RNA processing as an alternative route to attack glioblastoma
暂无分享,去创建一个
[1] Fengqin Wang,et al. Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy , 2017, Neuroscience.
[2] Jay-Jiguang Zhu,et al. Metformin treatment reduces temozolomide resistance of glioblastoma cells , 2016, Oncotarget.
[3] S. Agarwal,et al. Functional genomics analyses of RNA-binding proteins reveal the splicing regulator SNRPB as an oncogenic candidate in glioblastoma , 2016, Genome Biology.
[4] Robin T. Varghese,et al. Survival kinase genes present prognostic significance in glioblastoma , 2016, Oncotarget.
[5] Mihoko Kai. Roles of RNA-Binding Proteins in DNA Damage Response , 2016, International journal of molecular sciences.
[6] E. Chiocca,et al. Therapeutic potential of targeting microRNA‐10b in established intracranial glioblastoma: first steps toward the clinic , 2016, EMBO molecular medicine.
[7] S. Roman-Roman,et al. Cancer-associated SF3B1 mutations affect alternative splicing by promoting alternative branchpoint usage , 2016, Nature Communications.
[8] C. Vogel,et al. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect , 2016, RNA biology.
[9] M. Warmuth,et al. Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point. , 2015, Cell reports.
[10] S. Nelson,et al. Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients , 2015, PloS one.
[11] K. Gruden,et al. Heterogeneous glioblastoma cell cross-talk promotes phenotype alterations and enhanced drug resistance , 2015, Oncotarget.
[12] S. Marie,et al. Isolation and characterization of novel RECK tumor suppressor gene splice variants , 2015, Oncotarget.
[13] Sarah J. Kurley,et al. The spliceosome is a therapeutic vulnerability in MYC-driven cancer , 2015, Nature.
[14] Denise M. Coley,et al. The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons , 2015, Molecular and Cellular Neuroscience.
[15] Jong Ho Park,et al. Deleterious c-Cbl Exon Skipping Contributes to Human Glioma12 , 2015, Neoplasia.
[16] E. Levanon,et al. Identification of recurrent regulated alternative splicing events across human solid tumors , 2015, Nucleic acids research.
[17] Henry W. Long,et al. CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer. , 2015, Cancer research.
[18] G. Tedeschi,et al. Suggestive evidence on the involvement of polypyrimidine-tract binding protein in regulating alternative splicing of MAP/microtubule affinity-regulating kinase 4 in glioma. , 2015, Cancer letters.
[19] J. Phillips,et al. Proportional Upregulation of CD97 Isoforms in Glioblastoma and Glioblastoma-Derived Brain Tumor Initiating Cells , 2015, PloS one.
[20] Shawn M. Gomez,et al. Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors , 2015, Oncotarget.
[21] H. Ellis,et al. Current Therapeutic Advances Targeting EGFR and EGFRvIII in Glioblastoma , 2015, Front. Oncol..
[22] Caterina Marchiò,et al. SF3B1 mutations constitute a novel therapeutic target in breast cancer , 2014, The Journal of pathology.
[23] Sandeep Mittal,et al. Targeting adaptive glioblastoma: an overview of proliferation and invasion. , 2014, Neuro-oncology.
[24] P. Rogan,et al. Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer , 2014, Scientific Reports.
[25] H. Hamada,et al. RBM14 prevents assembly of centriolar protein complexes and maintains mitotic spindle integrity , 2014, The EMBO journal.
[26] F. Yu,et al. Identification of differential splicing genes in gliomas using exon expression profiling , 2014, Molecular medicine reports.
[27] C. Sander,et al. Genome-wide analysis of non-coding regulatory mutations in cancer , 2014, Nature Genetics.
[28] D. Scholtens,et al. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. , 2014, The Journal of clinical investigation.
[29] G. Mezey,et al. Prognosis in human glioblastoma based on expression of ligand growth hormone-releasing hormone, pituitary-type growth hormone-releasing hormone receptor, its splicing variant receptors, EGF receptor and PTEN genes , 2014, Journal of Cancer Research and Clinical Oncology.
[30] M. Yaylaoglu,et al. An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth , 2014, Genes & development.
[31] Wei Li,et al. CFIm25 links Alternative Polyadenylation to Glioblastoma Tumor Suppression , 2014, Nature.
[32] Mihoko Kai,et al. RNA binding protein RBM14 promotes radio-resistance in glioblastoma by regulating DNA repair and cell differentiation , 2014, Oncotarget.
[33] Chandra Sekhar Pedamallu,et al. A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events , 2014, PloS one.
[34] S. Janga,et al. Dissecting the expression landscape of RNA-binding proteins in human cancers , 2014, Genome Biology.
[35] P. Taneja,et al. AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors , 2014, Journal of oncology.
[36] W. T. Beck,et al. Involvement of polypyrimidine tract-binding protein (PTBP1) in maintaining breast cancer cell growth and malignant properties , 2014, Oncogenesis.
[37] Steven J. M. Jones,et al. A Pan-Cancer Analysis of Alternative Splicing Events Reveals Novel Tumor-Associated Splice Variants of Matriptase , 2014, Cancer informatics.
[38] D. Haussler,et al. The Somatic Genomic Landscape of Glioblastoma , 2013, Cell.
[39] Vishal N. Patel,et al. Network Signatures of Survival in Glioblastoma Multiforme , 2013, PLoS Comput. Biol..
[40] Yan-wei Liu,et al. Whole‐Genome mRNA Expression Profiling Identifies Functional and Prognostic Signatures in Patients with Mesenchymal Glioblastoma Multiforme , 2013, CNS neuroscience & therapeutics.
[41] F. J. Ramos,et al. Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors , 2013, Clinical Cancer Research.
[42] Jen-Yang Tang,et al. Modulating roles of amiloride in irradiation-induced antiproliferative effects in glioblastoma multiforme cells involving Akt phosphorylation and the alternative splicing of apoptotic genes. , 2013, DNA and cell biology.
[43] Pablo R. Freire,et al. Identification of prognostic gene signatures of glioblastoma: a study based on TCGA data analysis. , 2013, Neuro-oncology.
[44] Douglas L Black,et al. EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. , 2013, Cell metabolism.
[45] Emily J. Girard,et al. Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A. , 2013, Genes & development.
[46] B. Lin,et al. Alternative polyadenylation in glioblastoma multiforme and changes in predicted RNA binding protein profiles. , 2013, Omics : a journal of integrative biology.
[47] V. P. Collins,et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics , 2013, Proceedings of the National Academy of Sciences.
[48] L. C. Hinske,et al. In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing , 2013, Acta Neuropathologica.
[49] M. Cazzola,et al. Biologic and clinical significance of somatic mutations of SF3B1 in myeloid and lymphoid neoplasms. , 2013, Blood.
[50] Ahmed Sadeque,et al. Identification and characterization of alternative exon usage linked glioblastoma multiforme survival , 2012, BMC Medical Genomics.
[51] R. Krahe,et al. PTBP1‐dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis , 2012, Molecular carcinogenesis.
[52] Charles Y. Lin,et al. Transcriptional Amplification in Tumor Cells with Elevated c-Myc , 2012, Cell.
[53] M. Pajares,et al. Identification of Novel Deregulated RNA Metabolism-Related Genes in Non-Small Cell Lung Cancer , 2012, PloS one.
[54] Richard J Jackson,et al. Defining the roles and interactions of PTB. , 2012, Biochemical Society transactions.
[55] F. Murad,et al. Hydrogen Peroxide Alters Splicing of Soluble Guanylyl Cyclase and Selectively Modulates Expression of Splicing Regulators in Human Cancer Cells , 2012, PloS one.
[56] Rui F. Oliveira,et al. Face Your Fears: Cleaning Gobies Inspect Predators despite Being Stressed by Them , 2012, PloS one.
[57] M. Gorospe,et al. The Oncogenic RNA-Binding Protein Musashi1 Is Regulated by HuR via mRNA Translation and Stability in Glioblastoma Cells , 2012, Molecular Cancer Research.
[58] C. Brennan,et al. Splicing factor hnRNPH drives an oncogenic splicing switch in gliomas , 2011, The EMBO journal.
[59] Jianhua Ruan,et al. Genomic Analyses of the RNA-binding Protein Hu Antigen R (HuR) Identify a Complex Network of Target Genes and Novel Characteristics of Its Binding Sites* , 2011, The Journal of Biological Chemistry.
[60] N. Rajewsky,et al. Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. , 2011, Molecular cell.
[61] S. Srikantan,et al. UneCLIPsing HuR nuclear function. , 2011, Molecular cell.
[62] Uwe Ohler,et al. Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. , 2011, Molecular cell.
[63] Luigi Coppola,et al. Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma. , 2011, Cancer research.
[64] P. Potter,et al. Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. , 2011, ACS chemical biology.
[65] N. Filippova,et al. The RNA-Binding Protein HuR Promotes Glioma Growth and Treatment Resistance , 2011, Molecular Cancer Research.
[66] Kotb Abdelmohsen,et al. Posttranscriptional regulation of cancer traits by HuR , 2010, Wiley interdisciplinary reviews. RNA.
[67] S. Friedman,et al. Increased expression of the oncogenic KLF6-SV1 transcript in human glioblastoma , 2010, Clinical chemistry and laboratory medicine.
[68] C. Vogel,et al. A comprehensive in silico expression analysis of RNA binding proteins in normal and tumor tissue; identification of potential players in tumor formation , 2009, RNA biology.
[69] F. Ali-Osman,et al. A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion. , 2009, Cancer research.
[70] C. Mayr,et al. Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells , 2009, Cell.
[71] J. Martignetti,et al. The role of KLF6 and its splice variants in cancer therapy. , 2009, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[72] T. Waldman,et al. Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme. , 2008, Cancer research.
[73] R. Schiff,et al. Dual roles for coactivator activator and its counterbalancing isoform coactivator modulator in human kidney cell tumorigenesis. , 2008, Cancer research.
[74] K. Baggerly,et al. Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays , 2008, BMC Genomics.
[75] W. Sly,et al. Identification of an alternatively spliced isoform of carbonic anhydrase XII in diffusely infiltrating astrocytic gliomas. , 2008, Neuro-oncology.
[76] S. Friedman,et al. Functional inactivation of the KLF6 tumor suppressor gene by loss of heterozygosity and increased alternative splicing in glioblastoma , 2007, International journal of cancer.
[77] J. Coon,et al. Knockdown of polypyrimidine tract-binding protein suppresses ovarian tumor cell growth and invasiveness in vitro , 2007, Oncogene.
[78] D. Tuan,et al. Gene amplification and associated loss of 5′ regulatory sequences of CoAA in human cancers , 2007, Oncogene.
[79] N. Sharpless,et al. The Regulation of INK4/ARF in Cancer and Aging , 2006, Cell.
[80] U. Fischer,et al. Vitamin D3 Metabolism in Human Glioblastoma Multiforme: Functionality of CYP27B1 Splice Variants, Metabolism of Calcidiol, and Effect of Calcitriol , 2005, Clinical Cancer Research.
[81] J. Schvartzman,et al. Protein kinase clk/STY is differentially regulated during erythroleukemia cell differentiation: a bias toward the skipped splice variant characterizes postcommitment stages , 2005, Cell Research.
[82] T. Yamori,et al. Pladienolides, New Substances from Culture of Streptomyces platensis Mer-11107. Part 3. In vitro and in vivo Antitumor Activities. , 2004 .
[83] H. Kawami,et al. Identification of an Alternatively Spliced RNA for the Ras Suppressor RSU-1 in Human Gliomas , 2002, Journal of Neuro-Oncology.
[84] Bert W O'Malley,et al. Coordinate Regulation of Transcription and Splicing by Steroid Receptor Coregulators , 2002, Science.
[85] J. Schramm,et al. Alternative splicing of the p15 cdk inhibitor in glioblastoma multiforme , 2001, Acta Neuropathologica.
[86] G. Fuller,et al. Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors. , 2000, Cancer research.
[87] W. Jin,et al. Glioblastoma cell-specific expression of fibroblast growth factor receptor-1beta requires an intronic repressor of RNA splicing. , 1999, Cancer research.
[88] Kotb Abdelmohsen,et al. Posttranslational control of HuR function , 2017, Wiley interdisciplinary reviews. RNA.
[89] R. Verhaak,et al. GlioVis data portal for visualization and analysis of brain tumor expression datasets. , 2017, Neuro-oncology.
[90] Gene W. Yeo. RNA Processing Disease and Genome-wide Probing , 2016 .
[91] J. Schramm,et al. TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas. , 2015, Neuro-oncology.
[92] P. LoRusso,et al. A phase I, open-label, single-arm, dose-escalation study of E7107, a precursor messenger ribonucleic acid (pre-mRNA) splicesome inhibitor administered intravenously on days 1 and 8 every 21 days to patients with solid tumors , 2013, Investigational New Drugs.
[93] Emily J. Girard,et al. Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF 5 A , 2013 .
[94] Yuan Qi,et al. Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA , IDH 1 , EGFR , and NF 1 Citation Verhaak , 2010 .
[95] Brad T. Sherman,et al. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources , 2008, Nature Protocols.
[96] Xiuli Jiang,et al. Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. , 2007, Cancer research.
[97] G. Fuller,et al. Expression of the splicing regulator polypyrimidine tract-binding protein in normal and neoplastic brain. , 2004, Neuro-oncology.
[98] Teruyoshi Hishiki,et al. BodyMap: a human and mouse gene expression database , 2000, Nucleic Acids Res..