Diffractive membrane imaging systems have been an important development trend for high-orbit satellite cameras owing to their advantages of large aperture, light weight, rapid manufacture, and low cost. However, caused by the cross-coupling effects of diffraction imaging, membrane properties, subaperture stitching, on-orbit disturbances, and other physical factors, lager-aperture space diffractive membrane imaging systems have specific and complex degradation characteristics: the modulation transfer function (MTF) and signal-to-noise ratio (SNR) have more prominent degradation and serious space-variant characteristics over fields of view, with obvious background radiation properties that seriously affect the application of imaging products. To address this problem, this study established a global information transmission model by characterizing the PSF and background radiation in a full field of view to represent the imaging law of an on-orbit system. Aiming at the inverse problem of the information transmission model, we also propose a novel image inversion restoration method for the special degradation characteristics. In particular, the effect of diffraction efficiency is introduced into the inversion restoration method to solve the background radiation problem. Moreover, we innovatively designed matrix regularization parameters to further improve the correction ability of spatial variation. When the diffraction efficiency was experimentally higher than 60% and the mean measured spatial variability was less than 0.2, the proposed method exhibited a satisfactory processing performance, and could improve multiobjective comprehensive processing, such as transfer function compensation, spatial variation correction, and background radiation removal.