Phenome‐Wide Association Study of Rheumatoid Arthritis Subgroups Identifies Association Between Seronegative Disease and Fibromyalgia

The differences between seronegative and seropositive rheumatoid arthritis (RA) have not been widely reported. We performed electronic health record (EHR)–based phenome‐wide association studies (PheWAS) to identify disease associations in seropositive and seronegative RA.

[1]  Peter Szolovits,et al.  Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls. , 2013, Arthritis and rheumatism.

[2]  Hua Xu,et al.  Portability of an algorithm to identify rheumatoid arthritis in electronic health records , 2012, J. Am. Medical Informatics Assoc..

[3]  W. Müller,et al.  The frequency of transition of chronic low back pain to fibromyalgia. , 1995, Scandinavian journal of rheumatology.

[4]  F. Wolfe,et al.  Severe rheumatoid arthritis (RA), worse outcomes, comorbid illness, and sociodemographic disadvantage characterize ra patients with fibromyalgia. , 2004, The Journal of rheumatology.

[5]  Jeffrey R Curtis,et al.  2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease‐modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis , 2012, Arthritis care & research.

[6]  D. Solomon,et al.  Incidence and predictors of secondary fibromyalgia in an early arthritis cohort , 2012, Annals of the rheumatic diseases.

[7]  D. M. van der Heijde,et al.  Smoking as a risk factor for the radiological severity of rheumatoid arthritis: a study on six cohorts , 2014, Annals of the rheumatic diseases.

[8]  D. Roden,et al.  Development of a Large‐Scale De‐Identified DNA Biobank to Enable Personalized Medicine , 2008, Clinical pharmacology and therapeutics.

[9]  A. Silman,et al.  UvA-DARE (Digital Academic Repository) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative Aletaha, , 2010 .

[10]  Joshua C. Denny,et al.  R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment , 2014, Bioinform..

[11]  Inge Christoffer Olsen,et al.  Genetic risk scores and number of autoantibodies in patients with rheumatoid arthritis , 2013, Annals of the rheumatic diseases.

[12]  S. Gabriel,et al.  Predictors of infection in rheumatoid arthritis. , 2002, Arthritis and rheumatism.

[13]  F. Wolfe,et al.  The American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and Measurement of Symptom Severity , 2010, Arthritis care & research.

[14]  G. Kingsley,et al.  Fibromyalgic rheumatoid arthritis and disease assessment. , 2010, Rheumatology.

[15]  Patrice Degoulet,et al.  Phenome-Wide Association Studies on a Quantitative Trait: Application to TPMT Enzyme Activity and Thiopurine Therapy in Pharmacogenomics , 2013, PLoS Comput. Biol..

[16]  D. M. van der Heijde,et al.  High anti-cyclic citrullinated peptide levels and an algorithm of four variables predict radiographic progression in patients with rheumatoid arthritis: results from a 10-year longitudinal study , 2007, Annals of the rheumatic diseases.

[17]  Melissa A. Basford,et al.  Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data , 2013, Nature Biotechnology.

[18]  L. Klareskog,et al.  Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis , 2014, Nature Reviews Rheumatology.

[19]  S. Gabriel,et al.  Incidence and Mortality of Obstructive Lung Disease in Rheumatoid Arthritis: A Population‐Based Study , 2013, Arthritis care & research.

[20]  I. Kohane,et al.  Electronic medical records for discovery research in rheumatoid arthritis , 2010, Arthritis care & research.

[21]  D. Sexton.  Tofacitinib versus methotrexate in rheumatoid arthritis. , 2014, The New England journal of medicine.

[22]  M. Liang,et al.  The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. , 1988, Arthritis and rheumatism.

[23]  Melissa A. Basford,et al.  The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future , 2013, Genetics in Medicine.

[24]  Marylyn D. Ritchie,et al.  PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations , 2010, Bioinform..

[25]  S. Duvall,et al.  Risk of Hospitalized Bacterial Infections Associated With Biologic Treatment Among US Veterans With Rheumatoid Arthritis , 2014, Arthritis care & research.

[26]  Peter Nightingale,et al.  Predictive value of antibodies to cyclic citrullinated peptide in patients with very early inflammatory arthritis. , 2005, The Journal of rheumatology.

[27]  T. Therneau,et al.  Mortality trends in rheumatoid arthritis: the role of rheumatoid factor. , 2008, The Journal of rheumatology.

[28]  L. Arendt-Nielsen,et al.  Reproduction of overall spontaneous pain pattern by manual stimulation of active myofascial trigger points in fibromyalgia patients , 2011, Arthritis Research & Therapy.

[29]  G. Alarcón,et al.  Seronegative rheumatoid arthritis. , 1982 .

[30]  L. Alfredsson,et al.  A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis. , 2004, Arthritis and rheumatism.

[31]  J. Cerhan,et al.  Cigarette smoking and rheumatoid arthritis severity , 1997, Annals of the rheumatic diseases.

[32]  F. Tubach,et al.  High Levels of Anti-Cyclic Citrullinated Peptide Autoantibodies Are Associated with Co-occurrence of Pulmonary Diseases with Rheumatoid Arthritis , 2011, The Journal of Rheumatology.

[33]  S. Berney.  Comparison of Treatment Strategies in Early Rheumatoid Arthritis: A Randomized Trial , 2008 .

[34]  A. Young,et al.  Rheumatoid arthritis-related interstitial lung disease: associations, prognostic factors and physiological and radiological characteristics--a large multicentre UK study. , 2014, Rheumatology.

[35]  M. Uffmann,et al.  Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease. , 2006, Rheumatology.

[36]  A Calin,et al.  The hand radiograph as a diagnostic discriminant between seropositive and seronegative 'rheumatoid arthritis': a controlled study. , 1983, Annals of the rheumatic diseases.

[37]  R. Jacox,et al.  A study of the relation of seronegative and seropositive rheumatoid arthritis to each other and to necrotizing vasculitis. , 1969, The American journal of medicine.

[38]  G. Alarcón,et al.  Seronegative rheumatoid arthritis. A distinct immunogenetic disease? , 1982, Arthritis and rheumatism.

[39]  E. Keystone,et al.  Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: a randomized, placebo-controlled, 52-week trial. , 2004, Arthritis and rheumatism.

[40]  A. Silman,et al.  Association of the HLA–DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis , 2008, Arthritis and rheumatism.

[41]  H. Plischke,et al.  Association of Anti‐Cyclic Citrullinated Peptide Antibodies, Anti‐Citrullin Antibodies, and IgM and IgA Rheumatoid Factors with Serological Parameters of Disease Activity in Rheumatoid Arthritis , 2005, Annals of the New York Academy of Sciences.

[42]  Cynthia S Crowson,et al.  Incidence and mortality of interstitial lung disease in rheumatoid arthritis: a population-based study. , 2010, Arthritis and rheumatism.

[43]  Richard W. Martin,et al.  A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. , 2000, The New England journal of medicine.

[44]  Peter Szolovits,et al.  Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. , 2011, American journal of human genetics.

[45]  M. Prevoo,et al.  Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. , 1995, Arthritis and rheumatism.