al.  Interpretation of incomplete aminoacylation of yeast tRNA-Phe: evidence for a phenylalanyl-tRNA synthetase catalyzed transconformation of tRNA-Phe. , 1974, Biochimie.

[14]  J. Ebel,et al.  Interpretation of Incomplete Reactions in tRNA Aminoacylation , 1972 .