Species differences in the disposition of propranolol prodrugs derived from hydrolase activity in intestinal mucosa.

[1]  T. Murakami,et al.  First-pass metabolism of ONO-5046 (N-[2-[4-(2,2-dimethylpropionyloxy) phenylsulfonylamino]benzoyl]aminoacetic acid), a novel elastase inhibitor, in rats. , 1997, Biological & pharmaceutical bulletin.

[2]  C. Sugimoto,et al.  Purification and characterization of a dog cytochrome P450 isozyme belonging to the CYP2D subfamily and development of its antipeptide antibody. , 1995, Drug metabolism and disposition: the biological fate of chemicals.

[3]  B. Yan,et al.  Regulation of two rat liver microsomal carboxylesterase isozymes: species differences, tissue distribution, and the effects of age, sex, and xenobiotic treatment of rats. , 1994, Archives of biochemistry and biophysics.

[4]  T. Imai,et al.  Stereoselective hydrolysis of O-isovaleryl propranolol and its influence on the clearance of propranolol after oral administration. , 1994, Journal of pharmaceutical sciences.

[5]  D. Petersen,et al.  Purification and characterization of two rat liver microsomal carboxylesterases (hydrolase A and B). , 1994, Archives of biochemistry and biophysics.

[6]  J. Fix,et al.  Use of everted intestinal rings for in vitro examination of oral absorption potential. , 1994, Journal of pharmaceutical sciences.

[7]  W. Boll,et al.  Messenger RNAs expressed in intestine of adult but not baby rabbits. Isolation of cognate cDNAs and characterization of a novel brush border protein with esterase and phospholipase activity. , 1993, The Journal of biological chemistry.

[8]  T. Imai,et al.  An In‐vitro and In‐vivo Correlative Approach to the Evaluation of Ester Prodrugs to Improve Oral Delivery of Propranolol , 1993, The Journal of pharmacy and pharmacology.

[9]  J. Gerber,et al.  Age and gender influence the stereoselective pharmacokinetics of propranolol. , 1992, The Journal of pharmacology and experimental therapeutics.

[10]  M Hosokawa,et al.  Characterization of molecular species of liver microsomal carboxylesterases of several animal species and humans. , 1990, Archives of biochemistry and biophysics.

[11]  C. Klaassen,et al.  Dosage-dependent absorption of cadmium in the rat intestine measured in situ. , 1989, Toxicology and applied pharmacology.

[12]  T. Terasaki,et al.  H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine. , 1987, The Journal of pharmacology and experimental therapeutics.

[13]  W. F. Hoffman,et al.  3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side chain ester derivatives of mevinolin. , 1986, Journal of medicinal chemistry.

[14]  K. Iwamoto,et al.  Dose‐dependent presystemic elimination of propranolol due to hepatic first‐pass metabolism in rats , 1985, The Journal of pharmacy and pharmacology.

[15]  C. A. Stone,et al.  A new class of angiotensin-converting enzyme inhibitors , 1980, Nature.

[16]  J. Hasegawa,et al.  Plasma propranolol levels in beagle dogs after administration of propranolol hemisuccinate ester. , 1978, Journal of pharmaceutical sciences.

[17]  B. Sjöberg,et al.  Bacampicillin: a New Orally Well-Absorbed Derivative of Ampicillin , 1975, Antimicrobial Agents and Chemotherapy.

[18]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[19]  A. Horita,et al.  Species differences for stereoselective hydrolysis of propranolol prodrugs in plasma and liver. , 1997, Chirality.

[20]  T. Imai,et al.  Stereoselective disposition of flurbiprofen from a mutual prodrug with a histamine H2-antagonist to reduce gastrointestinal lesions in the rat. , 1996, Chirality.

[21]  T. Walle,et al.  Stereoselective delivery and actions of beta receptor antagonists. , 1988, Biochemical pharmacology.

[22]  M. Tsuboi,et al.  Hydrolysis of ester-type drugs by the purified esterase from human intestinal mucosa. , 1979, Japanese journal of pharmacology.