GABAB Receptor Agonist R-Baclofen Reverses Social Deficits and Reduces Repetitive Behavior in Two Mouse Models of Autism

[1]  Takao K. Hensch,et al.  Sensory Integration in Mouse Insular Cortex Reflects GABA Circuit Maturation , 2014, Neuron.

[2]  M. Huntsman,et al.  Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala. , 2014, Journal of neurophysiology.

[3]  T. Bourgeron,et al.  Cntnap4/Caspr4 Differentially Contributes to GABAergic and Dopaminergic Synaptic Transmission , 2014, Nature.

[4]  K. Broadie,et al.  GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model , 2014, Neurobiology of Disease.

[5]  William A. Catterall,et al.  Enhancement of Inhibitory Neurotransmission by GABAA Receptors Having α2,3-Subunits Ameliorates Behavioral Deficits in a Mouse Model of Autism , 2014, Neuron.

[6]  S. Spence,et al.  A survey of seizures and current treatments in 15q duplication syndrome , 2014, Epilepsia.

[7]  J. Silverman,et al.  Chronic desipramine treatment rescues depression‐related, social and cognitive deficits in Engrailed‐2 knockout mice , 2014, Genes, brain, and behavior.

[8]  A. Clipperton-Allen,et al.  Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests. , 2014, Human molecular genetics.

[9]  D. Jaffe,et al.  Prefrontal cognitive deficits in mice with altered cerebral cortical GABAergic interneurons , 2014, Behavioural Brain Research.

[10]  Luke Bloy,et al.  GABA estimation in the brains of children on the autism spectrum: Measurement precision and regional cortical variation , 2014, NeuroImage.

[11]  J. Sharp,et al.  Clinical and genomic evaluation of 201 patients with Phelan–McDermid syndrome , 2014, Human Genetics.

[12]  Jeremy Veenstra-VanderWeele,et al.  Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice , 2013, Molecular Autism.

[13]  A. Joyner,et al.  Loss of GABAergic neurons in the hippocampus and cerebral cortex of Engrailed-2 null mutant mice: Implications for autism spectrum disorders , 2013, Experimental Neurology.

[14]  Mark J. Harris,et al.  Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2 , 2013, Behavioural Brain Research.

[15]  J. Crawley,et al.  Influence of stimulant-induced hyperactivity on social approach in the BTBR mouse model of autism , 2013, Neuropharmacology.

[16]  S. McTighe,et al.  The BTBR Mouse Model of Autism Spectrum Disorders Has Learning and Attentional Impairments and Alterations in Acetylcholine and Kynurenic Acid in Prefrontal Cortex , 2013, PloS one.

[17]  J. Crawley,et al.  AMPAKINE enhancement of social interaction in the BTBR mouse model of autism , 2013, Neuropharmacology.

[18]  J. Roder,et al.  Co-learning facilitates memory in mice: A new avenue in social neuroscience , 2013, Neuropharmacology.

[19]  G. Rouleau,et al.  Analysis of the effects of rare variants on splicing identifies alterations in GABAA receptor genes in autism spectrum disorder individuals , 2012, European Journal of Human Genetics.

[20]  L. Oberman mGluR antagonists and GABA agonists as novel pharmacological agents for the treatment of autism spectrum disorders , 2012, Expert opinion on investigational drugs.

[21]  T. Bourgeron,et al.  Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4 , 2012, Genes, brain, and behavior.

[22]  M. Sahin Targeted treatment trials for tuberous sclerosis and autism: no longer a dream , 2012, Current Opinion in Neurobiology.

[23]  M. Bear,et al.  Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABAB Receptors with Arbaclofen , 2012, Science Translational Medicine.

[24]  M. Bear,et al.  Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial , 2012, Science Translational Medicine.

[25]  S. Kagami,et al.  Evaluation of the GABAergic nervous system in autistic brain: 123I-iomazenil SPECT study , 2012, Brain and Development.

[26]  D. Blanchard,et al.  Absence of social conditioned place preference in BTBR T+tf/J mice: Relevance for social motivation testing in rodent models of autism , 2012, Behavioural Brain Research.

[27]  William A Catterall,et al.  Autistic behavior in Scn1a+/− mice and rescue by enhanced GABAergic transmission , 2012, Nature.

[28]  Jacqueline N. Crawley,et al.  Autistic-like behavior and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice , 2012, Nature.

[29]  R. Gur,et al.  GABAB-mediated rescue of altered excitatory–inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction , 2012, Translational Psychiatry.

[30]  James Y. Zhang,et al.  Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice , 2012, The Journal of Neuroscience.

[31]  Y. Park,et al.  GABAA and GABAB receptors have opposite effects on synaptic glutamate release on the nucleus tractus solitarii neurons , 2012, Neuroscience.

[32]  Jacqueline N. Crawley,et al.  Negative Allosteric Modulation of the mGluR5 Receptor Reduces Repetitive Behaviors and Rescues Social Deficits in Mouse Models of Autism , 2012, Science Translational Medicine.

[33]  Michael E. Ragozzino,et al.  Differences in BTBR T+ tf/J and C57BL/6J mice on probabilistic reversal learning and stereotyped behaviors , 2012, Behavioural Brain Research.

[34]  M. Huntsman,et al.  Impaired inhibitory control of cortical synchronization in fragile X syndrome. , 2011, Journal of neurophysiology.

[35]  G. Blatt,et al.  Alterations in GABAergic Biomarkers in the Autism Brain: Research Findings and Clinical Implications , 2011, Anatomical record.

[36]  Hongzhe Li,et al.  Deconstructing Sociability, An Autism‐Relevant Phenotype, in Mouse Models , 2011, Anatomical record.

[37]  D. Geschwind,et al.  Absence of CNTNAP2 Leads to Epilepsy, Neuronal Migration Abnormalities, and Core Autism-Related Deficits , 2011, Cell.

[38]  M. Fagiolini,et al.  Autism: A “Critical Period” Disorder? , 2011, Neural plasticity.

[39]  J. Silverman,et al.  Automated Three‐Chambered Social Approach Task for Mice , 2011, Current protocols in neuroscience.

[40]  Kenji Mori,et al.  Non-Invasive Evaluation of the GABAergic/Glutamatergic System in Autistic Patients Observed by MEGA-Editing Proton MR Spectroscopy Using a Clinical 3 Tesla Instrument , 2011, Journal of autism and developmental disorders.

[41]  Jacqueline N. Crawley,et al.  Sociability and motor functions in Shank1 mutant mice , 2011, Brain Research.

[42]  Valerie J. Bolivar,et al.  A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice , 2011, Behavioural Brain Research.

[43]  D C Blanchard,et al.  Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism , 2011, Genes, brain, and behavior.

[44]  Kathryn K. Chadman,et al.  Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism , 2011, Pharmacology Biochemistry and Behavior.

[45]  Valerie J. Bolivar,et al.  General and social anxiety in the BTBR T+ tf/J mouse strain , 2011, Behavioural Brain Research.

[46]  J. Hensler,et al.  Density and function of central serotonin (5‐HT) transporters, 5‐HT1A and 5‐HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior , 2011, Journal of neurochemistry.

[47]  Valerie J. Bolivar,et al.  Expression of social behaviors of C57BL/6J versus BTBR inbred mouse strains in the visible burrow system , 2010, Behavioural Brain Research.

[48]  Rodney C. Samaco,et al.  GABAergic dysfunction mediates autism-like stereotypies and Rett syndrome phenotypes , 2010, Nature.

[49]  P. Hagerman,et al.  Fragile X and autism: Intertwined at the molecular level leading to targeted treatments , 2010, Molecular autism.

[50]  W. Kaufmann,et al.  Defective GABAergic Neurotransmission and Pharmacological Rescue of Neuronal Hyperexcitability in the Amygdala in a Mouse Model of Fragile X Syndrome , 2010, The Journal of Neuroscience.

[51]  P. Levitt,et al.  Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes , 2010, Neuroscience.

[52]  C. Lord,et al.  Behavioural phenotyping assays for mouse models of autism , 2010, Nature Reviews Neuroscience.

[53]  J. Crawley,et al.  Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain , 2010, Behavioural Brain Research.

[54]  Jill L Silverman,et al.  Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP , 2010, Neuropsychopharmacology.

[55]  P. Stankiewicz,et al.  Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size , 2009, Journal of Medical Genetics.

[56]  T. Südhof,et al.  Common circuit defect of excitatory-inhibitory balance in mouse models of autism , 2009, Journal of Neurodevelopmental Disorders.

[57]  Thomas Bourgeron,et al.  A synaptic trek to autism , 2009, Current Opinion in Neurobiology.

[58]  F. Vaglini,et al.  Increased susceptibility to kainic acid–induced seizures in Engrailed-2 knockout mice , 2009, Neuroscience.

[59]  R. Paylor,et al.  Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety , 2009, Psychopharmacology.

[60]  G. Blatt,et al.  Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study , 2009, Autism research : official journal of the International Society for Autism Research.

[61]  S. Christian,et al.  Transmission disequilibrium testing of the chromosome 15q11‐q13 region in autism , 2008, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[62]  Jennette D. Driscoll,et al.  Chromosome 15q11–13 duplication syndrome brain reveals epigenetic alterations in gene expression not predicted from copy number , 2008, Journal of Medical Genetics.

[63]  Jacqueline N. Crawley,et al.  Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism , 2008, PloS one.

[64]  Shiaoching Gong,et al.  Minimal aberrant behavioral phenotypes of neuroligin‐3 R451C knockin mice , 2008, Autism research : official journal of the International Society for Autism Research.

[65]  Timothy M. DeLorey,et al.  Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: A potential model of autism spectrum disorder , 2008, Behavioural Brain Research.

[66]  H. McFarlane,et al.  Autism‐like behavioral phenotypes in BTBR T+tf/J mice , 2008, Genes, brain, and behavior.

[67]  Jacqueline N. Crawley,et al.  Social deficits in BTBR T + tf/J mice are unchanged by cross-fostering with C57BL/6J mothers , 2007, International Journal of Developmental Neuroscience.

[68]  Hewlet G McFarlane,et al.  Social Approach Behaviors are Similar on Conventional Versus Reverse Lighting Cycles, and in Replications Across Cohorts, in BTBR T+ tf/J, C57BL/6J, and Vasopressin Receptor 1B Mutant Mice , 2007, Frontiers in behavioral neuroscience.

[69]  Jacqueline N. Crawley,et al.  Social approach behaviors in oxytocin knockout mice: Comparison of two independent lines tested in different laboratory environments , 2007, Neuropeptides.

[70]  D. Geschwind,et al.  Autism spectrum disorders: developmental disconnection syndromes , 2007, Current Opinion in Neurobiology.

[71]  Jacqueline N. Crawley,et al.  Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains , 2007, Behavioural Brain Research.

[72]  Valerie J. Bolivar,et al.  Assessing autism-like behavior in mice: Variations in social interactions among inbred strains , 2007, Behavioural Brain Research.

[73]  S. Scherer,et al.  An inversion inv(4)(p12–p15.3) in autistic siblings implicates the 4p GABA receptor gene cluster , 2005, Journal of Medical Genetics.

[74]  E R Martin,et al.  Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. , 2005, American journal of human genetics.

[75]  J. Sutcliffe,et al.  A linkage disequilibrium map of the 1‐Mb 15q12 GABAA receptor subunit cluster and association to autism , 2004, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[76]  J. Piven,et al.  Automated apparatus for quantitation of social approach behaviors in mice , 2004, Genes, brain, and behavior.

[77]  M. Merzenich,et al.  Model of autism: increased ratio of excitation/inhibition in key neural systems , 2003, Genes, brain, and behavior.

[78]  S. Schulz,et al.  Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices , 2002, Biological Psychiatry.

[79]  J. Sutcliffe,et al.  Linkage disequilibrium at the Angelman syndrome gene UBE3A in autism families. , 2001, Genomics.

[80]  M. Cuccaro,et al.  Autism and maternally derived aberrations of chromosome 15q. , 1998, American journal of medical genetics.

[81]  N. Bowery,et al.  Characteristics of GABAB receptor binding sites on rat whole brain synaptic membranes , 1997 .

[82]  R. Paredes,et al.  Stereospecific actions of baclofen on sociosexual behavior, locomotor activity and motor execution , 1989, Psychopharmacology.

[83]  R. Weatherby,et al.  Bicuculline-insensitive GABA receptors: Studies on the binding of (−)-baclofen to rat cerebellar membranes , 1984, Neuroscience Letters.

[84]  Y. Huang Chronic desipramine treatment increases activity of noradrenergic postsynaptic cells. , 1979, Life sciences.

[85]  Mark R. McCoy,et al.  Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine. , 2015, Neurotoxicology and teratology.

[86]  M. Bear,et al.  STX209 (Arbaclofen) for Autism Spectrum Disorders: An 8-Week Open-Label Study , 2014, Journal of autism and developmental disorders.

[87]  R. Paylor,et al.  Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome , 2011, Psychopharmacology.

[88]  N. Bowery GABAB receptor pharmacology. , 1993, Annual review of pharmacology and toxicology.