RNA polymerases as molecular motors

Chapter 1: Where it all Begins: An Overview of Promoter Recognition and Open Complex Formation Chapter 2: Opening the DNA at the Promoter The Energetic Challenge Chapter 3: Intrinsic In Vivo Modulators: Negative Supercoiling and the Constituents of the Bacterial Nucleoid Chapter 4: Transcription by RNA Polymerases: From Initiation to Elongation, Translocation and Strand Separation Chapter 5: Single-molecule FRET Analysis of the Path from Transcription Initiation to Elongation Chapter 6: Real-time Detection of DNA Unwinding by Escherichia coli RNAP: From Transcription Initiation to Termination Part II: Transcription Elongation and Termination, Interlude, The Engine and the Brake Chapter 7: Substrate Loading, Nucleotide Addition, and Translocation by RNA Polymerase Chapter 8: Regulation of RNA Polymerase through its Active Center Chapter 9: Kinetic Modeling of Transcription Elongation Chapter 10: Mechanics of Transcription Termination Conclusion: Past, Present, and Future of Single-molecule Studies of Transcription