Structural aspects of ion pumping by Ca 2+-ATPase of sarcoplasmic reticulum

Ca2+-ATPase of muscle sarcoplasmic reticulum (SR) is an ATP-powered Ca2+ pump that establishes >10 000-fold concentration gradient across the membrane for Ca2+ used for muscle contraction. Its crystal structures have been determined for seven different states that cover almost the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, in which a series of very large domain rearrangements takes place.

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