WOUND HEALING EFFICACY OF HONEY, ALOE VERA, AND TURMERIC

Skin naturally acts as a body's protective layer and external environmental factors that can harm internal body organs are protected by it.So, maintaining skin integrity is vital for normal physiological functioning.In our daily lives, the bodies of both animals and humans are subjected to various forms of violence, some of which are severe enough to destroy the skin's continuity.A wound is a breakdown in the continuity of the skin. When the skin's continuity is disrupted, the body's interior organs are exposed.There's a risk of death in this case.There's a risk of death in this case. The skin's immediate response to a wound is the first step in the healing process, which begins automatically after the injury has been inflicted.It is possible to speed up this process in a variety of ways, including keeping the wound free of bacterial infection, moisture, and dirt.A number of antiseptic dressings are available for this purpose, and when applied topically,they help to speed up the healing process of wounds.They protect the wound from contamination by microorganisms and speed up the healing process.Among these are Aloe vera, honey, and turmeric, all of which have considerable wound healing capabilities.Turmeric, honey, and Aloe vera are all considered good for promoting wound healing.They are involved in the prevention of platelet aggregation, myocardial infarction, tumour formation, inflammatory cytokine release, oxidative stress, and metastasis.Several studies have demonstrated that they play a critical function in the promotion of wound healing. Their use for wound dressing has proven to be a successful method. The primary goal of this review is to summarise previous scientists' findings with authentic concluding verse for the use of Aloe vera,Turmeric and Honey that are safe, readily available, and less expensive.

[1]  M. Farahpour,et al.  Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[2]  I. Iglesias,et al.  Pharmacological Update Properties of Aloe Vera and its Major Active Constituents , 2020, Molecules.

[3]  X. Xia,et al.  Aloin Preconditioning Attenuates Hepatic Ischemia/Reperfusion Injury via Inhibiting TLR4/MyD88/NF-κB Signal Pathway In Vivo and In Vitro , 2019, Oxidative medicine and cellular longevity.

[4]  G. Jeong,et al.  Renal protective effects of aloin in a mouse model of sepsis. , 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[5]  M. Coimbra,et al.  Compositional Features and Bioactive Properties of Aloe vera Leaf (Fillet, Mucilage, and Rind) and Flower , 2019, Antioxidants.

[6]  B. Razavi,et al.  Aloe vera as an herbal medicine in the treatment of metabolic syndrome: A review , 2019, Phytotherapy research : PTR.

[7]  Amit Kumar Singh,et al.  Therapeutic potential of Aloe vera-A miracle gift of nature. , 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[8]  Yuliang Cheng,et al.  Extraction, Purification, Structural Characteristics, Biological Activities and Pharmacological Applications of Acemannan, a Polysaccharide from Aloe vera: A Review , 2019, Molecules.

[9]  M. T. Islam,et al.  Mutagenic, antioxidant and wound healing properties of Aloe vera. , 2018, Journal of ethnopharmacology.

[10]  A. Femenia,et al.  Compositional and Structural Features of the Main Bioactive Polysaccharides Present in the Aloe vera Plant. , 2018, Journal of AOAC International.

[11]  N. Jeyashoke,et al.  Identification of β-Sitosterol as in Vitro Anti-Inflammatory Constituent in Moringa oleifera. , 2018, Journal of agricultural and food chemistry.

[12]  Ruibing Wang,et al.  Biomedical applications of Aloe vera , 2018, Critical reviews in food science and nutrition.

[13]  Chairat Burusapat,et al.  Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review , 2018, Plastic and reconstructive surgery.

[14]  Xuan Luo,et al.  Aloin Suppresses Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Inhibiting the Activation of NF-κB , 2018, Molecules.

[15]  S. Nie,et al.  Polysaccharide from leaf skin of Aloe barbadensis Miller: Part I. Extraction, fractionation, physicochemical properties and structural characterization , 2017 .

[16]  Seon-Gil Do,et al.  Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo. , 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[17]  Long-Jian Li,et al.  Evaluation of efficacy of aloin in treating acute trauma in vitro and in vivo , 2017 .

[18]  M. B. Boroujeni,et al.  The effect of aloe vera on the expression of wound healing factors (TGFβ1 and bFGF) in mouse embryonic fibroblast cell: In vitro study. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[19]  M. Bordoloi,et al.  Aloe vera: A multipurpose industrial crop , 2016 .

[20]  A. Sahebkar,et al.  Therapeutic effects of Aloe spp. in traditional and modern medicine: A review. , 2016, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[21]  Hao Sun,et al.  A Comprehensive and System Review for the Pharmacological Mechanism of Action of Rhein, an Active Anthraquinone Ingredient , 2016, Front. Pharmacol..

[22]  A. Oryan,et al.  Topical Application of Aloe vera Accelerated Wound Healing, Modeling, and Remodeling: An Experimental Study , 2016, Annals of plastic surgery.

[23]  K. Gupta,et al.  Bilayer Cryogel Wound Dressing and Skin Regeneration Grafts for the Treatment of Acute Skin Wounds. , 2016, ACS applied materials & interfaces.

[24]  R. Hobson Vitamin E and wound healing: an evidence‐based review , 2016, International wound journal.

[25]  Lei Jiang,et al.  Aloe vera and Vitis vinifera improve wound healing in an in vivo rat burn wound model. , 2016, Molecular medicine reports.

[26]  S. Onteru,et al.  Hypoglycemic and Hypolipidemic Effects of Aloe vera Extract Preparations: A Review , 2016, Phytotherapy research : PTR.

[27]  Haidy A. Gad,et al.  A Systemic Review on Aloe arborescens Pharmacological Profile: Biological Activities and Pilot Clinical Trials , 2015, Phytotherapy research : PTR.

[28]  W. Tachaboonyakiat,et al.  Deacetylation affects the physical properties and bioactivity of acemannan, an extracted polysaccharide from Aloe vera. , 2015, Carbohydrate polymers.

[29]  W. Xing,et al.  Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. , 2015, Journal of dermatological science.

[30]  S. Abediankenari,et al.  The Review on Properties of Aloe Vera in Healing of Cutaneous Wounds , 2015, BioMed research international.

[31]  S. Gangemi,et al.  Review of Clinical Pharmacology of Aloe vera L. in the Treatment of Psoriasis , 2015, Phytotherapy research : PTR.

[32]  Yuchun Wang,et al.  Germacrone inhibits the proliferation of glioma cells by promoting apoptosis and inducing cell cycle arrest. , 2014, Molecular medicine reports.

[33]  A. Boligon,et al.  Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats. , 2014, Journal of photochemistry and photobiology. B, Biology.

[34]  A. Oryan,et al.  Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat. , 2014, International journal of biological macromolecules.

[35]  Y. Jeon,et al.  In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (Aloe barbadensis) gel. , 2014, Carbohydrate polymers.

[36]  S. Benkő,et al.  Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages. , 2013, Molecular immunology.

[37]  E. Crescenzi,et al.  A Biochemical and Cellular Approach to Explore the Antiproliferative and Prodifferentiative Activity of Aloe Arborescens Leaf Extract , 2013, Phytotherapy research : PTR.

[38]  D. C. Jain,et al.  Phytochemical investigation of ethyl acetate extract from Curcuma aromatica Salisb. rhizomes , 2013 .

[39]  Shamim Ahmad,et al.  Phytoconstituents from the rhizomes of Curcuma aromatica Salisb. , 2011 .

[40]  A. Khachemoune,et al.  Honey and Wound Healing , 2011, American journal of clinical dermatology.

[41]  A. Khachemoune,et al.  Vitamins and cutaneous wound healing. , 2011, Journal of wound care.

[42]  M. Baliga,et al.  Effect of topical honey on limitation of radiation-induced oral mucositis: an intervention study. , 2010, International journal of oral and maxillofacial surgery.

[43]  G. Gethin,et al.  Comparison of the antimicrobial activity of Ulmo honey from Chile and Manuka honey against methicillin-resistant Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. , 2010, BMC complementary and alternative medicine.

[44]  J. Janis,et al.  A Practical Guide to Wound Healing , 2010, Plastic and reconstructive surgery.

[45]  E. Rodríguez,et al.  Aloe vera as a Functional Ingredient in Foods , 2010 .

[46]  Mi-Kyung Sung,et al.  Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages , 2009, Bioscience, biotechnology, and biochemistry.

[47]  Josias H. Hamman,et al.  Composition and Applications of Aloe vera Leaf Gel , 2008, Molecules.

[48]  A. Moghadamnia,et al.  The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. , 2008, The journal of contemporary dental practice.

[49]  A. Simon,et al.  Medical Honey for Wound Care—Still the ‘Latest Resort’? , 2008, Evidence-based complementary and alternative medicine : eCAM.

[50]  A. Rodgers,et al.  Randomized clinical trial of honey‐impregnated dressings for venous leg ulcers , 2007, The British journal of surgery.

[51]  D. Carter,et al.  Honey has an antifungal effect against Candida species. , 2006, Medical mycology.

[52]  F. Beland,et al.  An Evaluation of the Biological and Toxicological Properties of Aloe Barbadensis (Miller), Aloe Vera , 2006, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

[53]  C. Mcintosh,et al.  Honey dressing versus paraffin tulle gras following toenail surgery. , 2006, Journal of wound care.

[54]  J. Wilkinson,et al.  Bactericidal activity of different honeys against pathogenic bacteria. , 2005, Archives of medical research.

[55]  R. Cooper,et al.  The antibacterial activity of honey against coagulase-negative staphylococci. , 2005, The Journal of antimicrobial chemotherapy.

[56]  S. Chauhan,et al.  Honey dressing in pediatric burns , 2005 .

[57]  B. M. Biswal,et al.  Topical application of honey in the management of radiation mucositis. A Preliminary study , 2003, Supportive Care in Cancer.

[58]  R. Cooper,et al.  The sensitivity to honey of Gram‐positive cocci of clinical significance isolated from wounds , 2002, Journal of applied microbiology.

[59]  R. Cooper,et al.  The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. , 2002, The Journal of burn care & rehabilitation.

[60]  M. Chung,et al.  Angiogenic activity of beta-sitosterol in the ischaemia/reperfusion-damaged brain of Mongolian gerbil. , 2002, Planta medica.

[61]  M. Chung,et al.  The wound‐healing effect of a glycoprotein fraction isolated from aloe vera , 2001, The British journal of dermatology.

[62]  K. Seers,et al.  Systematic review of the use of honey as a wound dressing , 2001, BMC complementary and alternative medicine.

[63]  A. Oryan,et al.  Effects of topical application of honey on cutaneous wound healing in rabbits. , 1998, Zentralblatt fur Veterinarmedizin. Reihe A.

[64]  M. Subrahmanyam Honey dressing versus boiled potato peel in the treatment of burns: a prospective randomized study. , 1996, Burns : journal of the International Society for Burn Injuries.

[65]  M. Subrahmanyam Honey-impregnated gauze versus amniotic membrane in the treatment of burns. , 1994, Burns : journal of the International Society for Burn Injuries.

[66]  P. Molan,et al.  A Survey of the Antibacterial Activity of Some New Zealand Honeys , 1991, The Journal of pharmacy and pharmacology.

[67]  M. Subrahmanyam Topical application of honey in treatment of burns , 1991, The British journal of surgery.

[68]  S E Efem,et al.  Clinical observations on the wound healing properties of honey , 1988, The British journal of surgery.

[69]  J. Yanai,et al.  Acceleration of wound healing by topical application of honey. An animal model. , 1983, American journal of surgery.

[70]  Sujata Sharma,et al.  Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel. , 2011, International journal of biological macromolecules.

[71]  Aly Saber Effect of honey versus intergel in intraperitoneal adhesion prevention and colonic anastomotic healing: a randomized controlled study in rats. , 2010, International journal of surgery.

[72]  M. Robson,et al.  Delayed wound closures based on bacterial counts , 1970, Journal of surgical oncology.