Childhood body mass index and wheezing disorders: a systematic review and meta‐analysis

It has been claimed that overweight/obesity, childhood asthma and wheezing disorders are associated, although the results of observational studies have remained inconsistent. We conducted a systematic review and meta‐analysis to investigate this.

[1]  Y. Lee,et al.  Gender-specific differences in associations of overweight and obesity with asthma and asthma-related symptoms in 30 056 children: result from 25 districts of Northeastern China , 2014, The Journal of asthma : official journal of the Association for the Care of Asthma.

[2]  M. Willeboordse,et al.  Sex Differences in the Relationship between Asthma and Overweight in Dutch Children: a Survey Study , 2013, PloS one.

[3]  Y. Manios,et al.  The obesity–asthma link in different ages and the role of Body Mass Index in its investigation: findings from the Genesis and Healthy Growth Studies , 2013, Allergy.

[4]  E. Porter,et al.  The Association Between BMI, Vigorous Physical Activity and Television Viewing and the Risk of Symptoms of Asthma, Rhinoconjunctivitis and Eczema in Children and Adolescents: ISAAC Phase Three , 2013, Pediatrics.

[5]  M. Moustaki,et al.  Associations of body fat percent and body mass index with childhood asthma by age and gender , 2013, Obesity.

[6]  M. Bracken,et al.  Childhood body mass index and subsequent physician-diagnosed asthma: a systematic review and meta-analysis of prospective cohort studies , 2013, BMC Pediatrics.

[7]  M. Barreto,et al.  The Prevalence of Wheezing and its Association with Body Mass Index and Abdominal Obesity in Children , 2013, The Journal of asthma : official journal of the Association for the Care of Asthma.

[8]  Y. Lee,et al.  Gender difference of childhood overweight and obesity in predicting the risk of incident asthma: a systematic review and meta‐analysis , 2013, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[9]  P. Hallal,et al.  Is Obesity a Risk Factor for Wheezing Among Adolescents? A Prospective Study in Southern Brazil , 2012, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[10]  T. Miyawaki,et al.  Association between obesity and asthma in Japanese preschool children , 2012, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[11]  Y. Lee,et al.  Obesity and the occurrence of bronchitis in adolescents , 2012, Obesity.

[12]  C. Koebnick,et al.  Higher Prevalence of Obesity Among Children With Asthma , 2012, Obesity.

[13]  M. Wickman,et al.  Early Childhood Overweight and Asthma and Allergic Sensitization at 8 Years of Age , 2012, Pediatrics.

[14]  G. Viegi,et al.  A cross-sectional study assessing the relationship between BMI, asthma, atopy, and eNO among schoolchildren. , 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[15]  W. Ho,et al.  Higher body mass index may induce asthma among adolescents with pre-asthmatic symptoms: a prospective cohort study , 2011, BMC public health.

[16]  S. Suglia,et al.  Asthma and obesity in three-year-old urban children: role of sex and home environment. , 2011, The Journal of pediatrics.

[17]  T. Yao,et al.  Associations of Age, Gender, and BMI with Prevalence of Allergic Diseases in Children: PATCH Study , 2011, The Journal of asthma : official journal of the Association for the Care of Asthma.

[18]  Á. Cruz,et al.  Overweight, asthma symptoms, atopy and pulmonary function in children of 4–12 years of age: findings from the SCAALA cohort in Salvador, Bahia, Brazil , 2011, Public Health Nutrition.

[19]  T. Miyawaki,et al.  Association of overweight with asthma symptoms in Japanese school children , 2011, Pediatrics international : official journal of the Japan Pediatric Society.

[20]  R. Gangnon,et al.  Early childhood weight status in relation to asthma development in high-risk children. , 2010, The Journal of allergy and clinical immunology.

[21]  F. Vázquez-Nava,et al.  Association between Obesity and Asthma in Preschool Mexican Children , 2010, TheScientificWorldJournal.

[22]  A. J. A. D. da Cunha,et al.  Association of Overweight with Asthma Prevalence in Adolescents in Rio de Janeiro, Brazil , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[23]  T. Wong,et al.  Respiratory health in overweight and obese Chinese children , 2009, Pediatric pulmonology.

[24]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement , 2009, BMJ : British Medical Journal.

[25]  D. Postma,et al.  Overweight and changes in weight status during childhood in relation to asthma symptoms at 8 years of age. , 2009, The Journal of allergy and clinical immunology.

[26]  A. Burton,et al.  Association Between Asthma Symptoms and Obesity in Preschool (4-5 year old) Children , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[27]  H. Tsai,et al.  The Association of BMI and Sedentary Time with Respiratory Symptoms and Asthma in 5th Grade Schoolchildren in Kaohsiung, Taiwan , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[28]  Karan P. Singh,et al.  Association between Obesity and Asthma in US Children and Adolescents , 2009, The Journal of asthma : official journal of the Association for the Care of Asthma.

[29]  G. Rücker,et al.  Undue reliance on I2 in assessing heterogeneity may mislead , 2008, BMC medical research methodology.

[30]  A. Goldsobel Relationship of Body Mass Index With Asthma Indicators in Head Start Children , 2008, Pediatrics.

[31]  J. Castro‐Rodriguez,et al.  Percent body fat, skinfold thickness or body mass index for defining obesity or overweight, as a risk factor for asthma in schoolchildren: which one to use in epidemiological studies? , 2008, Maternal & child nutrition.

[32]  T. Nakahata,et al.  Obesity and the prevalence of allergic diseases in schoolchildren , 2008, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[33]  A. Viera Odds ratios and risk ratios: what's the difference and why does it matter? , 2008, Southern medical journal.

[34]  Peter Lee,et al.  Facilitating meta‐analyses by deriving relative effect and precision estimates for alternative comparisons from a set of estimates presented by exposure level or disease category , 2008, Statistics in medicine.

[35]  R. Mellins,et al.  Asthma, body mass, gender, and Hispanic national origin among 517 preschool children in New York City , 2007, Allergy.

[36]  K. Flegal,et al.  Body mass index cut offs to define thinness in children and adolescents: international survey , 2007, BMJ : British Medical Journal.

[37]  M. Wickman,et al.  Birth anthropometric measures, body mass index and allergic diseases in a birth cohort study (BAMSE) , 2007, Archives of Disease in Childhood.

[38]  P. Romundstad,et al.  Female gender is associated with higher incidence and more stable respiratory symptoms during adolescence. , 2007, Respiratory medicine.

[39]  G. Giles,et al.  Childhood adiposity predicts adult-onset current asthma in females: a 25-yr prospective study , 2007, European Respiratory Journal.

[40]  Mariano Ruiz Espejo,et al.  WHO Child Growth Standards: Methods and Development , 2007 .

[41]  D. Ghosh,et al.  Associations of BMI, TV-Watching Time, and Physical Activity on Respiratory Symptoms and Asthma in 5th Grade Schoolchildren in Taipei, Taiwan , 2007, The Journal of asthma : official journal of the Association for the Care of Asthma.

[42]  M. Lipsett,et al.  An Association between Asthma and BMI in Adolescents: Results from the California Healthy Kids Survey , 2007, The Journal of asthma : official journal of the Association for the Care of Asthma.

[43]  R. Engels,et al.  Atopic diseases and related risk factors among Dutch adolescents. , 2006, European journal of public health.

[44]  M. Northridge,et al.  Childhood Asthma and Extreme Values of Body Mass Index: The Harlem Children’s Zone Asthma Initiative , 2006, Journal of Urban Health.

[45]  M. Shamssain The Association Between Overweight and Respiratory Symptoms in Schoolchildren , 2006 .

[46]  G. Rutherford,et al.  A meta-analysis of the effect of high weight on asthma , 2006, Archives of Disease in Childhood.

[47]  Dirceu Solé,et al.  Prevalência e gravidade da asma em adolescentes e sua relação com índice de massa corporal , 2005 .

[48]  C. Saha,et al.  Individual and neighborhood-level factors in predicting asthma. , 2005, Archives of pediatrics & adolescent medicine.

[49]  D. Solé,et al.  [Prevalence and severity of asthma among adolescents and their relationship with the body mass index]. , 2005, Jornal de pediatria.

[50]  J. Crane,et al.  Obesity and asthma in 11–12 year old New Zealand children in 1989 and 2000 , 2004, Thorax.

[51]  D. Fabian,et al.  The global burden of asthma: executive summary of the GINA Dissemination Committee Report , 2004, Allergy.

[52]  R. Peled,et al.  The Relationship Between Asthma and Obesity in Children: Is It Real or a Case of Over Diagnosis? , 2004, The Journal of asthma : official journal of the Association for the Care of Asthma.

[53]  D. Dockery,et al.  Body‐mass index as a predictor of incident asthma in a prospective cohort of children , 2003, Pediatric pulmonology.

[54]  K. Berhane,et al.  Obesity and the risk of newly diagnosed asthma in school-age children. , 2003, American journal of epidemiology.

[55]  M. Järvelin,et al.  Body build from birth to adulthood and risk of asthma. , 2002, European journal of public health.

[56]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[57]  H. Kraemer,et al.  Identification of population subgroups of children and adolescents with high asthma prevalence: findings from the Third National Health and Nutrition Examination Survey. , 2002, Archives of pediatrics & adolescent medicine.

[58]  S. Chinn,et al.  Can the increase in body mass index explain the rising trend in asthma in children? , 2001, Thorax.

[59]  Jonathan A C Sterne,et al.  Systematic reviews in health care: Investigating and dealing with publication and other biases in meta-analysis. , 2001, BMJ.

[60]  J. Castro‐Rodriguez,et al.  Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years. , 2001, American journal of respiratory and critical care medicine.

[61]  E. von Mutius,et al.  Is obesity a risk factor for childhood asthma? , 2001, Allergy.

[62]  T. Cole,et al.  Establishing a standard definition for child overweight and obesity worldwide: international survey , 2000, BMJ : British Medical Journal.

[63]  L. Epstein,et al.  The relationship between asthma and obesity in urban minority children and adolescents. , 1998, Archives of pediatrics & adolescent medicine.

[64]  J. Ioannidis,et al.  Summing up evidence: one answer is not always enough , 1998, The Lancet.

[65]  G. Smith,et al.  Bias in meta-analysis detected by a simple, graphical test , 1997, BMJ.

[66]  A Whitehead,et al.  A general parametric approach to the meta-analysis of randomized clinical trials. , 1991, Statistics in medicine.

[67]  N. Laird,et al.  Meta-analysis in clinical trials. , 1986, Controlled clinical trials.

[68]  THE WORLD HEALTH ORGANIZATION , 1954 .

[69]  P. Tugwell,et al.  The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses , 2014 .

[70]  Nicola Orsini,et al.  Meta-analysis for linear and nonlinear dose-response relations: examples, an evaluation of approximations, and software. , 2012, American journal of epidemiology.

[71]  S. London,et al.  Association of Childhood Obesity With Atopic and Nonatopic Asthma : Results From the National Health and Nutrition Examination Survey 1999 – 2006 , 2010 .

[72]  Abdullah Al Mamun,et al.  Increasing body mass index from age 5 to 14 years predicts asthma among adolescents: evidence from a birth cohort study , 2007, International Journal of Obesity.

[73]  D. Mannino,et al.  Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY) , 2006, International Journal of Obesity.