Results of conservative management of epithelial malignant and borderline ovarian tumours.

Conservative management of at least part of both the ovary and uterus can be proposed in patients with borderline ovarian tumour, in order to preserve fertility potential. This conservative management could be carried out even in patients with borderline ovarian tumour associated with non-invasive peritoneal implants (if complete resection of peritoneal disease has been performed). When facing persistent infertility after this conservative surgery, ovarian induction or an in-vitro procedure could be proposed in patients with an early-stage disease, though the number of attempts must be limited. Removal of the preserved ovary after completion of pregnancy(ies) is unnecessary if patients agree to careful follow-up. In patients with epithelial ovarian cancer, conservative management could safely be performed in young patients who wish to preserve fertility function and who fulfil the following criteria: unilateral tumour (stage IA), grade 1 (and 2?), adequate staging surgery and careful follow-up. Removal of the preserved ovary should be carried out after completion of pregnancy(ies) in order to reduce the risk of ovarian tumour recurrence.

[1]  J. Prat,et al.  Serous Borderline Tumors of the Ovary: A Long-Term Follow-Up Study of 137 Cases, Including 18 With a Micropapillary Pattern and 20 With Microinvasion , 2002, The American journal of surgical pathology.

[2]  R. Kurman,et al.  Treatment of micropapillary serous ovarian carcinoma (the aggressive variant of serous borderline tumors) , 2002, Cancer.

[3]  E. Trimble,et al.  Long-term survival and patterns of care in women with ovarian tumors of low malignant potential. , 2002, Gynecologic oncology.

[4]  D. Atallah,et al.  Fertility results after conservative treatment of advanced stage serous borderline tumour of the ovary , 2002, BJOG : an international journal of obstetrics and gynaecology.

[5]  A. Bagnoli,et al.  Fertility and tumor recurrence rate after conservative laparoscopic management of young women with early-stage borderline ovarian tumors. , 2001, Fertility and sterility.

[6]  C. Haie-meder,et al.  Results of conservative treatment in epithelial ovarian carcinoma , 2001, Cancer.

[7]  B. Davidson,et al.  Infertility treatment after conservative management of borderline ovarian tumors , 2001, Cancer.

[8]  C. Mangioni,et al.  Behavior of borderline tumors with particular interest to persistence, recurrence, and progression to invasive carcinoma: a prospective study. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[9]  Joos Vandewalle,et al.  Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma , 2001, The Lancet.

[10]  T. Yamada,et al.  Lymph node metastasis in stage I epithelial ovarian cancer. , 2000, Gynecologic oncology.

[11]  M. Canis,et al.  Successful transfer of frozen-thawed embryos obtained immediately before radical surgery for stage IIIa serous borderline ovarian tumour: case report. , 2000, Human reproduction.

[12]  M. Follen,et al.  Outcome and reproductive function after conservative surgery for borderline ovarian tumors. , 2000 .

[13]  J. Wharton,et al.  Outcome and reproductive function after chemotherapy for ovarian dysgerminoma. , 1999, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  C. Benadiva,et al.  In vitro fertilization following conservative management of stage 3 serous borderline tumor of the ovary. , 1999, Gynecologic oncology.

[15]  J. Magrina,et al.  Contralateral pelvic and aortic lymph node metastasis in clinical stage I epithelial ovarian cancer. , 1999, Gynecologic oncology.

[16]  Yuchiao Chang,et al.  Epithelial ovarian carcinoma in the reproductive age group , 1999, Cancer.

[17]  P. Disaia,et al.  Long-term consequences following conservative management of epithelial ovarian cancer in an infertile patient. , 1999, Gynecologic oncology.

[18]  R. Scully,et al.  Ovarian serous borderline tumors with micropapillary and cribriform patterns: a study of 40 cases and comparison with 44 cases without these patterns. , 1999, The American journal of surgical pathology.

[19]  M. Morgan,et al.  Occult bilateral involvement in stage I epithelial ovarian cancer. , 1999, Gynecologic oncology.

[20]  E. Darai,et al.  Management and outcome of borderline ovarian tumors incidentally discovered at or after laparoscopy , 1998, Acta obstetricia et gynecologica Scandinavica.

[21]  L. Levy,et al.  Ovarian serous borderline tumors with invasive peritoneal implants , 1998, Cancer.

[22]  Baiocchi,et al.  Early ovarian cancer: Is there a role for systematic pelvic and para- aortic lymphadenectomy? , 1998 .

[23]  M. Koshiyama,et al.  Management of Malignant Ovarian Tumors in Young Women , 1998, Gynecologic and Obstetric Investigation.

[24]  D. Paladini,et al.  Conservative surgery in high-risk epithelial ovarian carcinoma , 1997 .

[25]  V. Torri,et al.  Conservative surgery for Stage I ovarian carcinoma in women of childbearing age , 1997, British journal of obstetrics and gynaecology.

[26]  T. Ehlen,et al.  Successful term pregnancy following conservative debulking surgery for a stage IIIA serous low-malignant-potential tumor of the ovary: a case report. , 1997, Gynecologic oncology.

[27]  E. Salazar-Martínez,et al.  Conservative surgery for ovarian cancer and effect on fertility , 1997, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[28]  A. Tamakoshi,et al.  Clinical behavior of borderline ovarian tumors: A study of 150 cases , 1997, Journal of surgical oncology.

[29]  R. Kurman,et al.  Subclassification of serous borderline tumors of the ovary into benign and malignant types. A clinicopathologic study of 65 advanced stage cases. , 1996, The American journal of surgical pathology.

[30]  C. B‐Lynch,et al.  Borderline ovarian cancer, bilateral surgical castration, chemotherapy and a normal delivery after ovum donation and in vitro fertilisation‐embryo transfer , 1996, British journal of obstetrics and gynaecology.

[31]  Y. Taketani,et al.  Assessment of metastases to aortic and pelvic lymph nodes in epithelial ovarian carcinoma: A proposal for essential sites for lymph node biopsy , 1996, Cancer.

[32]  W. R. Hart,et al.  Ovarian papillary serous tumors of low malignant potential (Serous borderline tumors): A long term follow‐up study, including patients with microinvasion, lymph node metastasis, and transformation to invasive serous carcinoma , 1996, Cancer.

[33]  E. Yordan,et al.  Preliminary analysis of the behavior of stage I ovarian serous tumors of low malignant potential: a Gynecologic Oncology Group study. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[34]  D. Sturdee,et al.  Conservative management of ovarian cancer in a 15‐year‐old patient , 1995, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[35]  V. Torri,et al.  Controversial issues in the management of early epithelial ovarian cancer: conservative surgery and role of adjuvant therapy. , 1994, Gynecologic oncology.

[36]  P. Zourlas,et al.  Five years' follow-up in two patients with borderline tumours of the ovary hyperstimulated by gonadotrophin therapy for in-vitro fertilization. , 1994, Human reproduction.

[37]  H. Stettner,et al.  Lymphadenectomy in stage I ovarian cancer , 1994, American journal of obstetrics and gynecology.

[38]  G. Scambia,et al.  Anatomical and pathological study of retroperitoneal nodes in epithelial ovarian cancer. , 1993, Gynecologic oncology.

[39]  J. Woodruff,et al.  Long-term follow-up of serous ovarian tumors of low malignant potential. , 1992, Gynecologic oncology.

[40]  R. Izumi,et al.  [Ovarian epithelial tumors of borderline malignancy]. , 1992, Rinsho byori. The Japanese journal of clinical pathology.

[41]  W. Creasman,et al.  Epithelial Ovarian Tumors of Low Malignant Potential , 1991, Obstetrics and gynecology.

[42]  B. Piura,et al.  Epithelial ovarian tumors of borderline malignancy: a study of 50 cases , 1991, International Journal of Gynecologic Cancer.

[43]  C. Cohen,et al.  The concept of uterine preservation with ovarian malignancies. , 1991, Obstetrics and gynecology.

[44]  R. Berkowitz,et al.  Epithelial ovarian tumors of borderline malignancy. , 1990, Gynecologic oncology.

[45]  P. Disaia,et al.  Conservative management of the patient with early gynecologic cancer , 1989, CA: a cancer journal for clinicians.

[46]  M. Weinstock,et al.  Peritoneal implants of ovarian serous borderline tumors: Histologic features and prognosis , 1988, Cancer.

[47]  Scully Re,et al.  Ovarian cystectomy for serous borderline tumors: a follow-up study of 35 cases. , 1988 .

[48]  Y. Tomoda,et al.  Preservation of ovarian function and reproductive ability in patients with malignant ovarian tumors. , 1988, Gynecologic oncology.

[49]  D. Bostwick,et al.  Ovarian epithelial tumors of borderline malignancy: A clinical and pathologic study of 109 cases , 1986, Cancer.

[50]  D. Bostwick,et al.  Conservative Treatment of Borderline Ovarian Tumors , 1985, Obstetrics and gynecology.

[51]  F. Langley,et al.  The outlook for women with borderline epithelia tumours of the ovary. , 1985, British journal of obstetrics and gynaecology.

[52]  Schwartz Pe Combination chemotherapy in the management of ovarian germ cell malignancies. , 1984 .

[53]  W. Creasman,et al.  Germ Cell Malignancies of the Ovary , 1979, Obstetrics and gynecology.

[54]  T. E. Morgan,et al.  Proliferative serous tumors of the ovary: Histologic features and prognosis , 1978, The American journal of surgical pathology.

[55]  W. R. Hart,et al.  Borderline and malignant mucinous tumors of the ovary. Histologic criteria and clinical behavior , 1973, Cancer.

[56]  Woodruff Jd,et al.  The biologic behavior of low-grade papillary serous carcinoma of the ovary. , 1972 .

[57]  E. W. Munnell Is conservative therapy ever justified in stage I (IA) cancer of the ovary? , 1969, American journal of obstetrics and gynecology.

[58]  B. Karlan,et al.  Pattern of lymph node metastases in clinically unilateral stage I invasive epithelial ovarian carcinomas. , 2001, Gynecologic oncology.

[59]  M. Marchetti,et al.  Malignant ovarian tumors: conservative surgery and quality of life in young patients. , 1998, European journal of gynaecological oncology.

[60]  B. Davidson,et al.  Borderline tumors of the ovary , 1998, Cancer.

[61]  A. Fyles,et al.  Borderline epithelial ovarian tumors: a review of 81 cases with an assessment of the impact of treatment. , 1992, International journal of radiation oncology, biology, physics.

[62]  J. Baak,et al.  Borderline malignancy of the ovary and controlled hyperstimulation, a report of 2 cases. , 1992, European journal of cancer.