论文信息 - Synthesis, Structure, and Antitumor Activity of Novel Platinum(II) Complexes Involving Asymmetric Chiral Diamines as Carrier Ligands

Synthesis, Structure, and Antitumor Activity of Novel Platinum(II) Complexes Involving Asymmetric Chiral Diamines as Carrier Ligands

, Z = 8, R=0.093) exhibit that the platinum atoms achieve a typicalsquare planar arrangement with two nitrogen atoms in cis position and with the chiral center retained. The spec-troscopic data disclose that these platinum complexes are stable and their molecular structures are retained inaqueous solution. Among these platinum complexes, the asymmetric diamine-Pt(II) complexes with chlorideleaving group exhibit high in vivo activity comparable to cisplatin against leukemia L1210 cell line.IntroductionAccording to the conventional structure-activity relation-ships, for the platinum anticancer drugs

Y. Sohn | M. Jun | E. Lee

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