Automatic identification of Mild Cognitive Impairment through the analysis of Italian spontaneous speech productions

This paper presents some preliminary results of the OPLON project. It aimed at identifying early linguistic symptoms of cognitive decline in the elderly. This pilot study was conducted on a corpus composed of spontaneous speech sample collected from 39 subjects, who underwent a neuropsychological screening for visuo-spatial abilities, memory, language, executive functions and attention. A rich set of linguistic features was extracted from the digitalised utterances (at phonetic, suprasegmental, lexical, morphological and syntactic levels) and the statistical significance in pinpointing the pathological process was measured. Our results show remarkable trends for what concerns both the linguistic traits selection and the automatic classifiers building.

[1]  Fabio Tamburini,et al.  Should we screen for cognitive decline and dementia? , 2015, Maturitas.

[2]  D. Holmes,et al.  A stylometric analysis of conversational speech of aphasic patients , 1996 .

[3]  Peter Garrard,et al.  Cognitive archaeology: Uses, methods, and results , 2009, Journal of Neurolinguistics.

[4]  Carlo Caltagirone,et al.  Batteria per la valutazione del Deterioramento Mentale (parte II): standardizzazione e affidabilità diagnostica nell’identificazione di pazienti affetti da sindrome demenziale , 1995 .

[5]  J. Cummings,et al.  The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment , 2005, Journal of the American Geriatrics Society.

[6]  Brian Roark,et al.  Syntactic complexity measures for detecting Mild Cognitive Impairment , 2007, BioNLP@ACL.

[7]  Dimitra Vergyri,et al.  Learning diagnostic models using speech and language measures , 2008, 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[8]  N. Cercone,et al.  Automatic detection and rating of dementia of Alzheimer type through lexical analysis of spontaneous speech , 2005, IEEE International Conference Mechatronics and Automation, 2005.

[9]  J. Lindesay,et al.  Review of brief cognitive tests for patients with suspected dementia , 2014, International Psychogeriatrics.

[10]  Henry Brodaty,et al.  The validation of the Italian version of the GPCOG (GPCOG-It): a contribution to cross-national implementation of a screening test for dementia in general practice , 2009, International Psychogeriatrics.

[11]  Eric Yeh,et al.  Language Analytics for Assessing Brain Health: Cognitive Impairment, Depression and Pre-symptomatic Alzheimer's Disease , 2010, Brain Informatics.

[12]  D R Wekstein,et al.  Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study. , 1996, JAMA.

[13]  Romola S. Bucks,et al.  Analysis of spontaneous, conversational speech in dementia of Alzheimer type: Evaluation of an objective technique for analysing lexical performance , 2000 .

[14]  Zahinoor Ismail,et al.  Brief cognitive screening instruments: an update , 2010, International journal of geriatric psychiatry.

[15]  Marcella Laiacona,et al.  Montreal Cognitive Assessment (MoCA)-Italian version: regression based norms and equivalent scores , 2015, Neurological Sciences.

[16]  Cristina Bosco,et al.  Building a Treebank for Italian: a Data-driven Annotation Schema , 2000, LREC.

[17]  Marcos Faúndez-Zanuy,et al.  On the Selection of Non-Invasive Methods Based on Speech Analysis Oriented to Automatic Alzheimer Disease Diagnosis , 2013, Sensors.

[18]  D. Selkoe.  Alzheimer's disease. , 2011, Cold Spring Harbor perspectives in biology.

[19]  Renne Alegria,et al.  Comparative study of the uses of grammatical categories: Adjectives, adverbs, pronouns, interjections, conjunctions and prepositions in patients with Alzheimer's disease , 2013, Alzheimer's & Dementia.

[20]  L. Mansur,et al.  Language and Communication Disorders in Dementia of the Alzheimer Type , 1998 .

[21]  Marc M Budge,et al.  Predicting cognitive decline in healthy older adults. , 2005, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.

[22]  H. Brodaty,et al.  The GPCOG: A New Screening Test for Dementia Designed for General Practice , 2002, Journal of the American Geriatrics Society.

[23]  E. Grabe,et al.  Durational variability in speech and the rhythm class hypothesis , 2005 .

[24]  K. Tsoi,et al.  Cognitive Tests to Detect Dementia: A Systematic Review and Meta-analysis. , 2015, JAMA internal medicine.

[25]  F. Ramus,et al.  Correlates of linguistic rhythm in the speech signal , 1999, Cognition.

[26]  Benedikt Szmrecsanyi,et al.  On operationalizing syntactic complexity , 2004 .

[27]  Giuseppe Zappalà,et al.  The mini‐mental state examination: Normative study of an Italian random sample , 1993 .

[28]  Yiannis Kompatsiaris,et al.  Evaluation of speech-based protocol for detection of early-stage dementia , 2013, INTERSPEECH.

[29]  Gloria Gagliardi.  Validazione dell’ontologia dell’azione IMAGACT per lo studio e la diagnosi del Mild Cognitive Impairment (MCI) , 2014 .

[30]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[31]  D. Holmes.  A Stylometric Analysis of Mormon Scripture and Related Texts , 1992 .

[32]  Michael A Covington,et al.  Automatic measurement of propositional idea density from part-of-speech tagging , 2008, Behavior research methods.

[33]  J. Semple,et al.  Paired associate performance in the early detection of DAT , 2002, Journal of the International Neuropsychological Society.

[34]  Sameer Singh,et al.  Evaluation of an objective technique for analysing temporal variables in DAT spontaneous speech , 2001 .

[35]  T. Robbins,et al.  Early Detection and Differential Diagnosis of Alzheimer’s Disease and Depression with Neuropsychological Tasks , 2001, Dementia and Geriatric Cognitive Disorders.

[36]  Gábor Gosztolya,et al.  Automatic detection of mild cognitive impairment from spontaneous speech using ASR , 2015, INTERSPEECH.

[37]  G. Wells,et al.  Clock Drawing: A Neuropsychological Analysis , 1995 .

[38]  J. Hodges,et al.  The effects of very early Alzheimer's disease on the characteristics of writing by a renowned author. , 2004, Brain : a journal of neurology.

[39]  V. Dellwo.  Rhythm and Speech Rate: A Variation Coefficient for deltaC , 2006 .

[40]  Andrew D. Blackwell,et al.  Detecting Dementia: Novel Neuropsychological Markers of Preclinical Alzheimer’s Disease , 2003, Dementia and Geriatric Cognitive Disorders.

[41]  Gustav Eje Henter,et al.  Proc. Interspeech 2012 , 2012, Interspeech.

[42]  Kathleen C. Fraser,et al.  Automated classification of primary progressive aphasia subtypes from narrative speech transcripts , 2014, Cortex.

[43]  Marcella Laiacona,et al.  Tre test clinici di ricerca e produzione lessicale , 1986 .

[44]  Vanessa Taler,et al.  Language performance in Alzheimer's disease and mild cognitive impairment: A comparative review , 2008, Journal of clinical and experimental neuropsychology.

[45]  Giulia Venturi,et al.  Tecnologie del linguaggio e monitoraggio dell’evoluzione delle abilità di scrittura nella scuola secondaria di primo grado , 2015 .

[46]  Colleen Richey,et al.  Aided diagnosis of dementia type through computer-based analysis of spontaneous speech , 2014, CLPsych@ACL.

[47]  M. Freedman,et al.  Clock Drawing: A Neuropsychological Analysis , 1994 .

[48]  G. Devoto,et al.  Il dizionario della lingua italiana , 1990 .

[49]  David A. Snowdon,et al.  Healthy Aging and Dementia: Findings from the Nun Study , 2003, Annals of Internal Medicine.

[50]  P. Pattison,et al.  The uses of nouns and deixis in discourse production in Alzheimer's disease , 2006, Journal of Neurolinguistics.

[51]  Maurizio Omologo,et al.  Speaker independent continuous speech recognition using an acoustic-phonetic Italian corpus , 1994, ICSLP.

[52]  Myron Weiner,et al.  Discourse Changes in Early Alzheimer Disease, Mild Cognitive Impairment, and Normal Aging , 2002, Alzheimer disease and associated disorders.

[53]  Alexander Sorin,et al.  Vocal Biomarkers for Dementia Patient Monitoring , 2013 .

[54]  R. Lipton,et al.  Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease , 2008, Journal of the International Neuropsychological Society.

[55]  Man-Wai Mak,et al.  A study of voice activity detection techniques for NIST speaker recognition evaluations , 2014, Comput. Speech Lang..

[56]  Brian Roark,et al.  Spoken Language Derived Measures for Detecting Mild Cognitive Impairment , 2011, IEEE Transactions on Audio, Speech, and Language Processing.