Correlation between GRIK2 rs6922753, rs2227283 polymorphism and aggressive behaviors with Bipolar Mania in the Chinese Han population

Animal studies have shown that glutamate receptor ionotropic kainate 2 (GRIK2) gene knockout mice are more impulsive and aggressive. This study aims to verify whether the rs6922753 and rs2227283 polymorphisms of the GRIK2 gene are associated with both aggressive behavior and bipolar mania in the Chinese Han population.

[1]  Bong-June Yoon,et al.  CRMP2 mediates GSK3β actions in the striatum on regulating neuronal structure and mania-like behavior. , 2019, Journal of affective disorders.

[2]  M. Frye,et al.  Novel Complex Interactions between Mitochondrial and Nuclear DNA in Schizophrenia and Bipolar Disorder , 2019, Molecular Neuropsychiatry.

[3]  J. E. Huettner,et al.  Cadmium opens GluK2 kainate receptors with cysteine substitutions at the M3 helix bundle crossing , 2018, The Journal of general physiology.

[4]  Yan-You Huang,et al.  Kainate receptor mediated presynaptic LTP in agranular insular cortex contributes to fear and anxiety in mice , 2018, Neuropharmacology.

[5]  Shaohong Zou,et al.  An association analysis between polymorphism of glutamate receptor 6 gene and impulsively aggressive behavior in patients with bipolar disorder , 2017 .

[6]  A. Carvalho,et al.  Genetic Studies on the Tripartite Glutamate Synapse in the Pathophysiology and Therapeutics of Mood Disorders , 2017, Neuropsychopharmacology.

[7]  J. Kastrup,et al.  Lessons from crystal structures of kainate receptors , 2017, Neuropharmacology.

[8]  S. Ferguson,et al.  Metabotropic glutamate receptors and neurodegenerative diseases. , 2017, Pharmacological research.

[9]  S. Yimer,et al.  Magnitude and associated factors of aggressive behaviour among patients with bipolar disorder at Amanual Mental Specialized Hospital, outpatient department, Addis Ababa, Ethiopia: cross-sectional study , 2016, BMC Psychiatry.

[10]  T. Vos,et al.  The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013 , 2016, Bipolar disorders.

[11]  A. Reif,et al.  Aggression in non‐human vertebrates: Genetic mechanisms and molecular pathways , 2016, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[12]  P. Sham,et al.  Longitudinal heritability of childhood aggression , 2016, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[13]  Wim E Crusio,et al.  Comparative mRNA analysis of behavioral and genetic mouse models of aggression , 2016, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[14]  S. Faraone,et al.  Genetics of aggressive behavior: An overview , 2016, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[15]  R. Maldonado,et al.  The endocannabinoid system in guarding against fear, anxiety and stress , 2015, Nature Reviews Neuroscience.

[16]  J. E. Huettner,et al.  Glutamate receptor pores , 2015, The Journal of physiology.

[17]  K. Hashimoto,et al.  Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: a study of two independent cohorts. , 2014, Journal of affective disorders.

[18]  M. Wajner,et al.  Increased Glutamate Receptor and Transporter Expression in the Cerebral Cortex and Striatum of Gcdh -/- Mice: Possible Implications for the Neuropathology of Glutaric Acidemia Type I , 2014, PloS one.

[19]  Zou Shao-hon.  Association between polymorphism of GluR6 gene and domestic violence in patients with alcohol dependence of Han people in Xinjiang , 2014 .

[20]  A. Takahashi,et al.  Neurogenetics of aggressive behavior: studies in rodents. , 2014, Current topics in behavioral neurosciences.

[21]  C. Barr,et al.  Neurogenetics of aggressive behavior: studies in primates. , 2014, Current topics in behavioral neurosciences.

[22]  Shyh-Jen Wang,et al.  Aggression in bipolar II disorder and its relation to the serotonin transporter. , 2013, Journal of affective disorders.

[23]  M. Leboyer,et al.  Biomarkers in bipolar disorder: A positional paper from the International Society for Bipolar Disorders Biomarkers Task Force , 2013, The Australian and New Zealand journal of psychiatry.

[24]  D. Kupfer,et al.  Is bipolar disorder specifically associated with aggression? , 2012, Bipolar disorders.

[25]  S. Comai,et al.  The Psychopharmacology of Aggressive Behavior: A Translational Approach Part 2 Clinical Studies Using Atypical Antipsychotics, Anticonvulsants, and Lithium , 2012, Journal of clinical psychopharmacology.

[26]  M. Leboyer,et al.  Genetics of circadian rhythms and mood spectrum disorders , 2011, European Neuropsychopharmacology.

[27]  R. Dingledine,et al.  Glutamate Receptor Ion Channels: Structure, Regulation, and Function , 2010, Pharmacological Reviews.

[28]  Graham L. Collingridge,et al.  A nomenclature for ligand-gated ion channels , 2009, Neuropharmacology.

[29]  D. Luckenbaugh,et al.  Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania , 2008, Molecular Psychiatry.

[30]  Tadafumi Kato,et al.  Animal models of bipolar disorder , 2007, Neuroscience & Biobehavioral Reviews.

[31]  J. Meador-Woodruff,et al.  Abnormal Glutamate Receptor Expression in the Medial Temporal Lobe in Schizophrenia and Mood Disorders , 2007, Neuropsychopharmacology.

[32]  Robert Ho,et al.  Handbook of Univariate and Multivariate Data Analysis and Interpretation with SPSS , 2006 .

[33]  方贻儒,et al.  Association study between ionotropic glutamate receptor 6 (GIuR6) gene polymorphisms and schizophrenia, aggressive behavior , 2006 .

[34]  J Melke,et al.  Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia , 2004, Neuroreport.

[35]  S. Maxson,et al.  Conceptual and methodological issues in the genetics of mouse agonistic behavior , 2003, Hormones and Behavior.

[36]  K. Miczek,et al.  Aggressive behavioral phenotypes in mice , 2001, Behavioural Brain Research.

[37]  A. Barbon,et al.  Genomic organization of the human GRIK2 gene and evidence for multiple splicing variants. , 2001, Gene.