Melatonin prevents peritoneal adhesions in rats

Background and Aim:  Intra‐abdominal adhesions are important postoperative complications following abdominal surgery. The adhesions that develop form the basis of more advanced pathology such as intestinal obstruction or infertility. Melatonin is secreted from the pineal gland in a circadian pattern; this molecule has potent antioxidant characteristics and has beneficial effects in many models of inflammation. The aim of this study was to evaluate the effects of melatonin on peritoneal adhesions created in rats.

[1]  R. Reiter,et al.  Clinical aspects of melatonin. , 2008, Saudi medical journal.

[2]  R. Reiter,et al.  Biogenic amines in the reduction of oxidative stress: melatonin and its metabolites. , 2008, Neuro endocrinology letters.

[3]  J. Jeekel,et al.  Biology of the peritoneum in normal homeostasis and after surgical trauma , 2007, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[4]  D. Greenhalgh,et al.  Cutaneous Wound Healing , 2007, Journal of burn care & research : official publication of the American Burn Association.

[5]  R. Reiter,et al.  Medical implications of melatonin: receptor-mediated and receptor-independent actions. , 2007, Advances in medical sciences.

[6]  C. V. van Eijck,et al.  The role of neutrophils and oxygen free radicals in post-operative adhesions. , 2006, The Journal of surgical research.

[7]  H. Kırımlıoğlu,et al.  Protective effect of melatonin against oxidative stress on adhesion formation in the rat cecum and uterine horn model. , 2005, Life sciences.

[8]  N. Ilhan,et al.  Effect of melatonin on wound healing in normal and pinealectomized rats. , 2005, The Journal of surgical research.

[9]  Vanesa Martín,et al.  Regulation of antioxidant enzymes: a significant role for melatonin , 2004, Journal of pineal research.

[10]  S. Mutsaers Mesothelial Cell , 2020, Definitions.

[11]  S. Mutsaers,et al.  Stimulation of mesothelial cell proliferation by exudate macrophages enhances serosal wound healing in a murine model. , 2002, The American journal of pathology.

[12]  W L Ledger,et al.  Peritoneal healing and adhesion formation/reformation. , 2001, Human reproduction update.

[13]  C. Dervenis,et al.  Peritoneal Adhesions: Etiology, Pathophysiology, and Clinical Significance , 2001, Digestive Surgery.

[14]  J. Matés,et al.  Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. , 2000, Toxicology.

[15]  T. Kooistra,et al.  Use of fibrinolytic agents in the prevention of postoperative adhesion formation. , 2000, Fertility and sterility.

[16]  R. Reiter,et al.  Melatonin and Its Relation to the Immune System and Inflammation , 2000, Annals of the New York Academy of Sciences.

[17]  B. Callaghan The effect of pinealectomy on the crypts of defunctioned rat colon , 1997, Journal of pineal research.

[18]  I. Sayek,et al.  Effects of Polyglycolic Acid and Polypropylene Meshes on Postoperative Adhesion Formation in Mice , 1997, World Journal of Surgery.

[19]  C. Enwemeka,et al.  A simplified method for the analysis of hydroxyproline in biological tissues. , 1996, Clinical biochemistry.

[20]  J. Drobnik,et al.  Melatonin suppresses the pinealectomy-induced elevation of collagen content in a wound. , 1996, Cytobios.

[21]  M. Berker,et al.  The effect of the pineal gland on liver regeneration in rats. , 1995, Journal of hepatology.

[22]  T. Hendriks,et al.  Healing of experimental intestinal anastomoses , 1990, Diseases of the colon and rectum.

[23]  Y. Sun,et al.  A simple method for clinical assay of superoxide dismutase. , 1988, Clinical chemistry.

[24]  P. Flecknell,et al.  Experimental and surgical technique in the rat. , 1980 .

[25]  K. Yagi,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. , 1979, Analytical biochemistry.

[26]  O. H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.