Plasma amyloid beta 40/42, phosphorylated tau 181, and neurofilament light are associated with cognitive impairment and neuropathological changes among World Trade Center responders: A prospective cohort study of exposures and cognitive aging at midlife

World Trade Center (WTC) responders are experiencing a high risk of mild cognitive impairment (MCI) and dementia, though the etiology remains inadequately characterized. This study investigated whether WTC exposures and chronic post‐traumatic stress disorder (PTSD) were correlated with plasma biomarkers characteristic of Alzheimer's disease (AD) neuropathology.

[1]  R. Kotov,et al.  World Trade Center Site Exposure Duration Is Associated with Hippocampal and Cerebral White Matter Neuroinflammation , 2022, Molecular neurobiology.

[2]  R. Kotov,et al.  Cortical complexity in world trade center responders with chronic posttraumatic stress disorder , 2021, Translational Psychiatry.

[3]  A. Spiro,et al.  Cognitive impairment and World Trade Centre-related exposures , 2021, Nature Reviews Neurology.

[4]  R. Zeig-Owens,et al.  Twenty-Year Reflection on the Impact of World Trade Center Exposure on Pulmonary Outcomes in Fire Department of the City of New York (FDNY) Rescue and Recovery Workers , 2021, Lung.

[5]  Lauren L. Richmond,et al.  A deep learning approach for monitoring parietal-dominant Alzheimer’s disease in World Trade Center responders at midlife , 2021, Brain communications.

[6]  O. Hansson,et al.  Plasma biomarkers of Alzheimer’s disease improve prediction of cognitive decline in cognitively unimpaired elderly populations , 2021, Nature Communications.

[7]  P. Svenningsson,et al.  A multicentre validation study of the diagnostic value of plasma neurofilament light , 2021, Nature Communications.

[8]  M. Sano,et al.  White Matter Connectivity in Incident Mild Cognitive Impairment: A Diffusion Spectrum Imaging Study of World Trade Center Responders at Midlife , 2021, Journal of Alzheimer's disease : JAD.

[9]  K. Blennow,et al.  Prediction of future Alzheimer’s disease dementia using plasma phospho-tau combined with other accessible measures , 2021, Nature Medicine.

[10]  M. Bondi,et al.  Higher cerebrospinal fluid tau is associated with history of traumatic brain injury and reduced processing speed in Vietnam‐era veterans: A Department of Defense Alzheimer's Disease Neuroimaging Initiative (DOD‐ADNI) study , 2021, Alzheimer's & dementia.

[11]  Cheuk Y. Tang,et al.  Selective hippocampal subfield volume reductions in World Trade Center responders with cognitive impairment , 2021, Alzheimer's & dementia.

[12]  W. M. van der Flier,et al.  Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline , 2020, Alzheimer's research & therapy.

[13]  Cheuk Y. Tang,et al.  Reduced cortical thickness in World Trade Center responders with cognitive impairment , 2020, Alzheimer's & Dementia.

[14]  K. Blennow,et al.  Plasma phosphorylated tau181 and neurodegeneration in Alzheimer’s disease , 2020, Annals of clinical and translational neurology.

[15]  R. Kotov,et al.  Chronic Posttraumatic Stress Disorder and Comorbid Cognitive and Physical Impairments in World Trade Center Responders , 2020, Journal of traumatic stress.

[16]  B. Luft,et al.  Acute versus Chronic Exposures to Inhaled Particulate Matter and Neurocognitive Dysfunction: Pathways to Alzheimer's Disease or a Related Dementia. , 2020, Journal of Alzheimer's disease : JAD.

[17]  K. Blennow,et al.  Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts , 2020, The Lancet Neurology.

[18]  M. Sano,et al.  Pathway Analysis for Plasma β-Amyloid, Tau and Neurofilament Light (ATN) in World Trade Center Responders at Midlife , 2020, Neurology and Therapy.

[19]  Albert Hofman,et al.  Plasma tau, neurofilament light chain and amyloid-β levels and risk of dementia; a population-based cohort study , 2020, Brain : a journal of neurology.

[20]  D. Balota,et al.  Neurofilament Light Predicts Decline in Attention but Not Episodic Memory in Preclinical Alzheimer's Disease. , 2020, Journal of Alzheimer's disease : JAD.

[21]  K. Blennow,et al.  Plasma P-tau181 in Alzheimer’s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer’s dementia , 2020, Nature Medicine.

[22]  Cheuk Y. Tang,et al.  Reduced cortical thickness in World Trade Center responders with cognitive impairment , 2020, Alzheimer's & dementia.

[23]  T. Morgan,et al.  Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts. , 2019, Free radical biology & medicine.

[24]  J. Molinuevo,et al.  Latest advances in cerebrospinal fluid and blood biomarkers of Alzheimer’s disease , 2019, Therapeutic advances in neurological disorders.

[25]  James G. Bollinger,et al.  High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis , 2019, Neurology.

[26]  M. Sano,et al.  Incidence of mild cognitive impairment in World Trade Center responders: Long-term consequences of re-experiencing the events on 9/11/2001 , 2019, Alzheimer's & dementia.

[27]  K. Blennow,et al.  Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease. , 2019, JAMA neurology.

[28]  P. Tariot,et al.  Present Algorithms and Future Treatments for Alzheimer’s Disease , 2019, Journal of Alzheimer's disease : JAD.

[29]  Nick C Fox,et al.  Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease , 2019, Nature Medicine.

[30]  M. Franklin,et al.  Comparing performance between log-binomial and robust Poisson regression models for estimating risk ratios under model misspecification , 2018, BMC Medical Research Methodology.

[31]  C. Jack,et al.  NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease , 2018, Alzheimer's & Dementia.

[32]  Alzheimer’s Association.  2018 Alzheimer's disease facts and figures , 2018, Alzheimer's & Dementia.

[33]  C. Finch,et al.  A critical review of assays for hazardous components of air pollution. , 2018, Free radical biology & medicine.

[34]  Andrew J. Saykin,et al.  Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer disease: a longitudinal study , 2018, The Lancet Neurology.

[35]  R. Whitmer,et al.  Post-traumatic stress disorder and risk of dementia among members of a health care delivery system , 2018, Alzheimer's & Dementia.

[36]  R. Kotov,et al.  Cognitive impairment among World Trade Center responders: Long-term implications of re-experiencing the 9/11 terrorist attacks , 2016, Alzheimer's & dementia.

[37]  T. Baram,et al.  Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐AD mice , 2015, Journal of neurochemistry.

[38]  M. Lippmann,et al.  Health effects of World Trade Center (WTC) Dust: An unprecedented disaster with inadequate risk management , 2015, Critical reviews in toxicology.

[39]  R. Pitman,et al.  Stress, PTSD, and dementia , 2014, Alzheimer's & Dementia.

[40]  S. Clouston,et al.  The role of defamilialization in the relationship between partnership and self-rated health: a cross-national comparison of Canada and the United States. , 2012, Social science & medicine.

[41]  Y. Neria,et al.  Posttraumatic stress disorder following the September 11, 2001, terrorist attacks: a review of the literature among highly exposed populations. , 2011, The American psychologist.

[42]  Nick C Fox,et al.  The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[43]  J. Morris,et al.  The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease , 2011, Alzheimer's & Dementia.

[44]  P. Georgopoulos,et al.  The Anatomy of the Exposures That Occurred around the World Trade Center Site , 2006, Annals of the New York Academy of Sciences.

[45]  J. Cummings,et al.  The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[46]  H. Brodaty,et al.  ALZHEIMER'S DISEASE INTERNATIONAL , 1997, International journal of geriatric psychiatry.