Abnormal regional spontaneous neuronal activity associated with symptom severity in treatment-naive patients with obsessive-compulsive disorder revealed by resting-state functional MRI

A large number of neuroimaging studies have revealed the dysfunction of brain activities in obsessive-compulsive disorder (OCD) during various tasks. However, regional spontaneous activity abnormalities in OCD are gradually being revealed. In this current study, we aimed to investigate cerebral regions with abnormal spontaneous activity using resting-state functional magnetic resonance imaging (fMRI) and further explored the relationship between the spontaneous neuronal activity and symptom severity of patients with OCD. Thirty-one patients with OCD and 32 age-and sex-matched normal controls received the fMRI scans and fractional amplitude of low-frequency fluctuation (fALFF) approach was applied to identify the abnormal brain activity. We found that patients with OCD showed decreased fALFF not only in the cortical-striato-thalamo-cortical (CSTC) circuits like the thalamus, but also in other cerebral systems like the cerebellum, the parietal cortex and the temporal cortex. Additionally, OCD patients demonstrated significant associations between decreased fALFF and obsessive-compulsive symptom severity in the thalamus, the paracentral lobule and the cerebellum. Our results provide evidence for abnormal spontaneous neuronal activity in distributed cerebral areas and support the notion that brain areas outside the CSTC circuits may also play an important role in the pathophysiology of OCD.

[1]  M. Pompili,et al.  Functional Neuroimaging in Obsessive-Compulsive Disorder , 2011, Neuropsychobiology.

[2]  Fuquan Zhang,et al.  Abnormal functional connectivity of brain network hubs associated with symptom severity in treatment-naive patients with obsessive–compulsive disorder: A resting-state functional MRI study , 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[3]  P. Videbech,et al.  Increased fractional anisotropy in cerebellum in obsessive–compulsive disorder , 2015, Acta Neuropsychiatrica.

[4]  Natasha M. Maurits,et al.  Correlating the alpha rhythm to BOLD using simultaneous EEG/fMRI: Inter-subject variability , 2006, NeuroImage.

[5]  W. T. Thach,et al.  Motor mechanisms of the CNS: cerebrocerebellar interrelations. , 1969, Annual review of physiology.

[6]  實松 寛晋.  Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder : an fMRI study , 2010 .

[7]  Shanbao Tong,et al.  Altered intrinsic insular activity predicts symptom severity in unmedicated obsessive-compulsive disorder patients: a resting state functional magnetic resonance imaging study , 2016, BMC Psychiatry.

[8]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[9]  W. Goodman,et al.  The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. , 1989, Archives of general psychiatry.

[10]  Yufeng Zang,et al.  DPARSF: A MATLAB Toolbox for “Pipeline” Data Analysis of Resting-State fMRI , 2010 .

[11]  Binbin Nie,et al.  Abnormal Resting-State Activities and Functional Connectivities of the Anterior and the Posterior Cortexes in Medication-Naïve Patients with Obsessive-Compulsive Disorder , 2013, PloS one.

[12]  P. Girardi,et al.  Executive functions in obsessive–compulsive disorder: An activation likelihood estimate meta-analysis of fMRI studies , 2016, The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry.

[13]  E. Bullmore,et al.  Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited , 2008, Neuroscience & Biobehavioral Reviews.

[14]  Kiyoshi Kurata,et al.  Activity properties and location of neurons in the motor thalamus that project to the cortical motor areas in monkeys. , 2005, Journal of neurophysiology.

[15]  P. Strick,et al.  Basal ganglia and cerebellar loops: motor and cognitive circuits , 2000, Brain Research Reviews.

[16]  M. Hamilton.  The assessment of anxiety states by rating. , 1959, The British journal of medical psychology.

[17]  R. C. Oldfield.  The assessment and analysis of handedness: the Edinburgh inventory. , 1971, Neuropsychologia.

[18]  Chaozhe Zhu,et al.  An improved approach to detection of amplitude of low-frequency fluctuation (ALFF) for resting-state fMRI: Fractional ALFF , 2008, Journal of Neuroscience Methods.

[19]  Feng Liu,et al.  Dissociation of functional and anatomical brain abnormalities in unaffected siblings of schizophrenia patients , 2015, Clinical Neurophysiology.

[20]  M. Hamilton,et al.  Development of a rating scale for primary depressive illness. , 1967, The British journal of social and clinical psychology.

[21]  T. Nakamae,et al.  Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder , 2011, European Psychiatry.

[22]  H. Groenewegen,et al.  The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems. , 2008, Brain : a journal of neurology.

[23]  Baoci Shan,et al.  Abnormal regional homogeneity of drug-naı¨ve obsessive-compulsive patients , 2010, Neuroreport.

[24]  B. Biswal,et al.  Functional connectivity in the motor cortex of resting human brain using echo‐planar mri , 1995, Magnetic resonance in medicine.

[25]  R. Lanius,et al.  Resting-State Neuroimaging Studies: A New Way of Identifying Differences and Similarities among the Anxiety Disorders? , 2014, Canadian journal of psychiatry. Revue canadienne de psychiatrie.

[26]  Ping Li,et al.  Altered resting state functional connectivity patterns of the anterior prefrontal cortex in obsessive-compulsive disorder , 2012, Neuroreport.

[27]  M. Lowe,et al.  Functional Connectivity in Single and Multislice Echoplanar Imaging Using Resting-State Fluctuations , 1998, NeuroImage.

[28]  Masao Ito.  Control of mental activities by internal models in the cerebellum , 2008, Nature Reviews Neuroscience.

[29]  T. León,et al.  Resting state in obsessive-compulsive disorder. A review of the literature. , 2014, Actas espanolas de psiquiatria.

[30]  Chaogan Yan,et al.  DPARSF: A MATLAB Toolbox for “Pipeline” Data Analysis of Resting-State fMRI , 2010, Front. Syst. Neurosci..

[31]  S. Rauch,et al.  Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways , 2012, Trends in Cognitive Sciences.

[32]  N. Kanwisher,et al.  Neuroimaging of cognitive functions in human parietal cortex , 2001, Current Opinion in Neurobiology.

[33]  Dan J Stein,et al.  The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication , 2010, Molecular Psychiatry.

[34]  Feng Liu,et al.  Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: A resting-state fMRI study , 2012, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[35]  Catherine J. Stoodley,et al.  Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing , 2010, Cortex.

[36]  D. Segal.  Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) , 2010 .

[37]  Jian Wang,et al.  Morphologic and Functional Connectivity Alterations of Corticostriatal and Default Mode Network in Treatment-Naïve Patients with Obsessive-Compulsive Disorder , 2013, PloS one.

[38]  V. Haughton,et al.  Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data. , 2001, AJNR. American journal of neuroradiology.

[39]  Orbito-frontal cortex and thalamus volumes in obsessive-compulsive disorder before and after pharmacotherapy , 2016, Brain Imaging and Behavior.

[40]  T. Insel,et al.  Toward a neuroanatomy of obsessive-compulsive disorder. , 1992, Archives of general psychiatry.

[41]  E. Bullmore,et al.  Mapping Motor Inhibition: Conjunctive Brain Activations across Different Versions of Go/No-Go and Stop Tasks , 2001, NeuroImage.

[42]  J. Abramowitz,et al.  Obsessive-compulsive disorder , 2006, The Lancet.

[43]  K. Sim,et al.  Meta-analytic investigations of structural grey matter, executive domain-related functional activations, and white matter diffusivity in obsessive compulsive disorder: An integrative review , 2015, Neuroscience & Biobehavioral Reviews.

[44]  S. Rauch,et al.  Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. , 2000, The Psychiatric clinics of North America.

[45]  Abraham Z. Snyder,et al.  Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion , 2012, NeuroImage.

[46]  Jian Wang,et al.  Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: a resting-state fMRI study. , 2012, Journal of affective disorders.

[47]  E. Katz,et al.  Cerebral glucose metabolism in obsessive-compulsive hoarding. , 2004, The American journal of psychiatry.