Molecular Pathophysiology of Gout.

[1]  H. Schumacher,et al.  Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. , 1988, Arthritis and rheumatism.

[2]  T. Pincus,et al.  Active and latent forms of transforming growth factor beta activity in synovial effusions , 1989, The Journal of experimental medicine.

[3]  M. Walport,et al.  Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages. , 1989, The Journal of clinical investigation.

[4]  J. Klein-Nulend,et al.  Natural and recombinant human IL-1 receptor antagonists block the effects of IL-1 on bone resorption and prostaglandin production. , 1990, Journal of immunology.

[5]  R. Thompson,et al.  The intratracheal administration of endotoxin and cytokines. III. The interleukin-1 (IL-1) receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation. , 1991, The American journal of pathology.

[6]  M. Feldmann,et al.  Induction of the interleukin 1 receptor antagonist protein by transforming growth factor‐β , 1991, European journal of immunology.

[7]  S. McColl,et al.  Human neutrophils produce high levels of the interleukin 1 receptor antagonist in response to granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha , 1992, The Journal of experimental medicine.

[8]  S. Wahl,et al.  Transforming growth factor-beta mediates IL-1-dependent induction of IL-1 receptor antagonist. , 1993, Journal of immunology.

[9]  M. Rola-Pleszczynski,et al.  Crystal-induced neutrophil activation. V. Differential production of biologically active IL-1 and IL-1 receptor antagonist. , 1994, Journal of immunology.

[10]  A. Mantovani,et al.  The type II 'decoy' receptor: a novel regulatory pathway for interleukin 1. , 1994, Immunology today.

[11]  A. Herbelin,et al.  Inhibition and prevention of monosodium urate monohydrate crystal-induced acute inflammation in vivo by transforming growth factor beta1. , 1996, Arthritis and rheumatism.

[12]  V. Fadok,et al.  Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. , 1998, The Journal of clinical investigation.

[13]  C. Dinarello The role of the interleukin-1-receptor antagonist in blocking inflammation mediated by interleukin-1. , 2000, The New England journal of medicine.

[14]  M. Schiff,et al.  Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis , 2000, Annals of the rheumatic diseases.

[15]  A. Masuda,et al.  Cutting Edge: Naturally Occurring Soluble Form of Mouse Toll-Like Receptor 4 Inhibits Lipopolysaccharide Signaling1 , 2000, The Journal of Immunology.

[16]  Do junvenile idiopathic arthritis patients benefit from an exercise program? A pilot study. , 2001, Arthritis and rheumatism.

[17]  M. Sweet,et al.  A Novel Pathway Regulating Lipopolysaccharide-Induced Shock by ST2/T1 Via Inhibition of Toll-Like Receptor 4 Expression1 , 2001, The Journal of Immunology.

[18]  J. Tschopp,et al.  Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88 , 2002, Current Biology.

[19]  Y. Murakami,et al.  Antiinflammatory effect of retrovirally transfected interleukin-10 on monosodium urate monohydrate crystal-induced acute inflammation in murine air pouches. , 2002, Arthritis and rheumatism.

[20]  D. Kastner,et al.  Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis. , 2003, Molecular cell.

[21]  Su-Hua Huang,et al.  A case-control study of the association of diet and obesity with gout in Taiwan. , 2003, The American journal of clinical nutrition.

[22]  James E. Evans,et al.  Molecular identification of a danger signal that alerts the immune system to dying cells , 2003, Nature.

[23]  K. Miyake,et al.  Interaction of Soluble Form of Recombinant Extracellular TLR4 Domain with MD-2 Enables Lipopolysaccharide Binding and Attenuates TLR4-Mediated Signaling1 , 2004, The Journal of Immunology.

[24]  J. Schifferli,et al.  Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. , 2004, Blood.

[25]  C. Serhan,et al.  Molecular Circuits of Resolution: Formation and Actions of Resolvins and Protectins1 , 2005, The Journal of Immunology.

[26]  A. Yoshimura,et al.  Negative regulation of cytokine signaling and immune responses by SOCS proteins , 2005, Arthritis research & therapy.

[27]  F. Martinon,et al.  Gout-associated uric acid crystals activate the NALP3 inflammasome , 2006, Nature.

[28]  K. Fritsche Fatty acids as modulators of the immune response. , 2006, Annual review of nutrition.

[29]  M. Hayakawa,et al.  ST2 suppresses IL-6 production via the inhibition of IkappaB degradation induced by the LPS signal in THP-1 cells. , 2006, Biochemical and biophysical research communications.

[30]  J. Harton,et al.  Pyrin-Only Protein 2 Modulates NF-κB and Disrupts ASC:CLR Interactions , 2007, The Journal of Immunology.

[31]  J. Mages,et al.  A genome-wide analysis of LPS tolerance in macrophages. , 2008, Immunobiology.

[32]  J. Tschopp,et al.  A pilot study of IL-1 inhibition by anakinra in acute gout , 2007, Arthritis research & therapy.

[33]  A. Mansell,et al.  The negative regulation of Toll‐like receptor and associated pathways , 2007, Immunology and cell biology.

[34]  Geoff Bellingan,et al.  Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyΔ12–14 PGJ2 , 2007, Proceedings of the National Academy of Sciences.

[35]  C. Stehlik,et al.  COPs and POPs: Modulators of Inflammasome Activity1 , 2007, The Journal of Immunology.

[36]  P. Lamprecht,et al.  Neue Aspekte zur Pathogenese der Gicht , 2008, Zeitschrift für Rheumatologie.

[37]  C. Hess,et al.  Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells1 , 2008, The Journal of Immunology.

[38]  A. Till,et al.  [New aspects of the pathogenesis of gout. Danger signals, autoinflammation and beyond]. , 2008, Zeitschrift fur Rheumatologie.

[39]  S. Yamasaki,et al.  Mincle is an ITAM-coupled activating receptor that senses damaged cells , 2008, Nature Immunology.

[40]  Karan Sharma,et al.  Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. , 2008, Immunity.

[41]  Jun Xu,et al.  Extracellular histones are major mediators of death in sepsis , 2009, Nature Medicine.

[42]  S. Biswas,et al.  Endotoxin tolerance: new mechanisms, molecules and clinical significance. , 2009, Trends in immunology.

[43]  L. Wahl,et al.  Endotoxin tolerance dysregulates MyD88‐ and Toll/IL‐1R domain‐containing adapter inducing IFN‐β‐dependent pathways and increases expression of negative regulators of TLR signaling , 2009, Journal of leukocyte biology.

[44]  K. Scalapino,et al.  Case of anakinra as a steroid-sparing agent for gout inflammation. , 2009, Arthritis and rheumatism.

[45]  R. Terkeltaub,et al.  The interleukin 1 inhibitor rilonacept in treatment of chronic gouty arthritis: results of a placebo-controlled, monosequence crossover, non-randomised, single-blind pilot study , 2009, Annals of the rheumatic diseases.

[46]  J. Scher,et al.  The Anti-Inflammatory Effects of Prostaglandins , 2009, Journal of Investigative Medicine.

[47]  J. Holroyd-Leduc,et al.  Acute monoarthritis: What is the cause of my patient's painful swollen joint? , 2009, Canadian Medical Association Journal.

[48]  Y. Zhang,et al.  Endotoxin Tolerance of RAW264.7 Correlates with p38-dependent Up-regulation of Scavenger Receptor-A , 2009, The Journal of international medical research.

[49]  Jillian Cornish,et al.  Cellular characterization of the gouty tophus: a quantitative analysis. , 2010, Arthritis and rheumatism.

[50]  S. Sadallah,et al.  Ectosomes Released by Polymorphonuclear Neutrophils Induce a MerTK-dependent Anti-inflammatory Pathway in Macrophages* , 2010, The Journal of Biological Chemistry.

[51]  K. Lauber,et al.  Sodium Overload and Water Influx Activate the NALP3 Inflammasome , 2010, The Journal of Biological Chemistry.

[52]  J. Sévigny,et al.  Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro. , 2010, Molecular immunology.

[53]  B. Palmer,et al.  Interleukin 37 is a fundamental inhibitor of innate immunity , 2010, Nature Immunology.

[54]  T. Neogi Clinical practice. Gout. , 2011, The New England journal of medicine.

[55]  Shin-Seok Lee,et al.  Bone destruction by receptor activator of nuclear factor κB ligand-expressing T cells in chronic gouty arthritis , 2011, Arthritis research & therapy.

[56]  Roddy Edward,et al.  Gout , 2011 .

[57]  Cheng-Han Wu,et al.  Spontaneous resolution of acute gouty arthritis is associated with rapid induction of the anti-inflammatory factors TGFβ1, IL-10 and soluble TNF receptors and the intracellular cytokine negative regulators CIS and SOCS3 , 2011, Annals of the rheumatic diseases.

[58]  C. Jun,et al.  Eupatilin inhibits lipopolysaccharide-induced expression of inflammatory mediators in macrophages. , 2011, Life sciences.

[59]  S. Steiger,et al.  Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout. , 2011, Arthritis and rheumatism.

[60]  R. Terkeltaub,et al.  2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis , 2012, Arthritis care & research.

[61]  L. Punzi,et al.  Cytokine levels in human synovial fluid during the different stages of acute gout: role of transforming growth factor β1 in the resolution phase , 2012, Annals of the rheumatic diseases.

[62]  P. Thompson,et al.  Activation of PAD4 in NET formation , 2012, Front. Immun..

[63]  Charles King,et al.  2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia , 2012, Arthritis care & research.

[64]  M. Spite,et al.  Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. , 2012, Annual review of nutrition.

[65]  Richard A. Flavell,et al.  Inflammasomes in health and disease , 2012, Nature.

[66]  G. Gamble,et al.  The Effects of Monosodium Urate Monohydrate Crystals on Chondrocyte Viability and Function: Implications for Development of Cartilage Damage in Gout , 2013, The Journal of Rheumatology.

[67]  Kazuro Furukawa,et al.  TLR4–MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide , 2013, Proceedings of the National Academy of Sciences.

[68]  C. Reis e Sousa,et al.  Sensing of cell death by myeloid C-type lectin receptors. , 2013, Current opinion in immunology.

[69]  Zhigang Tian,et al.  Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. , 2013, Immunity.

[70]  M. Röhm,et al.  NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury , 2013, Front. Immunol..

[71]  B. Fadeel,et al.  Macrophage Clearance of Neutrophil Extracellular Traps Is a Silent Process , 2013, The Journal of Immunology.

[72]  S. Steiger,et al.  Neutrophil cannibalism triggers transforming growth factor β1 production and self regulation of neutrophil inflammatory function in monosodium urate monohydrate crystal-induced inflammation in mice. , 2013, Arthritis and rheumatism.

[73]  G. Gardner,et al.  Treatment of Acute Gouty Arthritis in Complex Hospitalized Patients With Anakinra , 2013, Arthritis care & research.

[74]  B. Stockwell,et al.  Regulated cell death and inflammation: an auto-amplification loop causes organ failure , 2014, Nature Reviews Immunology.

[75]  K. Nakagomi,et al.  Proteomic Analysis to Examine the Role of Matrix Proteins in a Gouty Tophus from a Patient with Recurrent Gout , 2014, Nucleosides, nucleotides & nucleic acids.

[76]  G. Berry,et al.  T Cell–Macrophage Interactions and Granuloma Formation in Vasculitis , 2014, Front. Immunol..

[77]  T. Harrer,et al.  Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines , 2014, Nature Medicine.

[78]  B. Kuster,et al.  Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. , 2014, Immunity.

[79]  P. Vandenabeele,et al.  Regulated necrosis: the expanding network of non-apoptotic cell death pathways , 2014, Nature Reviews Molecular Cell Biology.

[80]  P. Detampel,et al.  Activation of NLRP3 inflammasome by crystalline structures via cell surface contact , 2014, Scientific Reports.

[81]  W. Robinson,et al.  Contribution of Mast Cell–Derived Interleukin‐1β to Uric Acid Crystal–Induced Acute Arthritis in Mice , 2014, Arthritis & rheumatology.

[82]  Mei Zeng,et al.  IL-37 inhibits the production of pro-inflammatory cytokines in MSU crystal-induced inflammatory response , 2016, Clinical Rheumatology.

[83]  H. Anders,et al.  Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN. , 2015, Journal of the American Society of Nephrology : JASN.

[84]  E. Gertner,et al.  Anakinra for the treatment of acute severe gout in critically ill patients. , 2015, Seminars in arthritis and rheumatism.

[85]  G. Schett,et al.  Why does the gout attack stop? A roadmap for the immune pathogenesis of gout , 2015, RMD Open.

[86]  Joo-Hyun Lee,et al.  Application of a Novel Diagnostic Rule in the Differential Diagnosis between Acute Gouty Arthritis and Septic Arthritis , 2015, Journal of Korean medical science.

[87]  A. Dumusc,et al.  Interleukin-1 as a therapeutic target in gout , 2015, Current opinion in rheumatology.

[88]  A. Aouba,et al.  Efficacy of Anakinra for Various Types of Crystal-Induced Arthritis in Complex Hospitalized Patients: A Case Series and Review of the Literature , 2015, Mediators of inflammation.

[89]  O. Shaw,et al.  Role of miR-146a in regulation of the acute inflammatory response to monosodium urate crystals , 2015, Annals of the rheumatic diseases.

[90]  N. Dalbeth,et al.  The Gouty Tophus: a Review , 2015, Current Rheumatology Reports.

[91]  J. Schifferli,et al.  Neutrophil microvesicles resolve gout by inhibiting C5a-mediated priming of the inflammasome , 2015, Annals of the rheumatic diseases.

[92]  E. Latz,et al.  Crystal Formation in Inflammation. , 2016, Annual review of immunology.

[93]  B. Beutler,et al.  NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component , 2015, Nature Immunology.

[94]  J. Hahn,et al.  Neutrophils and neutrophil extracellular traps orchestrate initiation and resolution of inflammation. , 2016, Clinical and experimental rheumatology.

[95]  G. Núñez,et al.  Nek7 is an essential mediator of NLRP3 activation downstream of potassium efflux , 2016, Nature.

[96]  H. Anders,et al.  Necroinflammation in Kidney Disease. , 2016, Journal of the American Society of Nephrology.

[97]  Xiaoxia Zhu,et al.  Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout , 2016, Arthritis Research & Therapy.

[98]  M. Gutierrez,et al.  Monosodium urate crystals induce oxidative stress in human synoviocytes , 2016, Arthritis Research & Therapy.

[99]  Balázs Rada,et al.  Macrophage-derived IL-1β enhances monosodium urate crystal-triggered NET formation , 2016, Inflammation Research.

[100]  Rostyslav Bilyy,et al.  Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis , 2016, Nature Communications.

[101]  H. Anders,et al.  PMA and crystal‐induced neutrophil extracellular trap formation involves RIPK1‐RIPK3‐MLKL signaling , 2016, European journal of immunology.

[102]  Trevor A. Mori,et al.  Specialised pro-resolving mediators of inflammation in inflammatory arthritis. , 2016, Prostaglandins, leukotrienes, and essential fatty acids.

[103]  Wen-tian He,et al.  Necrosome core machinery: MLKL , 2016, Cellular and Molecular Life Sciences.

[104]  J. M. Brauner,et al.  New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation , 2016, Front. Immunol..

[105]  L. Joosten,et al.  Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases , 2015, Annals of the rheumatic diseases.

[106]  L. Macia,et al.  Dietary fiber and the short‐chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice , 2017, Journal of leukocyte biology.

[107]  J. Sokolove,et al.  P2Y6 Receptor Antagonist MRS2578 Inhibits Neutrophil Activation and Aggregated Neutrophil Extracellular Trap Formation Induced by Gout-Associated Monosodium Urate Crystals , 2017, The Journal of Immunology.

[108]  B. Mandell,et al.  Update on Crystal-Induced Arthritides. , 2017, Clinics in geriatric medicine.

[109]  M. Doherty,et al.  Gout - a guide for the general and acute physicians. , 2017, Clinical medicine.