Structure and regulation of mammalian squalene synthase.
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[1] J. Sacchettini,et al. Creating Isoprenoid Diversity , 1997, Science.
[2] Crystal Structure of Human Squalene Synthase , 2000, The Journal of Biological Chemistry.
[3] I. Shechter,et al. Molecular cloning, expression, and characterization of the cDNA for the rat hepatic squalene synthase. , 1992, The Journal of biological chemistry.
[4] I. Shechter,et al. 2.09 – Squalene Synthase , 1999 .
[5] D. A. Dougherty,et al. Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp , 1996, Science.
[6] H. J. Harwood,et al. HMG-CoA reductase regulation: use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells. , 1999, Journal of lipid research.
[7] I. Shechter,et al. Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1. , 1994, Genomics.
[8] Joseph L Goldstein,et al. Regulated Intramembrane Proteolysis A Control Mechanism Conserved from Bacteria to Humans , 2000, Cell.
[9] Roger A. Davis,et al. Chapter 13 – Isoprenoids, sterols and bile acids , 1996 .
[10] C. Poulter,et al. Squalene synthetase. Inhibition by an ammonium analogue of a carbocationic intermediate in the conversion of presqualene pyrophosphate to squalene , 1982 .
[11] A. Qureshi,et al. Squalene Synthetase III. MECHANISM OF THE REACTION , 1973 .
[12] K. Mookhtiar,et al. Mechanism of inhibition of yeast squalene synthase by substrate analog inhibitors. , 1999, Archives of biochemistry and biophysics.
[13] R. Hammer,et al. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. , 1997, The Journal of clinical investigation.
[14] H. J. Harwood,et al. 3-(4-chlorophenyl)-2-(4-diethylaminoethoxyphenyl)-A-pentenonitrile monohydrogen citrate and related analogs. Reversible, competitive, first half-reaction squalene synthetase inhibitors. , 1997, Biochemical pharmacology.
[15] J. Noel,et al. Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase. , 1997, Science.
[16] David M. Rothwarf,et al. The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus , 1999, Science's STKE.
[17] I. Shechter,et al. Molecular Cloning and Functional Analysis of the Promoter of the Human Squalene Synthase Gene (*) , 1995, The Journal of Biological Chemistry.
[18] J C Sacchettini,et al. Regulation of product chain length by isoprenyl diphosphate synthases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[19] T. Osborne,et al. Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein* , 1998, The Journal of Biological Chemistry.
[20] I. Shimomura,et al. Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver* , 1998, The Journal of Biological Chemistry.
[21] I. Shimomura,et al. Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. , 1999, Current opinion in lipidology.
[22] P. Edwards,et al. Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity. , 1993, The Journal of biological chemistry.
[23] P. Edwards,et al. YY1 Is a Negative Regulator of Transcription of Three Sterol Regulatory Element-binding Protein-responsive Genes* , 1999, The Journal of Biological Chemistry.
[24] S. Cornell-Kennon,et al. Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems. , 1995, Archives of biochemistry and biophysics.
[25] F. Karst,et al. The regulation of activity of main mevalonic acid pathway enzymes: farnesyl diphosphate synthase, 3-hydroxy-3-methylglutaryl-CoA reductase, and squalene synthase in yeast Saccharomyces cerevisiae. , 2000, Biochemical and biophysical research communications.
[26] R. M. Sandifer,et al. SQUALENE SYNTHETASE. INHIBITION BY AN AMMONIUM ANALOG OF A CARBOCATIONIC INTERMEDIATE IN THE CONVERSION OF PRESQUALENE PYROPHOSPHATE TO SQUALENE , 1983 .
[27] J. Goldstein,et al. Regulation of the mevalonate pathway , 1990, Nature.
[28] I. Shimomura,et al. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[29] C. Poulter,et al. Chain elongation in the isoprenoid biosynthetic pathway. , 1997, Current opinion in chemical biology.
[30] K. Dooley,et al. A Critical Role for cAMP Response Element-binding Protein (CREB) as a Co-activator in Sterol-regulated Transcription of 3-Hydroxy-3-methylglutaryl Coenzyme A Synthase Promoter* , 1999, The Journal of Biological Chemistry.
[31] C. Poulter,et al. Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH. , 1994, The Journal of biological chemistry.
[32] D. Danley,et al. Crystal Structure of Human Squalene Synthase , 2000, The Journal of Biological Chemistry.
[33] K. Feingold,et al. Effects of endotoxin and cytokines on lipid metabolism. , 1994, Current opinion in lipidology.
[34] G. Robinson,et al. Molecular cloning and characterization of the yeast gene for squalene synthetase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[35] B. Camara,et al. Carotenoid biosynthesis: Isolation and characterization of a bifunctional enzyme catalyzing the synthesis of phytoene. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[36] J. Taylor,et al. Effect of endotoxin on cholesterol biosynthesis and distribution in serum lipoproteins in Syrian hamsters. , 1993, Journal of lipid research.
[37] K. Feingold,et al. Discordant regulation of proteins of cholesterol metabolism during the acute phase response. , 1995, Journal of lipid research.
[38] Manabu T. Nakamura,et al. Sterol Regulatory Element Binding Protein-1 Expression Is Suppressed by Dietary Polyunsaturated Fatty Acids , 1999, The Journal of Biological Chemistry.
[39] M. Brown,et al. Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL. , 1999, The Journal of clinical investigation.
[40] I. Shechter,et al. Function-Structure Studies and Identification of Three Enzyme Domains Involved in the Catalytic Activity in Rat Hepatic Squalene Synthase* , 1998, The Journal of Biological Chemistry.
[41] F. Karst,et al. Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase. , 1993, Gene.
[42] J. Hearst,et al. Genetics and molecular biology of carotenoid pigment biosynthesis , 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[43] K. Dooley,et al. Sterol Regulation of 3-Hydroxy-3-Methylglutaryl-coenzyme A Synthase Gene through a Direct Interaction Between Sterol Regulatory Element Binding Protein and the Trimeric CCAAT-binding Factor/Nuclear Factor Y* , 1998, The Journal of Biological Chemistry.
[44] M. Brown,et al. Squalene synthetase activity in human fibroblasts: regulation via the low density lipoprotein receptor. , 1979, Proceedings of the National Academy of Sciences of the United States of America.
[45] I. Shechter,et al. SULFOBETAINE ZWITTERIONIC INHIBITORS OF SQUALENE SYNTHASE , 1996 .
[46] M. Brown,et al. A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[47] X. Hua,et al. Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment , 1996, Cell.
[48] R. Hammer,et al. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. , 1996, The Journal of clinical investigation.
[49] Robert V Farese,et al. Genetic regulation of cholesterol homeostasis: chromosomal organization of candidate genes. , 1996, Journal of lipid research.
[50] G. Schulz,et al. The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution. , 1999, Journal of molecular biology.
[51] J. Goldstein,et al. The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor , 1997, Cell.
[52] C. Poulter,et al. Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[53] G. Bills,et al. Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase. , 1995, Annual Review of Microbiology.
[54] M. Brown,et al. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[55] D. Cane,et al. Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology. , 1997, Science.
[56] S. Perrey,et al. Embryonic Lethality and Defective Neural Tube Closure in Mice Lacking Squalene Synthase* , 1999, The Journal of Biological Chemistry.
[57] I. Shechter,et al. Solubilization, purification, and characterization of a truncated form of rat hepatic squalene synthetase. , 1992, The Journal of biological chemistry.
[58] C. Poulter. Biosynthesis of non-head-to-tail terpenes. Formation of 1'-1 and 1'-3 linkages , 1990 .
[59] I. Shechter,et al. Subcellular localization of squalene synthase in rat hepatic cells. Biochemical and immunochemical evidence. , 1993, The Journal of biological chemistry.
[60] M. Foretz,et al. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[61] H. Kleinig,et al. Light-dependent regulation of carotenoid biosynthesis occurs at the level of phytoene synthase expression and is mediated by phytochrome in Sinapis alba and Arabidopsis thaliana seedlings. , 1997, The Plant journal : for cell and molecular biology.
[62] T. Inoue,et al. Molecular cloning and functional expression of a cDNA for mouse squalene synthase. , 1995, Biochimica et biophysica acta.
[63] M. Brown,et al. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. , 1980, Journal of lipid research.
[64] J. Flier,et al. ADD-1 provides major new insight into the mechanism of insulin action. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[65] J. Goldstein,et al. Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins* , 1998, The Journal of Biological Chemistry.
[66] E. Radisky,et al. Squalene synthase: steady-state, pre-steady-state, and isotope-trapping studies. , 2000, Biochemistry.
[67] Jay D. Horton,et al. Increased Levels of Nuclear SREBP-1c Associated with Fatty Livers in Two Mouse Models of Diabetes Mellitus* , 1999, The Journal of Biological Chemistry.
[68] X. Hua,et al. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis , 1994, Cell.
[69] N. Misawa,et al. Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme , 1992, FEBS letters.
[70] I. Shechter,et al. Differential Transcriptional Regulation of the Human Squalene Synthase Gene by Sterol Regulatory Element-binding Proteins (SREBP) 1a and 2 and Involvement of 5′ DNA Sequence Elements in the Regulation* , 1998, Journal of Biological Chemistry.
[71] Timothy F. Osborne,et al. Multiple Sequence Elements are Involved in the Transcriptional Regulation of the Human Squalene Synthase Gene* , 1997, The Journal of Biological Chemistry.
[72] I. Shimomura,et al. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[73] J. Goldstein,et al. Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. , 1994, Genes & development.
[74] M. Bard,et al. Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae. , 1999, Biochimica et biophysica acta.
[75] T. Hamakubo,et al. The physiological role of sterol regulatory element-binding protein-2 in cultured human cells. , 1999, Biochimica et biophysica acta.
[76] K. Feingold,et al. Endotoxin, tumor necrosis factor, and interleukin-1 decrease hepatic squalene synthase activity, protein, and mRNA levels in Syrian hamsters. , 1997, Journal of lipid research.
[77] D. Vance,et al. Biochemistry of Lipids, Lipoproteins and Membranes , 2002 .
[78] R. Hammer,et al. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. , 1997, The Journal of clinical investigation.
[79] H. Rilling. The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture. , 1985, Biochemical Society transactions.
[80] P. Edwards,et al. Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein. , 1998, Journal of lipid research.
[81] T. Tansey,et al. Squalene synthase: structure and regulation. , 2001, Progress in nucleic acid research and molecular biology.
[82] T. Osborne,et al. Different Sterol Regulatory Element-binding Protein-1 Isoforms Utilize Distinct Co-regulatory Factors to Activate the Promoter for Fatty Acid Synthase* , 2000, The Journal of Biological Chemistry.
[83] J. Sacchettini,et al. Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution. , 1994, Biochemistry.
[84] I. Shimomura,et al. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. , 1997, The Journal of clinical investigation.
[85] R. Hammer,et al. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. , 1998, The Journal of clinical investigation.
[86] H. Rilling,et al. Purification to homogeneity and some properties of squalene synthetase. , 1988, Archives of Biochemistry and Biophysics.
[87] P. Procopiou,et al. Squalene synthase inhibitors: their potential as hypocholesterolaemic agents. , 1996, Progress in medicinal chemistry.
[88] I. Shechter,et al. Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase. , 1993, The Journal of biological chemistry.
[89] T. Osborne,et al. Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene (*) , 1995, The Journal of Biological Chemistry.
[90] J. Rosenfeld,et al. Co-stimulation of Promoter for Low Density Lipoprotein Receptor Gene by Sterol Regulatory Element-binding Protein and Sp1 Is Specifically Disrupted by the Yin Yang 1 Protein* , 1999, The Journal of Biological Chemistry.