Epinephrine inhibits PI3Kα via the Hippo kinases
暂无分享,去创建一个
Edward R. Kastenhuber | N. Vasan | M. Paddock | E. Kesicki | Kannan R. Karukurichi | Katarina M Liberatore | Shakti Ramsamooj | Mengmeng Zhu | Tomer M. Yaron | Thorsten Wiederhold | Emily M Huntsman | Jared L. Johnson | Robert E. Schwartz | Owen P McGuinness | Ting-Yu Lin | Tiffany Perrier | Louise Lantier | Neil Vasan | Seo-Kyoung Hwang | Yilun Ma | Guoan Zhang | Benjamin D. Hopkins | Baran A. Ersoy | Lewis C. Cantley | Marcus D. Goncalves
[1] Jared L. Johnson,et al. An atlas of substrate specificities for the human serine/threonine kinome , 2023, Nature.
[2] Jared L. Johnson,et al. Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication , 2022, Science Signaling.
[3] M. White,et al. TAZ inhibits glucocorticoid receptor and coordinates hepatic glucose homeostasis in normal physiological states , 2021, eLife.
[4] Xianming Deng,et al. Glycogen accumulation and phase separation drives liver tumor initiation , 2021, Cell.
[5] D. Duncker,et al. Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals? , 2021, Basic Research in Cardiology.
[6] G. Lewis,et al. Direct and indirect control of hepatic glucose production by insulin. , 2021, Cell metabolism.
[7] T. Harris,et al. Adipocyte lipolysis drives acute stress-induced insulin resistance , 2020, Scientific Reports.
[8] L. Cantley,et al. Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer , 2020, Nature Reviews Endocrinology.
[9] Matthew S. Tremblay,et al. Neratinib is an MST1 inhibitor and restores pancreatic β-cells in diabetes , 2019, Cell Death Discovery.
[10] Jared L. Johnson,et al. Double PIK3CA mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors , 2019, Science.
[11] Wenhao Zhang,et al. The Protein Phosphatase 1 Complex Is a Direct Target of AKT that Links Insulin Signaling to Hepatic Glycogen Deposition. , 2019, Cell reports.
[12] Suyong Choi,et al. The Specificity of EGF-Stimulated IQGAP1 Scaffold Towards the PI3K-Akt Pathway is Defined by the IQ3 motif , 2019, Scientific Reports.
[13] M. Malagón,et al. High-fat diet promotes adrenaline production by visceral adipocytes , 2019, European Journal of Nutrition.
[14] C. Dani,et al. Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue , 2019, Nature Communications.
[15] Chad J. Miller,et al. Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output , 2019, PLoS biology.
[16] G. Shulman,et al. Mechanisms of Insulin Action and Insulin Resistance. , 2018, Physiological reviews.
[17] J. Burke. Structural Basis for Regulation of Phosphoinositide Kinases and Their Involvement in Human Disease. , 2018, Molecular cell.
[18] Jamey D. Young,et al. Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice , 2017, The Journal of Biological Chemistry.
[19] J. Zalvide,et al. The MST3/STK24 kinase mediates impaired fasting blood glucose after a high-fat diet , 2017, Diabetologia.
[20] Lewis C. Cantley,et al. The PI3K Pathway in Human Disease , 2017, Cell.
[21] A. Toker,et al. AKT/PKB Signaling: Navigating the Network , 2017, Cell.
[22] N. Gray,et al. Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration , 2016, Science Translational Medicine.
[23] M. Czech,et al. Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases , 2016, Trends in Endocrinology & Metabolism.
[24] P. Romanienko,et al. A Vector with a Single Promoter for In Vitro Transcription and Mammalian Cell Expression of CRISPR gRNAs , 2016, PloS one.
[25] Yongjin Xu,et al. Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. , 2016, Bioorganic & medicinal chemistry letters.
[26] S. Steinbacher,et al. The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326). , 2016, Journal of medicinal chemistry.
[27] G. Halder,et al. MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway , 2015, Nature Communications.
[28] Jamey D. Young,et al. Mass spectrometry-based microassay of (2)H and (13)C plasma glucose labeling to quantify liver metabolic fluxes in vivo. , 2015, American journal of physiology. Endocrinology and metabolism.
[29] M. Czech,et al. Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues , 2015, Molecular and Cellular Biology.
[30] M. P. Dillon,et al. Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors. , 2015, ACS medicinal chemistry letters.
[31] Zoe Cournia,et al. Investigating the Structure and Dynamics of the PIK3CA Wild-Type and H1047R Oncogenic Mutant , 2014, PLoS Comput. Biol..
[32] J. Borén,et al. Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high‐fat diet , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[33] C. Buchanan,et al. Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase , 2013, Bioscience reports.
[34] Doriano Fabbro,et al. Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation. , 2013, Bioorganic & medicinal chemistry letters.
[35] Kun-Liang Guan,et al. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. , 2013, Genes & development.
[36] G. Stamp,et al. RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms , 2013, Cell.
[37] M. Schulze,et al. Association of Common Genetic Variants in the MAP4K4 Locus with Prediabetic Traits in Humans , 2012, PloS one.
[38] Xiang-Dong Fu,et al. Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling , 2012, Cell.
[39] P. Vogt,et al. Addition of N-terminal peptide sequences activates the oncogenic and signaling potentials of the catalytic subunit p110α of phosphoinositide-3-kinase , 2011, Cell cycle.
[40] Roger L. Williams,et al. Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases , 2011, Oncogene.
[41] Gregory Stephanopoulos,et al. Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry. , 2011, Analytical chemistry.
[42] J. Eriksson,et al. Effects of adrenaline on whole-body glucose metabolism and insulin-mediated regulation of glycogen synthase and PKB phosphorylation in human skeletal muscle. , 2011, Metabolism: clinical and experimental.
[43] Jeannie T. Lee,et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. , 2009, Cancer cell.
[44] K. Kinzler,et al. A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane , 2009, Proceedings of the National Academy of Sciences.
[45] K. Petersen,et al. Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans. , 2009, American journal of physiology. Endocrinology and metabolism.
[46] G. Rewcastle,et al. Functional differences between two classes of oncogenic mutation in the PIK3CA gene. , 2009, Biochemical and biophysical research communications.
[47] M. Mann,et al. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification , 2008, Nature Biotechnology.
[48] A. Pocai,et al. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2 , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[49] D. Wasserman,et al. Glucose Metabolism In Vivo in Four Commonly Used Inbred Mouse Strains , 2008, Diabetes.
[50] R. Copeland,et al. Effects of oncogenic p110α subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase , 2008 .
[51] Bert Vogelstein,et al. The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations , 2007, Science.
[52] G. Feldmann,et al. Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals , 2007, Cell.
[53] F. Dela,et al. Caffeine's impairment of insulin‐mediated glucose disposal cannot be solely attributed to adrenaline in humans , 2007, The Journal of physiology.
[54] Yuval Inbar,et al. Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit , 2007, Science.
[55] Marc-André Elsliger,et al. Rare cancer-specific mutations in PIK3CA show gain of function , 2007, Proceedings of the National Academy of Sciences.
[56] E. Kinoshita,et al. Phosphate-binding Tag, a New Tool to Visualize Phosphorylated Proteins*S , 2006, Molecular & Cellular Proteomics.
[57] Xiaoqing Tang,et al. An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[58] O. McGuinness,et al. Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. , 2006, Diabetes.
[59] M. Girvin,et al. Mechanism of Constitutive Phosphoinositide 3-Kinase Activation by Oncogenic Mutants of the p85 Regulatory Subunit* , 2005, Journal of Biological Chemistry.
[60] Craig R Malloy,et al. Impaired Tricarboxylic Acid Cycle Activity in Mouse Livers Lacking Cytosolic Phosphoenolpyruvate Carboxykinase* , 2004, Journal of Biological Chemistry.
[61] Lewis C Cantley,et al. A rapid method for determining protein kinase phosphorylation specificity , 2004, Nature Methods.
[62] E. Beutler,et al. The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[63] Shian Wu,et al. hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts , 2003, Cell.
[64] I. Hariharan,et al. The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis , 2003, Cell.
[65] T. Hunter,et al. The Protein Kinase Complement of the Human Genome , 2002, Science.
[66] L. Goodyear,et al. Contraction Regulation of Akt in Rat Skeletal Muscle* , 2002, The Journal of Biological Chemistry.
[67] Roger L. Williams,et al. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. , 2000, Molecular cell.
[68] Christian Ried,et al. Structural insights into phosphoinositide 3-kinase catalysis and signalling , 1999, Nature.
[69] A M Graybiel,et al. A family of cAMP-binding proteins that directly activate Rap1. , 1998, Science.
[70] A. Wittinghofer,et al. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP , 1998, Nature.
[71] K. Petersen,et al. Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans. , 1998, The Journal of clinical investigation.
[72] S. Harrison,et al. Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes , 1996, Nature Structural Biology.
[73] D. James,et al. Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. , 1985, The American journal of physiology.
[74] D. Wilmore,et al. Epinephrine acutely mediates skeletal muscle insulin resistance. , 1983, Surgery.
[75] R. DeFronzo,et al. Epinephrine-induced insulin resistance in man. , 1980, The Journal of clinical investigation.
[76] R. Rizza,et al. Adrenergic mechanisms for the effects of epinephrine on glucose production and clearance in man. , 1980, The Journal of clinical investigation.
[77] H. Berendsen,et al. The α-helix dipole and the properties of proteins , 1978, Nature.
[78] R. Steele,et al. Measurement of size and turnover rate of body glucose pool by the isotope dilution method. , 1956, The American journal of physiology.
[79] C. Cori,et al. THE INFLUENCE OF INSULIN AND EPINEPHRINE ON GLYCOGEN FORMATION IN THE LIVER , 1929 .