Single-cell sequencing of the vermiform appendix during development identifies transcriptional relationships with appendicitis in preschool children

[1]  H. Cense,et al.  Enhanced Th17 responses in the appendix of children with complex compared to simple appendicitis are associated with microbial dysbiosis , 2024, Frontiers in immunology.

[2]  Longjie Huangfu,et al.  The IL-17 family in diseases: from bench to bedside , 2023, Signal transduction and targeted therapy.

[3]  Zifeng Li,et al.  Intestinal fibrosis in aganglionic segment of Hirschsprung's disease revealed by single‐cell RNA sequencing , 2023, Clinical and translational medicine.

[4]  S. Wong,et al.  Altered gut microbiome composition by appendectomy contributes to colorectal cancer , 2022, Oncogene.

[5]  S. Turjeman,et al.  Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress , 2022, bioRxiv.

[6]  N. Chiba,et al.  EGR1 plays an important role in BMP9‐mediated osteoblast differentiation by promoting SMAD1/5 phosphorylation , 2022, FEBS letters.

[7]  A. van Oudenaarden,et al.  BMP gradient along the intestinal villus axis controls zonated enterocyte and goblet cell states. , 2022, Cell reports.

[8]  K. Kovács,et al.  The Maternal–Fetal Gut Microbiota Axis: Physiological Changes, Dietary Influence, and Modulation Possibilities , 2022, Life.

[9]  Qiaojun He,et al.  New Insights of CCR7 Signaling in Dendritic Cell Migration and Inflammatory Diseases , 2022, Frontiers in Pharmacology.

[10]  M. Deli,et al.  The Active Role of Pericytes During Neuroinflammation in the Adult Brain , 2022, Cellular and Molecular Neurobiology.

[11]  F. Tang,et al.  Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals , 2022, Cell Research.

[12]  T. Okiji,et al.  Kinetics of LYVE-1-positive M2-like macrophages in developing and repairing dental pulp in vivo and their pro-angiogenic activity in vitro , 2022, Scientific Reports.

[13]  B. Helmink,et al.  LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth , 2021, The Journal of experimental medicine.

[14]  A. Theiss,et al.  RORγt protein modifications and IL-17-mediated inflammation. , 2021, Trends in immunology.

[15]  C. Selmi,et al.  The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function. , 2021, Autoimmunity reviews.

[16]  Min Yu,et al.  Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity , 2021, Journal of inflammation research.

[17]  J. Marioni,et al.  Cells of the human intestinal tract mapped across space and time , 2021, Nature.

[18]  Brian D. Gulbransen,et al.  Enteric glial biology, intercellular signalling and roles in gastrointestinal disease , 2021, Nature Reviews Gastroenterology & Hepatology.

[19]  G. Radenkovic,et al.  Interstitial Cells of Cajal and Neural Structures in the Human Fetal Appendix , 2021, Journal of neurogastroenterology and motility.

[20]  N. Ashley,et al.  Spatiotemporal analysis of human intestinal development at single-cell resolution , 2021, Cell.

[21]  Huanming Yang,et al.  Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma , 2020, Cell.

[22]  I. Glass,et al.  Mapping Development of the Human Intestinal Niche at Single-Cell Resolution. , 2020, Cell stem cell.

[23]  K. Itakura,et al.  Increased glucose metabolism in Arid5b−/− skeletal muscle is associated with the down-regulation of TBC1 domain family member 1 (TBC1D1) , 2020, Biological research.

[24]  H. Clevers,et al.  Cell fate specification and differentiation in the adult mammalian intestine , 2020, Nature reviews. Molecular cell biology.

[25]  S. Stritt,et al.  EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity , 2020, eLife.

[26]  Xin-Yuan Fu,et al.  Cholesterol 25-hydroxylase protects against experimental colitis in mice by modulating epithelial gut barrier function , 2020, Scientific Reports.

[27]  G. Kollias,et al.  The mesenchymal context in inflammation, immunity and cancer , 2020, Nature Immunology.

[28]  D. Peroni,et al.  Go With Your Gut: The Shaping of T-Cell Response by Gut Microbiota in Allergic Asthma , 2020, Frontiers in Immunology.

[29]  W. Watford,et al.  Placenta-specific 8 limits IFNγ production by CD4 T cells in vitro and promotes establishment of influenza-specific CD8 T cells in vivo , 2020, PloS one.

[30]  J. Dvorak,et al.  Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity , 2020, Nature Immunology.

[31]  B. Moran,et al.  IL‐17 in inflammatory skin diseases psoriasis and hidradenitis suppurativa , 2020, Clinical and experimental immunology.

[32]  J. McDonald,et al.  Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol , 2020, Nature Microbiology.

[33]  Deepali V. Sawant,et al.  Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer , 2020, Cell.

[34]  S. Turley,et al.  Lymph node stromal cells: cartographers of the immune system , 2020, Nature Immunology.

[35]  Liangming Liu,et al.  Research advances in pericyte function and their roles in diseases , 2020, Chinese journal of traumatology = Zhonghua chuang shang za zhi.

[36]  Guocheng Yuan,et al.  Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. , 2020, Cell stem cell.

[37]  S. Teichmann,et al.  Single-Cell Sequencing of Developing Human Gut Reveals Transcriptional Links to Childhood Crohn’s Disease , 2020, bioRxiv.

[38]  B. Honig,et al.  Sensing Actin Dynamics through Adherens Junctions. , 2020, Cell reports.

[39]  T. Crompton,et al.  The IFITM protein family in adaptive immunity , 2019, Immunology.

[40]  J. Cui,et al.  Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways , 2019, Cell.

[41]  J. Craig,et al.  Pericytes, inflammation, and diabetic retinopathy , 2019, Inflammopharmacology.

[42]  Xianwen Ren,et al.  Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma , 2019, Cell.

[43]  M. Boyce,et al.  The Not-so-Sterile Womb: Evidence That the Human Fetus Is Exposed to Bacteria Prior to Birth , 2019, Front. Microbiol..

[44]  Jay W. Shin,et al.  Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians , 2019, Proceedings of the National Academy of Sciences.

[45]  R. Morty,et al.  The Tcf21 lineage constitutes the lung lipofibroblast population. , 2019, American journal of physiology. Lung cellular and molecular physiology.

[46]  Dawn A. Delfín,et al.  The Extracellular Matrix Protein ABI3BP in Cardiovascular Health and Disease , 2019, Front. Cardiovasc. Med..

[47]  Nasullah Khalid Alham,et al.  Colonic epithelial cell diversity in health and inflammatory bowel disease , 2019, Nature.

[48]  J. Spencer,et al.  Human intestinal lymphoid tissue in time and space , 2018, Mucosal Immunology.

[49]  R. Cheluvappa.  Identification of New Potential Therapies for Colitis Amelioration Using an Appendicitis-Appendectomy Model. , 2018, Inflammatory bowel diseases.

[50]  Quin F. Wills,et al.  Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease , 2018, Cell.

[51]  E. Dubina,et al.  Perforation risk in pediatric appendicitis: assessment and management , 2018, Pediatric health, medicine and therapeutics.

[52]  R. Locksley,et al.  Innate Lymphoid Cells: 10 Years On , 2018, Cell.

[53]  S. Ryu,et al.  Mechanisms regulating intestinal barrier integrity and its pathological implications , 2018, Experimental & Molecular Medicine.

[54]  Jun Kit Wang,et al.  Hyaluronan Receptor LYVE‐1‐Expressing Macrophages Maintain Arterial Tone through Hyaluronan‐Mediated Regulation of Smooth Muscle Cell Collagen , 2018, Immunity.

[55]  F. Shibasaki,et al.  Eukaryotic translation initiation factor 3 (eIF3) subunit e is essential for embryonic development and cell proliferation , 2018, FEBS open bio.

[56]  Helge G. Roider,et al.  Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing , 2018, Nature Medicine.

[57]  D. Fried,et al.  Communication Between Enteric Neurons, Glia, and Nociceptors Underlies the Effects of Tachykinins on Neuroinflammation , 2018, Cellular and molecular gastroenterology and hepatology.

[58]  Mohamed Cherif El Amri,et al.  MARCKS and MARCKS-like proteins in development and regeneration , 2018, Journal of Biomedical Science.

[59]  T. Wester,et al.  Population‐based cohort study on the epidemiology of acute appendicitis in children in Sweden in 1987–2013 , 2018, BJS open.

[60]  A. Macpherson,et al.  The immunological functions of the Appendix: An example of redundancy? , 2018, Seminars in immunology.

[61]  S. Itzkovitz,et al.  Subepithelial telocytes are an important source of Wnts that supports intestinal crypts , 2018, Nature.

[62]  D. Menke,et al.  PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets. , 2017, Developmental biology.

[63]  U. Broeckel,et al.  PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development , 2017, Nature Communications.

[64]  Bin Zhang,et al.  IL-17B: A new area of study in the IL-17 family. , 2017, Molecular immunology.

[65]  T. Pastinen,et al.  Pitx1 directly modulates the core limb development program to implement hindlimb identity , 2017, Development.

[66]  S. Takeda,et al.  Direct reprogramming of fibroblasts into skeletal muscle progenitor cells by transcription factors enriched in undifferentiated subpopulation of satellite cells , 2017, Scientific Reports.

[67]  R. Andersson,et al.  Appendectomy and the Risk of Colectomy in Ulcerative Colitis: A National Cohort Study , 2017, The American Journal of Gastroenterology.

[68]  A. Cowin,et al.  The Importance of Pericytes in Healing: Wounds and other Pathologies , 2017, International journal of molecular sciences.

[69]  S. Gaffen,et al.  IL-17 Signaling: The Yin and the Yang. , 2017, Trends in immunology.

[70]  H. Almaramhy.  Acute appendicitis in young children less than 5 years: review article , 2017, Italian Journal of Pediatrics.

[71]  G. Berx,et al.  Zeb2 Regulates Cell Fate at the Exit from Epiblast State in Mouse Embryonic Stem Cells , 2016, Stem cells.

[72]  C. Buskens,et al.  The immunology of the vermiform appendix: a review of the literature , 2016, Clinical and experimental immunology.

[73]  Gunnar C. Hansson,et al.  Immunological aspects of intestinal mucus and mucins , 2016, Nature Reviews Immunology.

[74]  Charity C. Glass,et al.  Overview and diagnosis of acute appendicitis in children. , 2016, Seminars in pediatric surgery.

[75]  Charles H. Yoon,et al.  Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq , 2016, Science.

[76]  K. Ishii,et al.  Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα , 2016, European journal of immunology.

[77]  Scott N. Mueller,et al.  Tissue-resident memory T cells: local specialists in immune defence , 2015, Nature Reviews Immunology.

[78]  Aneel Bhangu,et al.  Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management , 2015, The Lancet.

[79]  S. Marchal,et al.  Mesenchymal–epithelial interactions during digestive tract development and epithelial stem cell regeneration , 2015, Cellular and Molecular Life Sciences.

[80]  M. Johansson,et al.  New developments in goblet cell mucus secretion and function , 2015, Mucosal Immunology.

[81]  P. de Santa Barbara,et al.  Enteric neural crest cells regulate vertebrate stomach patterning and differentiation , 2015, Development.

[82]  M. Affolter,et al.  Cdh5/VE-cadherin promotes endothelial cell interface elongation via cortical actin polymerization during angiogenic sprouting. , 2014, Cell reports.

[83]  M. Johansson,et al.  The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system , 2014, Immunological reviews.

[84]  E. Fishman,et al.  Anatomical variants and pathologies of the vermix , 2014, Emergency Radiology.

[85]  David Artis,et al.  Intestinal epithelial cells: regulators of barrier function and immune homeostasis , 2014, Nature Reviews Immunology.

[86]  Fan Zhang,et al.  PDGF-C: a new performer in the neurovascular interplay. , 2013, Trends in molecular medicine.

[87]  J. Mayr,et al.  Neurogenic Appendicopathy: Clinical, Macroscopic, and Histopathological Presentation in Pediatric Patients , 2013, European Journal of Pediatric Surgery.

[88]  W. Lamers,et al.  Possible roles of DLK1 in the Notch pathway during development and disease. , 2012, Biochimica et biophysica acta.

[89]  K. Park,et al.  Regulation of Wnt/β‐Catenin Signaling by CCAAT/Enhancer Binding Protein β During Adipogenesis , 2012, Obesity.

[90]  F. Matsumura,et al.  Fascin1 Promotes Cell Migration of Mature Dendritic Cells , 2011, The Journal of Immunology.

[91]  M. Mallick.  Appendicitis in pre-school children: a continuing clinical challenge. A retrospective study. , 2008, International journal of surgery.

[92]  A. Beggs,et al.  Acute appendicitis is characterized by a uniform and highly selective pattern of inflammatory gene expression , 2008, Mucosal Immunology.

[93]  M. Wong,et al.  BMP signaling in the intestine: cross-talk is key. , 2007, Gastroenterology.

[94]  W. Woodward,et al.  Disconnect Between Incidence of Nonperforated and Perforated Appendicitis: Implications for Pathophysiology and Management , 2007, Annals of surgery.

[95]  S. Narumiya,et al.  The Chemokine Receptor CCR7 Activates in Dendritic Cells Two Signaling Modules That Independently Regulate Chemotaxis and Migratory Speed1 , 2005, The Journal of Immunology.

[96]  A. Burns,et al.  Development of the enteric nervous system, smooth muscle and interstitial cells of Cajal in the human gastrointestinal tract , 2005, Cell and Tissue Research.

[97]  J. Laissue,et al.  Bacterial Translocation in the Normal Human Appendix Parallels the Development of the Local Immune System , 2004, Annals of the New York Academy of Sciences.

[98]  A. Gökçimen,et al.  Development of the vermiform appendix during the fetal period , 2004, Surgical and Radiologic Anatomy.

[99]  R. Pereira,et al.  CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation. , 2004, Endocrinology.

[100]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[101]  S. Rothrock,et al.  Acute appendicitis in children: emergency department diagnosis and management. , 2000, Annals of emergency medicine.

[102]  J. Cleveland,et al.  Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. , 2000, Immunity.

[103]  A. Prescher,et al.  Appendix and cecum. Embryology, anatomy, and surgical applications. , 2000, The Surgical clinics of North America.

[104]  M. Toborek,et al.  Endothelial cell functions.¶Relationship to atherogenesis , 1999, Basic Research in Cardiology.

[105]  M. Noda,et al.  A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta. , 1999, The Journal of biological chemistry.

[106]  P. Puri,et al.  Appendicitis in preschool children , 1995, Pediatric Surgery International.

[107]  R. Andersson,et al.  Indications for operation in suspected appendicitis and incidence of perforation , 1994, BMJ.

[108]  L. Kapila,et al.  Acute appendicitis in the preschool child. , 1991, Archives of disease in childhood.

[109]  J. Turner,et al.  The intestinal epithelial barrier: a therapeutic target? , 2017, Nature Reviews Gastroenterology &Hepatology.

[110]  S. S. St. Peter,et al.  Pediatric Appendicitis. , 2017, The Surgical clinics of North America.

[111]  K. Miyazono,et al.  Bone morphogenetic protein receptors and signal transduction. , 2010, Journal of biochemistry.

[112]  Gord Fishell,et al.  The role of notch in promoting glial and neural stem cell fates. , 2002, Annual review of neuroscience.