Fabrication of stimulus-responsive diatom biosilica microcapsules for antibiotic drug delivery.

In this report, we employed surface-initiated atom transfer radical polymerisation to graft thermo-responsive copolymers of oligo(ethylene glycol) methacrylates from the surface of diatom biosilica microcapsules. We demonstrate the application of the resulting composites for thermo-responsive drug delivery.

[1]  Jun Hu,et al.  Sorption properties of Th(IV) on the raw diatomite--effects of contact time, pH, ionic strength and temperature. , 2008, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[2]  T. Fukuda,et al.  Structure and properties of high-density polymer brushes prepared by surface-initiated living radical polymerization , 2006 .

[3]  J. Addai-Mensah,et al.  Silica microcapsules from diatoms as new carrier for delivery of therapeutics. , 2011, Nanomedicine.

[4]  Mei-Jia Yang,et al.  A Composite Thermo‐Responsive Membrane System for Improved Controlled‐Release , 2007 .

[5]  Chad A Mirkin,et al.  Control of nanoparticle assembly by using DNA-modified diatom templates. , 2004, Angewandte Chemie.

[6]  Robert Hernandez The use of systemic antibiotics in the treatment of chronic wounds , 2006, Dermatologic therapy.

[7]  P. Arcari,et al.  Diatomite silica nanoparticles for drug delivery , 2014, Nanoscale Research Letters.

[8]  Jianlin Shi,et al.  Hollow‐Structured Mesoporous Materials: Chemical Synthesis, Functionalization and Applications , 2014, Advanced materials.

[9]  Martin A. Cole,et al.  Stimulus-responsiveness and drug release from porous silicon films ATRP-grafted with poly(N-isopropylacrylamide). , 2011, Langmuir : the ACS journal of surfaces and colloids.

[10]  S. Dowd,et al.  A rapid molecular method for characterising bacterial bioburden in chronic wounds. , 2008, Journal of wound care.

[11]  Ulrich S. Schubert,et al.  Libraries of methacrylic acid and oligo(ethylene glycol) methacrylate copolymers with LCST behavior , 2008 .

[12]  Christopher S. Gaddis,et al.  Freestanding microscale 3D polymeric structures with biologically-derived shapes and nanoscale features , 2004 .

[13]  Yufang Zhu,et al.  Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core-shell structure. , 2005, Angewandte Chemie.

[14]  Jean-François Lutz,et al.  Point by point comparison of two thermosensitive polymers exhibiting a similar LCST: is the age of poly(NIPAM) over? , 2006, Journal of the American Chemical Society.

[15]  J. Ferreira,et al.  Development of porous HAp and β-TCP scaffolds by starch consolidation with foaming method and drug-chitosan bilayered scaffold based drug delivery system , 2010, Journal of materials science. Materials in medicine.

[16]  M. Guardia,et al.  Applications of diatoms and silica nanotechnology in biosensing, drug and gene delivery, and formation of complex metal nanostructures , 2011 .

[17]  J. Lutz,et al.  About the Phase Transitions in Aqueous Solutions of Thermoresponsive Copolymers and Hydrogels Based on 2-(2-methoxyethoxy)ethyl Methacrylate and Oligo(ethylene glycol) Methacrylate , 2007 .

[18]  Dusan Losic,et al.  Diatomaceous Lessons in Nanotechnology and Advanced Materials , 2009 .

[19]  Mahaveer D. Kurkuri,et al.  Graphene oxide decorated diatom silica particles as new nano-hybrids: towards smart natural drug microcarriers. , 2013, Journal of materials chemistry. B.

[20]  P. Arcari,et al.  Diatomite biosilica nanocarriers for siRNA transport inside cancer cells. , 2014, Biochimica et biophysica acta.

[21]  René M. Rossi,et al.  Synthesis of poly(oligo(ethylene glycol)methacrylate)-functionalized membranes for thermally controlled drug delivery , 2013 .

[22]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[23]  Tong Cai,et al.  Thermoresponsive oligo(ethylene glycol)-methacrylate- based polymers and microgels , 2010 .

[24]  Mahaveer D. Kurkuri,et al.  Thermosensitive copolymer coatings with enhanced wettability switching. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[25]  S. Sukhishvili,et al.  Self-defensive layer-by-layer films with bacteria-triggered antibiotic release. , 2014, ACS nano.

[26]  Kevin Barraclough,et al.  I and i , 2001, BMJ : British Medical Journal.

[27]  Cheng-Fu Yang,et al.  Prepare dispersed CIS nano-scale particles and spray coating CIS absorber layers using nano-scale precursors , 2014, Nanoscale Research Letters.

[28]  Mahaveer D. Kurkuri,et al.  Tuning drug loading and release properties of diatom silica microparticles by surface modifications. , 2013, International journal of pharmaceutics.

[29]  J. Lutz,et al.  Polymerization of oligo(ethylene glycol) (meth)acrylates: Toward new generations of smart biocompatible materials , 2008 .

[30]  D. Collard,et al.  Controlling Cell Adhesion to Titanium: Functionalization of Poly[oligo(ethylene glycol)methacrylate] Brushes with Cell‐Adhesive Peptides , 2007 .

[31]  J. Addai-Mensah,et al.  Synthesis of self-supporting gold microstructures with three-dimensional morphologies by direct replication of diatom templates. , 2010, Langmuir : the ACS journal of surfaces and colloids.

[32]  M. P. Montanari,et al.  In Vitro Antibacterial Activities of AF 3013, the Active Metabolite of Prulifloxacin, against Nosocomial and Community Italian Isolates , 2001, Antimicrobial Agents and Chemotherapy.

[33]  Richard Gordon,et al.  The Glass Menagerie: diatoms for novel applications in nanotechnology. , 2009, Trends in biotechnology.

[34]  N. Voelcker,et al.  Combination of iCVD and porous silicon for the development of a controlled drug delivery system. , 2012, ACS applied materials & interfaces.

[35]  J. Addai-Mensah,et al.  Surface-functionalized diatom microcapsules for drug delivery of water-insoluble drugs , 2013, Journal of biomaterials applications.

[36]  J. Andrews,et al.  Determination of minimum inhibitory concentrations. , 2001, The Journal of antimicrobial chemotherapy.