Hypercalcemia and Unilateral Ovarian Mass in a Young Adult: A Case Report of Small Cell Ovarian Carcinoma

Patient: Female, 31-year-old Final Diagnosis: Small cell ovarian cancer • hypercalcemic type Symptoms: Abdominal pain • bloating Medication: — Clinical Procedure: Surgery • adjuvant chemotherapy • adjuvant radiotherapy Specialty: Oncology Objective: Rare disease Background: Small cell ovarian carcinoma, hypercalcemic type is an uncommon malignant ovarian tumor entity with an unfavorable prognosis and a short overall survival rate. It mainly affects women of childbearing age. Case Report: We report a case in which a 31-year-old woman with small cell ovarian carcinoma, hypercalcemic type presented with unspecific symptoms. We emphasize the importance of treatment planning and address fertility-sparing surgical procedures, which remain a therapeutic dilemma. Conclusions: The occurrence of unspecific abdominal symptoms, unilateral tumor masses, and hypercalcemia may indicate the presence of malignant ovarian neoplasm in young adults. Histopathological examination of the mass should be performed by an experienced gynecological pathologist. A misdiagnosis can lead to inadequate surgical and adjuvant treatment. Adjuvant multi-agent chemotherapy and high-dose chemotherapy with autologous stem cell rescue may prolong the progression-free interval and overall survival.

[1]  D. Levine,et al.  Small cell cancers of the female genital tract: Molecular and clinical aspects. , 2018, Gynecologic oncology.

[2]  W. Foulkes,et al.  Rare non-epithelial ovarian neoplasms: Pathology, genetics and treatment. , 2016, Gynecologic oncology.

[3]  J. Trent,et al.  The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type. , 2016, Gynecologic oncology.

[4]  P. Ramirez,et al.  Radiotherapy for recurrent small cell carcinoma of the ovary: A case report and review of the literature , 2014, Gynecologic oncology reports.

[5]  J. Pressey,et al.  Successful Treatment of Preadolescents With Small Cell Carcinoma of the Ovary Hypercalcemic Type , 2013, Journal of pediatric hematology/oncology.

[6]  S. Darb-Esfahani,et al.  Clinical experience of young patients with small cell ovarian carcinoma of the hypercalcemic type (OSCCHT). , 2012, European journal of obstetrics, gynecology, and reproductive biology.

[7]  K. Münstedt,et al.  Small cell carcinoma of the ovary of the hypercalcaemic type: an analysis of clinical and prognostic aspects of a rare disease on the basis of cases published in the literature , 2011, Archives of Gynecology and Obstetrics.

[8]  D. Valteau‐Couanet,et al.  Successful treatment for advanced small cell carcinoma of the ovary , 2008, Pediatric blood & cancer.

[9]  F. Mayer,et al.  Results of a prospective dose-intensive regimen in 27 patients with small cell carcinoma of the ovary of the hypercalcemic type. , 2007, Annals of oncology : official journal of the European Society for Medical Oncology.

[10]  G. Fleischhack,et al.  Ovarian small cell carcinoma of the hypercalcemic type in children and adolescents , 2006, Cancer.

[11]  J. Ledermann,et al.  Small cell of the ovary, hypercalcemic type -- analysis of combined experience and recommendation for management. A GCIG study. , 2006, Gynecologic oncology.

[12]  R. Boothby,et al.  Small cell carcinoma of the ovary with hypercalcemia causes severe pancreatitis and altered mental status. , 2004, Gynecologic oncology.

[13]  A. Williams,et al.  Small cell carcinoma of the ovary: a report of three cases and review of the literature , 2004, Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology.

[14]  S. Florell,et al.  Ovarian small cell carcinoma of the hypercalcemic type in a 14 month old: the youngest reported case. , 1999, Medical and pediatric oncology.

[15]  E. Oliva,et al.  Small Cell Carcinoma of the Ovary, Hypercalcemic Type: A Clinicopathological Analysis of 150 Cases , 1994, The American journal of surgical pathology.

[16]  M. Munsell,et al.  Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT): A review of 47 cases. , 2016, Gynecologic oncology.

[17]  R. Scully,et al.  Small cell carcinoma of the ovary with hypercalcemia: A report of eleven cases , 1982, Cancer.