First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models
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David J Brayden | D. Mash | O. Hardiman | S. O’Mara | K. Tipton | C. Walsh | A. Vajda | M. Elamin | J. Callanan | O. Gobbo | S. Ryan | J. A. Kelly | G. Scalabrino | L. Corte | M. Campbell | C. Stefanini | K. O’boyle | N. Cole | N. Boyle | J. Hunter | G. R. Slator | C. H. Williams | Margaret M. Goggin | M. Colivicchi
[1] D. Morris,et al. Delineating the genetic heterogeneity of ALS using targeted high-throughput sequencing , 2013, Journal of Medical Genetics.
[2] B. Raaka,et al. Thyrotropin-Releasing Hormone Receptor Type 1 (TRH-R1), not TRH-R2, Primarily Mediates Taltirelin Actions in the CNS of Mice , 2013, Neuropsychopharmacology.
[3] L. Mucke,et al. Neurotoxicity of amyloid β-protein: synaptic and network dysfunction. , 2012, Cold Spring Harbor perspectives in medicine.
[4] Y. Michotte,et al. Ghrelin: An emerging new anticonvulsant neuropeptide , 2012, Epilepsia.
[5] L. Mucke,et al. Alzheimer Mechanisms and Therapeutic Strategies , 2012, Cell.
[6] J. Hardy,et al. Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72. , 2012, Brain : a journal of neurology.
[7] T. Hortobágyi,et al. p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS , 2011, Acta Neuropathologica.
[8] M. Iigo,et al. Molecular cloning, molecular evolution and gene expression of cDNAs encoding thyrotropin-releasing hormone receptor subtypes in a teleost, the sockeye salmon (Oncorhynchus nerka). , 2011, General and comparative endocrinology.
[9] W. Geldenhuys,et al. The emergence of designed multiple ligands for neurodegenerative disorders , 2011, Progress in Neurobiology.
[10] L. Bianchi,et al. Highly reactive oxygen species: detection, formation, and possible functions , 2011, Cellular and Molecular Life Sciences.
[11] M. Beal,et al. Neuroprotective effects of creatine , 2011, Amino Acids.
[12] S. Petri,et al. Significance of behavioural tests in a transgenic mouse model of amyotrophic lateral sclerosis (ALS) , 2010, Behavioural Brain Research.
[13] G. Miller. Is pharma running out of brainy ideas? , 2010, Science.
[14] Albert C. Ludolph,et al. Guidelines for preclinical animal research in ALS/MND: A consensus meeting , 2010, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.
[15] H. Geerts. Of Mice and Men , 2009, CNS drugs.
[16] L. Jaworska-Feil,et al. Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents , 2009, Neuropeptides.
[17] W. Pardridge. Alzheimer's disease drug development and the problem of the blood-brain barrier , 2009, Alzheimer's & Dementia.
[18] Z. Chi,et al. Alterations of NR2B and PSD-95 expression in hippocampus of kainic acid-exposed rats with behavioural deficits , 2009, Behavioural Brain Research.
[19] S. Perrin,et al. No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS , 2009, PloS one.
[20] M. Williams,et al. Challenges in the Search for Drugs to Treat Central Nervous System Disorders , 2009, Journal of Pharmacology and Experimental Therapeutics.
[21] David J Brayden,et al. Conjugation of salmon calcitonin to a combed-shaped end functionalized poly(poly(ethylene glycol) methyl ether methacrylate) yields a bioactive stable conjugate. , 2009, Journal of controlled release : official journal of the Controlled Release Society.
[22] L. Mucke,et al. Epilepsy and cognitive impairments in Alzheimer disease. , 2009, Archives of neurology.
[23] S. Przedborski,et al. Oxidative Stress in Parkinson's Disease , 2008, Annals of the New York Academy of Sciences.
[24] B. Kalmar,et al. Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1G93A mouse model of ALS , 2008, Journal of neurochemistry.
[25] C. Ballini,et al. Validation of a robust and sensitive method for detecting hydroxyl radical formation together with evoked neurotransmitter release in brain microdialysis , 2008, Journal of neurochemistry.
[26] P. M. Hinkle,et al. Corrigendum to “A novel TRH analog, Glp–Asn–Pro–d-Tyr–d-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2” [Neurosci. Lett. 431 (2007) 26–30] , 2008, Neuroscience Letters.
[27] P. M. Hinkle,et al. A novel TRH analog, Glp–Asn–Pro–d-Tyr–d-TrpNH2, binds to [3H][3-Me-His2]TRH-labelled sites in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRHR1 or TRHR2 , 2008, Neuroscience Letters.
[28] Maurizio Recanatini,et al. Multi-target-directed ligands to combat neurodegenerative diseases. , 2008, Journal of medicinal chemistry.
[29] J. E. Kranz,et al. Design, power, and interpretation of studies in the standard murine model of ALS , 2008, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.
[30] David E. Gloriam,et al. The G protein-coupled receptor subset of the rat genome , 2007, BMC Genomics.
[31] M. Pangalos,et al. Drug development for CNS disorders: strategies for balancing risk and reducing attrition , 2007, Nature Reviews Drug Discovery.
[32] K. Tipton,et al. Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone , 2007, Neuropharmacology.
[33] Xianzeng Liu,et al. Impaired single cell firing and long‐term potentiation parallels memory impairment following recurrent seizures , 2007, The European journal of neuroscience.
[34] V. Meininger,et al. Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: Report on the 142nd ENMC international workshop , 2007, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.
[35] L. Mucke,et al. A network dysfunction perspective on neurodegenerative diseases , 2006, Nature.
[36] C. Vorhees,et al. Morris water maze: procedures for assessing spatial and related forms of learning and memory , 2006, Nature Protocols.
[37] A. Faden,et al. Neuroprotective effects of novel small peptides in vitro and after brain injury , 2005, Neuropharmacology.
[38] K. Tipton,et al. Structure-activity studies with high-affinity inhibitors of pyroglutamyl-peptidase II. , 2005, The Biochemical journal.
[39] S. O’Mara,et al. Combining exercise and cyclooxygenase-2 inhibition does not ameliorate learning deficits after brain insult, despite an increase in BDNF levels , 2005, Brain Research.
[40] W. Pardridge. Molecular biology of the blood-brain barrier , 2005, Methods in molecular medicine.
[41] H. Vaudry,et al. Distribution of the mRNAs encoding the thyrotropin‐releasing hormone (TRH) precursor and three TRH receptors in the brain and pituitary of Xenopus laevis: Effect of background color adaptation on TRH and TRH receptor gene expression , 2004, The Journal of comparative neurology.
[42] I. Kola,et al. Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.
[43] A. Prange,et al. The Thyrotropin-Releasing Hormone (TRH) Hypothesis of Homeostatic Regulation: Implications for TRH-Based Therapeutics , 2003, Journal of Pharmacology and Experimental Therapeutics.
[44] M. Gershengorn,et al. Pharmacological studies of thyrotropin-releasing hormone (TRH) receptors from Xenopus laevis: is xTRHR3 a TRH receptor? , 2003, Endocrinology.
[45] M. Gershengorn,et al. Thyrotropin-releasing hormone receptors -- similarities and differences. , 2003, Journal of molecular endocrinology.
[46] Susan R. George,et al. G-Protein-coupled receptor oligomerization and its potential for drug discovery , 2002, Nature Reviews Drug Discovery.
[47] P. Lory,et al. Characterization and functional expression of cDNAs encoding thyrotropin-releasing hormone receptor from Xenopus laevis. , 2002, European journal of biochemistry.
[48] J. A. Kelly,et al. Pharmacologically distinct binding sites in rat brain for [3H]thyrotropin-releasing hormone (TRH) and [3H][3-methyl-histidine(2)]TRH. , 2002, Biochemical pharmacology.
[49] E J Park,et al. Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. , 2001, The journal of peptide research : official journal of the American Peptide Society.
[50] R. D'Hooge,et al. Applications of the Morris water maze in the study of learning and memory , 2001, Brain Research Reviews.
[51] D. Middlemiss,et al. Characterization of [125I]‐SB‐258585 binding to human recombinant and native 5‐HT6 receptors in rat, pig and human brain tissue , 2000 .
[52] K. Tipton,et al. Kinetic Investigation of the Specificity of Porcine Brain Thyrotropin-releasing Hormone-degrading Ectoenzyme for Thyrotropin-releasing Hormone-like Peptides* , 2000, The Journal of Biological Chemistry.
[53] Ole A. Andreassen,et al. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis , 1999, Nature Medicine.
[54] K Payza,et al. Cloning and Characterization of a cDNA Encoding a Novel Subtype of Rat Thyrotropin-releasing Hormone Receptor* , 1998, The Journal of Biological Chemistry.
[55] H. Iwaasa,et al. Cloning and characterization of a new subtype of thyrotropin-releasing hormone receptors. , 1998, Biochemical and biophysical research communications.
[56] K. Hashimoto,et al. A novel transcript for the thyrotropin-releasing hormone receptor in human pituitary and pituitary tumors. , 1997, The Journal of clinical endocrinology and metabolism.
[57] M. Gurney,et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.
[58] G. Holmes,et al. Neuroprotective Effect of Felbamate After Kainic Acid‐Induced Status Epilepticus , 1993, Epilepsia.
[59] W. Pardridge,et al. Capillary Depletion Method for Quantification of Blood–Brain Barrier Transport of Circulating Peptides and Plasma Proteins , 1990, Journal of neurochemistry.
[60] E. Griffiths. Clinical applications of thyrotrophin-releasing hormone. , 1987, Clinical science.
[61] T. Rainbow,et al. Autoradiographic localization of thyr tropin releasing hormone receptors in human brain , 1986, Neurology.
[62] C. Parker,et al. Thyrotropin releasing hormone (TRH) binding sites in the adult human brain: Localization and characterization , 1984, Peptides.
[63] G. Boschi,et al. Antinociceptive properties of thyrotropin releasing hormone in mice: comparison with morphine , 1983, British journal of pharmacology.
[64] J. Hershman. Clinical Application of Thyrotropin-Releasing Hormone , 1974 .
[65] A. McKee,et al. The spectrum of disease in chronic traumatic encephalopathy. , 2013, Brain : a journal of neurology.
[66] Stuart Maudsley,et al. The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases. , 2013, American journal of Alzheimer's disease.
[67] B. Stoica,et al. Multifunctional drug treatment in neurotrauma , 2011, Neurotherapeutics.
[68] M. Khrestchatisky,et al. Synthetic therapeutic peptides: science and market. , 2010, Drug discovery today.
[69] Thomas Steckler,et al. Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models , 2009, Neuropsychopharmacology.
[70] A. Prange,et al. The thyrotropin-releasing hormone (TRH)-immune system homeostatic hypothesis. , 2009, Pharmacology & therapeutics.
[71] Mario Delgado,et al. Regulation of immune tolerance by anti-inflammatory neuropeptides , 2007, Nature Reviews Immunology.
[72] M. Kubek,et al. Thyrotropin-releasing hormone in the treatment of intractable epilepsy. , 2002, Pediatric neurology.
[73] B. O'dowd,et al. TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1. , 2000, Molecular endocrinology.
[74] J. A. Kelly. Thyrotropin-releasing hormone: basis and potential for its therapeutic use. , 1995, Essays in biochemistry.