Cholecystokinin receptors in GtoPdb v.2023.1 Cholecystokinin receptors in GtoPdb v.2023.1

Abstract Cholecystokinin receptors ( nomenclature as agreed by the nomenclature as agreed by the NC-IUPHARNC-IUPHAR Subcommittee on CCK receptors Subcommittee on CCK receptors [[9090]] ) are activated by the endogenous peptides cholecystokinin-8 (CCK-8), CCK-33, CCK-58 and gastrin (gastrin-17). There are only two distinct subtypes of CCK receptors, CCK 1 and CCK 2 receptors [64, 124], with some alternatively spliced forms most often identified in neoplastic cells. The CCK receptor subtypes are distinguished by their peptide selectivity, with the CCK 1 receptor requiring the carboxyl-terminal heptapeptide-amide that includes a sulfated tyrosine for high affinity and potency, while the CCK 2 receptor requires only the carboxyl-terminal tetrapeptide shared by each CCK and gastrin peptides. These receptors have characteristic and distinct distributions, with both present in both the central nervous system and peripheral tissues.