Ultrasonography and Pathological Evaluation of Cystic Endometrial Hyperplasia Pyometra Complex in Bitches and Queens with Related Ovarian Alterations

: Cystic endometrial hyperplasia - pyometra complex (CEHP) is a common female genital disorder encountered in bitches and queens, the etiopathogenesis of the condition is a complex one. This study aimed to investigate the role of ultrasonography and pathological examination as tools for diagnosis of the condition in addition to analyze the correlation between the development of the condition and related ovarian changes in bitch and queen. During the period from January 2010 to May 2013, 12 bitches and 36 queens of different breeds and ages (7 months up to 13 years) were examined clinically and by ultrasonography for CEHP then ovariohysterectomy was performed in positive cases. Tissue specimens from ovaries, fallopian tubes and uteri were collected for pathological examination. Obtained results indicated that higher incidence of CEHP was recorded in bitches and queens over six years old and the affection was more frequent during spring season. Griffon and Persian breeds were the most common affected breeds in bitches and queens respectively. Clinically, affected animals suffered from inappetence, depression, polydipsia, lethargy and abdominal distension with or without fever and vaginal discharge. Ultrasonographical examination revealed fluid filled uterus with variable wall thickness and proliferative changes. Gross examination revealed distension of uterine horns by capacious amount of pus with thickening and exaggerated nodularity. Microscopically, intense suppurative inflammatory reaction involving endometrial mucosa with marked cystic dilatation and hyperplastic proliferation of endometrial glands were observed. Moreover, variable ovarian alterations accompanied the development of CEHP. In conclusion, CEHP is a common genital affection in bitches and queens with seasonal and breed variation. Ultrasonography is a good diagnostic tool. Contraceptive pills administration and ovarian cysts are incriminated in the pathogenesis of such affection. for prostaglandin