Magnetically uniform and tunable Janus particles

Magnetic particles serve as an important tool for a variety of biomedical applications but often lack uniformity in their magnetic responsiveness. For quantitative analysis studies, magnetic particles should ideally be monodisperse and possess uniform magnetic properties. Here we fabricate magnetically uniform Janus particles with tunable magnetic properties using a spin-coating and thermal evaporation method. The resulting 2 μm ferromagnetic particles exhibited a 4% magnetic response variability, and the 10 μm ferromagnetic particles exhibited a 1% size variability and an 8% magnetic response variability. Furthermore, by reducing the film thickness, the particle behavior was tuned from ferromagnetic to superparamagnetic.

[1]  R. Kopelman,et al.  High frequency asynchronous magnetic bead rotation for improved biosensors. , 2010, Applied physics letters.

[2]  M. Prins,et al.  Controlled torque on superparamagnetic beads for functional biosensors. , 2009, Biosensors & bioelectronics.

[3]  J. Dobson Magnetic nanoparticles for drug delivery , 2006 .

[4]  C. Ramchand,et al.  Application of magnetic techniques in the field of drug discovery and biomedicine , 2003, Biomagnetic research and technology.

[5]  Raoul Kopelman,et al.  Sudden breakdown in linear response of a rotationally driven magnetic microparticle and application to physical and chemical microsensing. , 2006, The journal of physical chemistry. B.

[6]  Roy Clarke,et al.  Compact sensor for measuring nonlinear rotational dynamics of driven magnetic microspheres with biomedical applications , 2009 .

[7]  Roy Clarke,et al.  Single bacterial cell detection with nonlinear rotational frequency shifts of driven magnetic microspheres , 2007 .

[8]  H. Takei and,et al.  Gradient Sensitive Microscopic Probes Prepared by Gold Evaporation and Chemisorption on Latex Spheres , 1997 .

[9]  M. Ozols,et al.  Dynamics of an active magnetic particle in a rotating magnetic field. , 2006, Physical review. E, Statistical, nonlinear, and soft matter physics.

[10]  X-ray magnetic circular dichroism characterization of GaN∕Ga1−xMnxN digital ferromagnetic heterostructure , 2007, cond-mat/0703477.

[11]  M. Burns,et al.  Monitoring the growth and drug susceptibility of individual bacteria using asynchronous magnetic bead rotation sensors. , 2011, Biosensors & bioelectronics.

[12]  Orlin D. Velev,et al.  Reconfigurable responsive structures assembled from magnetic Janus particles , 2009 .

[13]  Hugo Ferreira,et al.  Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited) , 2003 .

[14]  Raoul Kopelman,et al.  Label-acquired magnetorotation for biosensing: An asynchronous rotation assay. , 2011, Journal of magnetism and magnetic materials.

[15]  Johannes Boneberg,et al.  Magnetic multilayers on nanospheres , 2005, Nature materials.

[16]  A. Gast,et al.  Mechanics of semiflexible chains formed by poly(ethylene glycol)-linked paramagnetic particles. , 2003, Physical review. E, Statistical, nonlinear, and soft matter physics.

[17]  Dae Kun Hwang,et al.  Multifunctional superparamagnetic Janus particles. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[18]  Yi Liu,et al.  Handbook of Advanced Magnetic Materials , 2006 .

[19]  Gang Xiao,et al.  In situ detection of single micron-sized magnetic beads using magnetic tunnel junction sensors , 2005 .

[20]  R. Schmid,et al.  Preparation and biochemical and biomedical applications of new monosized polymer particles , 1993 .

[21]  Urs O. Häfeli,et al.  Optical method for measurement of magnetophoretic mobility of individual magnetic microspheres in defined magnetic field , 2005 .

[22]  V. Bliznyuk,et al.  Fabrication of Ni nanoparticles and their size-selective self-assembly into chains under external magnetic field , 2005 .

[23]  Haihui Ye,et al.  Carbon nanotubes loaded with magnetic particles. , 2005, Nano letters.

[24]  G. Frija,et al.  Superparamagnetic iron oxides as positive MR contrast agents: in vitro and in vivo evidence. , 1993, Magnetic resonance imaging.

[25]  R. Kopelman,et al.  Physiochemical microparticle sensors based on nonlinear magnetic oscillations , 2007 .

[26]  A. T. Giannitsis,et al.  Investigation of the complex susceptibility of magnetic beads containing maghemite nanoparticles , 2006 .

[27]  J. Lahann,et al.  Water-stable biphasic nanocolloids with potential use as anisotropic imaging probes. , 2007, Langmuir : the ACS journal of surfaces and colloids.