Machine Learning Can Predict Level of Improvement in Shoulder Arthroplasty

Background: The ability to accurately predict postoperative outcomes is of considerable interest in the field of orthopaedic surgery. Machine learning has been used as a form of predictive modeling in multiple health-care settings. The purpose of the current study was to determine whether machine learning algorithms using preoperative data can predict improvement in American Shoulder and Elbow Surgeons (ASES) scores for patients with glenohumeral osteoarthritis (OA) at a minimum of 2 years after shoulder arthroplasty. Methods: This was a retrospective cohort study that included 472 patients (472 shoulders) diagnosed with primary glenohumeral OA (mean age, 68 years; 56% male) treated with shoulder arthroplasty (431 anatomic total shoulder arthroplasty and 41 reverse total shoulder arthroplasty). Preoperative computed tomography (CT) scans were used to classify patients on the basis of glenoid and rotator cuff morphology. Preoperative and final postoperative ASES scores were used to assess the level of improvement. Patients were separated into 3 improvement ranges of approximately equal size. Machine learning methods that related patterns of these variables to outcome ranges were employed. Three modeling approaches were compared: a model with the use of all baseline variables (Model 1), a model omitting morphological variables (Model 2), and a model omitting ASES variables (Model 3). Results: Improvement ranges of ≤28 points (class A), 29 to 55 points (class B), and >55 points (class C) were established. Using all follow-up time intervals, Model 1 gave the most accurate predictions, with probability values of 0.94, 0.95, and 0.94 for classes A, B, and C, respectively. This was followed by Model 2 (0.93, 0.80, and 0.73) and Model 3 (0.77, 0.72, and 0.71). Conclusions: Machine learning can accurately predict the level of improvement after shoulder arthroplasty for glenohumeral OA. This may allow physicians to improve patient satisfaction by better managing expectations. These predictions were most accurate when latent variables were combined with morphological variables, suggesting that both patients’ perceptions and structural pathology are critical to optimizing outcomes in shoulder arthroplasty. Level of Evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

[1]  M. Swiontkowski,et al.  Measuring patient satisfaction in orthopaedic surgery. , 2015, The Journal of bone and joint surgery. American volume.

[2]  Jimeng Sun,et al.  Using recurrent neural network models for early detection of heart failure onset , 2016, J. Am. Medical Informatics Assoc..

[3]  J. Reginster,et al.  Patients’ Expectations Impact Their Satisfaction following Total Hip or Knee Arthroplasty , 2016, PloS one.

[4]  C. Gerber,et al.  Quantitative assessment of the muscles of the rotator cuff with magnetic resonance imaging. , 1998, Investigative radiology.

[5]  T. Neeman Clinical Prediction Models: A Practical Approach to Development, Validation, and Updating by Ewout W. Steyerberg , 2009 .

[6]  E. Smith,et al.  Fulfilment of preoperative expectations and postoperative patient satisfaction after total knee replacement. A prospective analysis of 200 patients. , 2019, The Knee.

[7]  W. Wallace,et al.  Use of scoring systems for assessing and reporting the outcome results from shoulder surgery and arthroplasty. , 2015, World journal of orthopedics.

[8]  G. Athwal,et al.  Rotator Cuff Fatty Infiltration and Atrophy Are Associated With Functional Outcomes in Anatomic Shoulder Arthroplasty , 2015, Clinical orthopaedics and related research.

[9]  R. Cofield,et al.  Shoulder arthroplasty in patients aged fifty-five years or younger with osteoarthritis. , 2011, Journal of shoulder and elbow surgery.

[10]  M. Frankle,et al.  The effects of glenoid wear patterns on patients with osteoarthritis in total shoulder arthroplasty: an assessment of outcomes and value. , 2015, Journal of shoulder and elbow surgery.

[11]  R. Warren,et al.  Effect of preoperative patient expectations on outcomes after reverse total shoulder arthroplasty. , 2018, Journal of shoulder and elbow surgery.

[12]  Sanjay Ranka,et al.  Machine learning approaches for predicting high cost high need patient expenditures in health care , 2018, BioMedical Engineering OnLine.

[13]  G. Walch,et al.  Morphologic study of the glenoid in primary glenohumeral osteoarthritis. , 1999, The Journal of arthroplasty.

[14]  R. Hawkins,et al.  Outcomes of Anatomic Total Shoulder Arthroplasty with B2 Glenoids: A Systematic Review , 2018, JBJS reviews.

[15]  M. Keith,et al.  Treatment of glenohumeral osteoarthritis. , 2010, The Journal of the American Academy of Orthopaedic Surgeons.

[16]  H. Koh,et al.  Data mining applications in healthcare. , 2005, Journal of healthcare information management : JHIM.

[17]  Jonathan C. Levy,et al.  Reverse shoulder arthroplasty for the treatment of rotator cuff deficiency. , 2008, The Journal of bone and joint surgery. American volume.

[18]  Brian T Feeley,et al.  Higher Patient Expectations Predict Higher Patient-Reported Outcomes, But Not Satisfaction, in Total Knee Arthroplasty Patients: A Prospective Multicenter Study. , 2017, The Journal of arthroplasty.

[19]  E. Craig,et al.  Effect of pre‐operative expectations on the outcomes following total shoulder arthroplasty , 2017, The bone & joint journal.

[20]  John W. Showalter,et al.  Using applied machine learning to predict healthcare utilization based on socioeconomic determinants of care. , 2020, The American journal of managed care.

[21]  G. Walch,et al.  Fatty infiltration of the supraspinatus: a reliability study. , 2009, Journal of shoulder and elbow surgery.

[22]  Ranjan Gupta,et al.  Biomechanical effects of glenoid retroversion in total shoulder arthroplasty. , 2007, Journal of shoulder and elbow surgery.

[23]  Max Kuhn,et al.  Applied Predictive Modeling , 2013 .

[24]  G. Walch,et al.  A modification to the Walch classification of the glenoid in primary glenohumeral osteoarthritis using three-dimensional imaging. , 2016, Journal of shoulder and elbow surgery.

[25]  D Goutallier,et al.  Fatty muscle degeneration in cuff ruptures. Pre- and postoperative evaluation by CT scan. , 1994, Clinical orthopaedics and related research.

[26]  S. MacDonald,et al.  The relationship between expectations and satisfaction in patients undergoing primary total knee arthroplasty. , 2012, The Journal of arthroplasty.

[27]  T. B. Edwards,et al.  A comparison of hemiarthroplasty and total shoulder arthroplasty in the treatment of primary glenohumeral osteoarthritis: results of a multicenter study. , 2003, Journal of shoulder and elbow surgery.

[28]  R. Hawkins,et al.  Supraspinatus atrophy as a predictor of rotator cuff tear size: an MRI study utilizing the tangent sign. , 2013, Journal of shoulder and elbow surgery.

[29]  A. Perruccio,et al.  Measuring Expectations in Orthopaedic Surgery: A Systematic Review , 2013, Clinical orthopaedics and related research.

[30]  Jun S. Kim,et al.  Predicting Surgical Complications in Patients Undergoing Elective Adult Spinal Deformity Procedures Using Machine Learning. , 2018 .

[31]  Abbas Toloie Eshlaghy,et al.  Using Three Machine Learning Techniques for Predicting Breast Cancer Recurrence , 2013 .

[32]  Gang Luo,et al.  Automatically explaining machine learning prediction results: a demonstration on type 2 diabetes risk prediction , 2016, Health Inf. Sci. Syst..

[33]  P Mansat,et al.  Evaluation of the glenoid implant survival using a biomechanical finite element analysis: influence of the implant design, bone properties, and loading location. , 2007, Journal of shoulder and elbow surgery.

[34]  J. Huddleston,et al.  Do Patient Expectations Influence Patient-Reported Outcomes and Satisfaction in Total Hip Arthroplasty? A Prospective, Multicenter Study. , 2017, The Journal of arthroplasty.