Three‐Component, One‐Pot Sequential Synthesis of Tetracyclic Pyrido[2′,1′:2,3]imidazo[5,1‐a]isoquinolinium Compounds as Potent Anticancer Agents

A new practical method for the synthesis of tetracyclic pyrido[2′,1′:2,3]imidazo[5,1-a]isoquinolinium compounds by a Yb(OTf)3/AgOTf-catalyzed (Tf = triflate) three-component domino reaction was developed. Significantly, the strategy presents a straightforward and efficient approach to constructing a series of compounds with potent cytotoxic activities.

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