The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland

The G84E mutation in the HOXB13 gene has been associated with a high lifetime risk of prostate cancer in North America (about 20‐fold). The geographical and ethnic extent of this recurrent allele has not yet been determined.

[1]  Jianfeng Xu,et al.  A novel Germline mutation in HOXB13 is associated with prostate cancer risk in Chinese men , 2013, The Prostate.

[2]  J. Trachtenberg,et al.  Association between germline HOXB13 G84E mutation and risk of prostate cancer. , 2012, Journal of the National Cancer Institute.

[3]  Joan P. Breyer,et al.  Confirmation of the HOXB13 G84E Germline Mutation in Familial Prostate Cancer , 2012, Cancer Epidemiology, Biomarkers & Prevention.

[4]  D. Easton,et al.  Germline BRCA1 mutations increase prostate cancer risk , 2012, British Journal of Cancer.

[5]  J. Carpten,et al.  Germline mutations in HOXB13 and prostate-cancer risk. , 2012, The New England journal of medicine.

[6]  D. Easton,et al.  BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients , 2011, British Journal of Cancer.

[7]  Katherine M. Tucker,et al.  Targeted prostate cancer screening in men with mutations in BRCA1 and BRCA2 detects aggressive prostate cancer: preliminary analysis of the results of the IMPACT study , 2011, BJU international.

[8]  A. Borkowski,et al.  A large germline deletion in the Chek2 kinase gene is associated with an increased risk of prostate cancer , 2006, Journal of Medical Genetics.

[9]  J. Lubiński,et al.  Population Screening for Cancer Family Syndromes in the West Pomeranian Region of Poland , 2006, Hereditary Cancer in Clinical Practice.

[10]  J. Lubiński,et al.  CHEK2 is a multiorgan cancer susceptibility gene. , 2004, American journal of human genetics.

[11]  K. Offit,et al.  BRCA Mutations and Risk of Prostate Cancer in Ashkenazi Jews , 2004, Clinical Cancer Research.

[12]  A. Jakubowska,et al.  NBS1 Is a Prostate Cancer Susceptibility Gene , 2004, Cancer Research.

[13]  J. Schleutker,et al.  CHEK2 variants associate with hereditary prostate cancer , 2003, British Journal of Cancer.

[14]  David I. Smith,et al.  Mutations in CHEK2 associated with prostate cancer risk. , 2003, American journal of human genetics.

[15]  J. Carpten,et al.  Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk , 2002, Nature Genetics.

[16]  K. Klinger,et al.  Germline mutations in the ribonuclease L gene in families showing linkage with HPC1 , 2002, Nature Genetics.

[17]  J. Cerhan,et al.  Role of HPC2/ELAC2 in hereditary prostate cancer. , 2001, Cancer research.

[18]  J. Carpten,et al.  Evaluation of linkage and association of HPC2/ELAC2 in patients with familial or sporadic prostate cancer. , 2001, American journal of human genetics.

[19]  Siavash Ghaffari,et al.  A candidate prostate cancer susceptibility gene at chromosome 17p , 2001, Nature Genetics.

[20]  T. Rebbeck,et al.  Association of HPC2/ELAC2 genotypes and prostate cancer. , 2000, American journal of human genetics.

[21]  P. Hartge,et al.  The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. , 1997, The New England journal of medicine.

[22]  J. Eyfjörd,et al.  Study of a single BRCA2 mutation with high carrier frequency in a small population. , 1997, American journal of human genetics.

[23]  H. Grönberg,et al.  A population-based assessment of germline HOXB13 G84E mutation and prostate cancer risk. , 2014, European urology.

[24]  L. Tanoue Cancer Statistics, 2011: The Impact of Eliminating Socioeconomic and Racial Disparities on Premature Cancer Deaths , 2012 .

[25]  B. Ponder,et al.  Two percent of men with early-onset prostate cancer harbor germline mutations in the BRCA2 gene. , 2003, American journal of human genetics.

[26]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.