Unprecedented highly efficient capture of glycopeptides by Fe3O4@Mg-MOF-74 core-shell nanoparticles.

Magnetic Fe3O4 nanospheres coated with Mg-MOF-74 have been facilely prepared via epitaxial growth. Owing to the intrinsic hydrophilic pore surface and size-exclusive properties of Mg-MOF-74, the Fe3O4@Mg-MOF-74 core-shell nanoparticles show effective and selective enrichment of 441 N-glycosylation sites of 418 glycopeptides from 125 glycoproteins in 1 μL of human serum.

[1]  Pengyuan Yang,et al.  Development of Versatile Metal-Organic Framework Functionalized Magnetic Graphene Core-Shell Biocomposite for Highly Specific Recognition of Glycopeptides. , 2016, ACS applied materials & interfaces.

[2]  S. Tjin,et al.  The application of mesoporous silica nanoparticle family in cancer theranostics , 2016 .

[3]  Yu Bai,et al.  Post-synthetic modification of an amino-functionalized metal-organic framework for highly efficient enrichment of N-linked glycopeptides. , 2016, Nanoscale.

[4]  Ronghu Wu,et al.  Site-Specific Quantification of Surface N-Glycoproteins in Statin-Treated Liver Cells. , 2016, Analytical chemistry.

[5]  Jinping Wang,et al.  A pH-Driven and photoresponsive nanocarrier: Remotely-controlled by near-infrared light for stepwise antitumor treatment. , 2016, Biomaterials.

[6]  A. Piwowar,et al.  Changes in glycosylation of human blood plasma chitotriosidase in patients with type 2 diabetes , 2016, Glycoconjugate Journal.

[7]  Xiwen He,et al.  Click Synthesis of Hydrophilic Maltose-Functionalized Iron Oxide Magnetic Nanoparticles Based on Dopamine Anchors for Highly Selective Enrichment of Glycopeptides. , 2015, ACS applied materials & interfaces.

[8]  C. Deng,et al.  Facile synthesis of magnetic poly(styrene‐co‐4‐vinylbenzene‐boronic acid) microspheres for selective enrichment of glycopeptides , 2015, Proteomics.

[9]  P. Messersmith,et al.  Versatile Core-Shell Nanoparticle@Metal-Organic Framework Nanohybrids: Exploiting Mussel-Inspired Polydopamine for Tailored Structural Integration. , 2015, ACS nano.

[10]  H. Zou,et al.  Functionalizing with glycopeptide dendrimers significantly enhances the hydrophilicity of the magnetic nanoparticles. , 2015, Chemical communications.

[11]  Rongbing Huang,et al.  Targeted imaging and proteomic analysis of tumor-associated glycans in living animals. , 2014, Angewandte Chemie.

[12]  Jing Zhao,et al.  Glycan imaging in intact rat hearts and glycoproteomic analysis reveal the upregulation of sialylation during cardiac hypertrophy. , 2014, Journal of the American Chemical Society.

[13]  Guonan Chen,et al.  Click synthesis of glucose-functionalized hydrophilic magnetic mesoporous nanoparticles for highly selective enrichment of glycopeptides and glycans. , 2014, Journal of chromatography. A.

[14]  Huwei Liu,et al.  A facilely synthesized amino-functionalized metal-organic framework for highly specific and efficient enrichment of glycopeptides. , 2014, Chemical communications.

[15]  Qiang Xu,et al.  Metal-organic framework composites. , 2014, Chemical Society reviews.

[16]  Yayuan Liu,et al.  A Family of Metal‐Organic Frameworks Exhibiting Size‐Selective Catalysis with Encapsulated Noble‐Metal Nanoparticles , 2014, Advanced materials.

[17]  Haojie Lu,et al.  Hydrazide functionalized core-shell magnetic nanocomposites for highly specific enrichment of N-glycopeptides. , 2014, ACS applied materials & interfaces.

[18]  Haojie Lu,et al.  Highly efficient enrichment method for glycopeptide analyses: using specific and nonspecific nanoparticles synergistically. , 2014, Analytical chemistry.

[19]  Haojie Lu,et al.  Highly specific enrichment of N-linked glycopeptides based on hydrazide functionalized soluble nanopolymers. , 2014, Chemical communications.

[20]  W. Alley,et al.  Comparative profiling of N-glycans isolated from serum samples of ovarian cancer patients and analyzed by microchip electrophoresis. , 2013, Journal of proteome research.

[21]  H. Zou,et al.  Layer-by-layer assembly of multilayer polysaccharide coated magnetic nanoparticles for the selective enrichment of glycopeptides. , 2013, Chemical communications.

[22]  Michael O’Keeffe,et al.  The Chemistry and Applications of Metal-Organic Frameworks , 2013, Science.

[23]  S. Hattori,et al.  Site-specific quantitative analysis of overglycosylation of collagen in osteogenesis imperfecta using hydrazide chemistry and SILAC. , 2013, Journal of proteome research.

[24]  Rainer Bischoff,et al.  Glycopeptide enrichment and separation for protein glycosylation analysis. , 2012, Journal of separation science.

[25]  J. F. Stoddart,et al.  Large-Pore Apertures in a Series of Metal-Organic Frameworks , 2012, Science.

[26]  Hye-Young Cho,et al.  CO2 capture and conversion using Mg-MOF-74 prepared by a sonochemical method , 2012 .

[27]  Xiu‐Ping Yan,et al.  Metal-organic frameworks for efficient enrichment of peptides with simultaneous exclusion of proteins from complex biological samples. , 2011, Chemical communications.

[28]  Scott R. Kronewitter,et al.  Glycomics and disease markers. , 2009, Current opinion in chemical biology.

[29]  Pengyuan Yang,et al.  Facile synthesis of aminophenylboronic acid-functionalized magnetic nanoparticles for selective separation of glycopeptides and glycoproteins. , 2008, Chemical communications.

[30]  Richard Blom,et al.  Base‐Induced Formation of Two Magnesium Metal‐Organic Framework Compounds with a Bifunctional Tetratopic Ligand , 2008 .

[31]  Ruedi Aebersold,et al.  Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry , 2003, Nature Biotechnology.

[32]  I. Grundke‐Iqbal,et al.  Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease , 1996, Nature Medicine.

[33]  Raymond A. Dwek,et al.  Glycobiology: Toward Understanding the Function of Sugars. , 1996, Chemical reviews.