Comparison of Dynamic Susceptibility-weighted

EricS.Paulson,PhDKathleenM.Schmainda,PhDPurpose: To investigate whether estimates of relative cerebral blood vol-ume (rCBV) in brain tumors, obtained by using dynamic sus-ceptibility-weighted contrast material–enhanced magnetic res-onance (MR) imaging vary with choice of data acquisition andpostprocessing methods.Materials andMethods:Four acquisition methods were used to collect data in 22 high-grade glioma patients, with informed written consent underHIPAA-compliant guidelines approved by the institutional re-view board. During bolus administration of a standard singledose of gadolinium-based contrast agent (0.1 mmol per kilo-gram of body weight), one of three acquisition methods wasused: gradient-echo (GRE) echo-planar imaging (echo time[TE], 30 msec; flip angle, 90°;

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