Apelin-36 exerts the cytoprotective effect against MPP+-induced cytotoxicity in SH-SY5Y cells through PI3K/Akt/mTOR autophagy pathway.

[1]  Zhinian Lei,et al.  A30P mutant α-synuclein impairs autophagic flux by inactivating JNK signaling to enhance ZKSCAN3 activity in midbrain dopaminergic neurons , 2019, Cell Death & Disease.

[2]  Wei Liu,et al.  Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[3]  Ming Lu,et al.  MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson’s Disease , 2018, Front. Mol. Neurosci..

[4]  Qiong Zhang,et al.  Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[5]  S. Birman,et al.  The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain , 2018, Autophagy.

[6]  D. Truong,et al.  Levodopa-induced dyskinesia: clinical features, incidence, and risk factors , 2018, Journal of Neural Transmission.

[7]  Jinwook Shin,et al.  Inhibition of Mast Cell Function and Proliferation by mTOR Activator MHY1485 , 2018, Immune network.

[8]  Weifeng Huang,et al.  Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway , 2018, Neural regeneration research.

[9]  Youngil Lee,et al.  Endurance Exercise Mediates Neuroprotection Against MPTP-mediated Parkinson’s Disease via Enhanced Neurogenesis, Antioxidant Capacity, and Autophagy , 2018, Neuroscience.

[10]  L. O'Keefe,et al.  Using Drosophila Models of Amyloid Toxicity to Study Autophagy in the Pathogenesis of Alzheimer's Disease , 2018, BioMed research international.

[11]  I. Perrotta,et al.  Rapamycin-induced autophagy protects proximal tubular renal cells against proteinuric damage through the transcriptional activation of the nerve growth factor receptor NGFR , 2018, Autophagy.

[12]  P. Burgos,et al.  Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer’s Disease , 2018, Front. Cell. Neurosci..

[13]  V. Sheibani,et al.  Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats , 2018, Neuropeptides.

[14]  Pouresmaeili-BabakiElham,et al.  Protective Effect of Neuropeptide Apelin-13 on 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Dopaminergic Cells: Involvement of Its Antioxidant and Antiapoptotic Properties. , 2018 .

[15]  Qi Wang,et al.  Effect of moxibustion on mTOR-mediated autophagy in rotenone-induced Parkinson's disease model rats , 2018, Neural regeneration research.

[16]  A. Abramov,et al.  Mitochondrial calcium imbalance in Parkinson’s disease , 2017, Neuroscience Letters.

[17]  F. Fu,et al.  Hydroxysafflor yellow A promotes α-synuclein clearance via regulating autophagy in rotenone-induced Parkinson's disease mice. , 2018, Folia neuropathologica.

[18]  Bo Bai,et al.  Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke , 2017, Front. Neurol..

[19]  Jun Liu,et al.  DJ-1 Inhibits α-Synuclein Aggregation by Regulating Chaperone-Mediated Autophagy , 2017, Front. Aging Neurosci..

[20]  B. Wieringa,et al.  The SH-SY5Y cell line in Parkinson’s disease research: a systematic review , 2017, Molecular Neurodegeneration.

[21]  Kawinthra Khwanraj,et al.  Comparative mRNA Expression of eEF1A Isoforms and a PI3K/Akt/mTOR Pathway in a Cellular Model of Parkinson's Disease , 2016, Parkinson's disease.

[22]  M. Xilouri,et al.  Autophagy and Alpha‐Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies , 2016, Movement disorders : official journal of the Movement Disorder Society.

[23]  G. Deuschl,et al.  MDS clinical diagnostic criteria for Parkinson's disease , 2015, Movement disorders : official journal of the Movement Disorder Society.

[24]  Xiao-Min Wang,et al.  GBA deficiency promotes SNCA/α-synuclein accumulation through autophagic inhibition by inactivated PPP2A , 2015, Autophagy.

[25]  Manuel Rodriguez,et al.  The degeneration of dopaminergic synapses in Parkinson's disease: A selective animal model , 2015, Behavioural Brain Research.

[26]  E. Masliah,et al.  Autophagy in Alzheimer’s disease , 2015, Reviews in the neurosciences.

[27]  C. Richter-Landsberg,et al.  Inhibition of UCH-L1 in oligodendroglial cells results in microtubule stabilization and prevents α-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system atrophy , 2015, Front. Cell. Neurosci..

[28]  Rui Huang,et al.  Identifying an essential role of nuclear LC3 for autophagy , 2015, Autophagy.

[29]  Bo Bai,et al.  Lateral intracerebroventricular injection of Apelin-13 inhibits apoptosis after cerebral ischemia/reperfusion injury , 2015, Neural regeneration research.

[30]  F. Cao,et al.  The role of the autophagy in myocardial ischemia/reperfusion injury. , 2015, Biochimica et biophysica acta.

[31]  Jing Chen,et al.  Neuroprotective effects of apelin-13 on experimental ischemic stroke through suppression of inflammation , 2015, Peptides.

[32]  Kyung‐Jin Min,et al.  Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons , 2014, Neurobiology of Aging.

[33]  S. Fulda Synthetic lethality by co-targeting mitochondrial apoptosis and PI3K/Akt/mTOR signaling. , 2014, Mitochondrion.

[34]  J. Schapansky,et al.  Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy. , 2014, Human molecular genetics.

[35]  C. Duan,et al.  Defective Autophagy in Parkinson’s Disease: Lessons from Genetics , 2014, Molecular Neurobiology.

[36]  D. Klionsky,et al.  An overview of autophagy: morphology, mechanism, and regulation. , 2014, Antioxidants & redox signaling.

[37]  C. Hetz,et al.  Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons , 2013, Autophagy.

[38]  L. Harhaji-Trajković,et al.  Autophagy-dependent and -independent involvement of AMP-activated protein kinase in 6-hydroxydopamine toxicity to SH-SY5Y neuroblastoma cells. , 2012, Biochimica et biophysica acta.

[39]  Bo Bai,et al.  Neuroprotection of apelin and its signaling pathway , 2012, Peptides.

[40]  Gang Wang,et al.  Kinases and kinase signaling pathways: Potential therapeutic targets in Parkinson's disease , 2012, Progress in Neurobiology.

[41]  J. T. Babcock,et al.  Rheb/mTOR activation and regulation in cancer: novel treatment strategies beyond rapamycin. , 2011, Current Drug Targets.

[42]  Kostas Vekrellis,et al.  Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells* , 2008, Journal of Biological Chemistry.

[43]  A. Davenport,et al.  Emerging roles of apelin in biology and medicine. , 2005, Pharmacology & therapeutics.

[44]  A. Björklund,et al.  Overexpression of Glial Cell Line-Derived Neurotrophic Factor Using a Lentiviral Vector Induces Time- and Dose-Dependent Downregulation of Tyrosine Hydroxylase in the Intact Nigrostriatal Dopamine System , 2004, The Journal of Neuroscience.

[45]  O. Nishimura,et al.  Molecular properties of apelin: tissue distribution and receptor binding. , 2001, Biochimica et biophysica acta.

[46]  O. Nishimura,et al.  Molecular and Functional Characteristics of APJ , 2000, The Journal of Biological Chemistry.

[47]  G. Rijkers,et al.  Insulin-like growth factor induces phosphorylation of immunoreactive insulin receptor substrate and its association with phosphatidylinositol-3 kinase in human thymocytes , 1995, The Journal of experimental medicine.