Imaging Techniques for Clinical Burn Assessment with a Focus on Multispectral Imaging.

Significance: Burn assessments, including extent and severity, are some of the most critical diagnoses in burn care, and many recently developed imaging techniques may have the potential to improve the accuracy of these evaluations. Recent Advances: Optical devices, telemedicine, and high-frequency ultrasound are among the highlights in recent burn imaging advancements. We present another promising technology, multispectral imaging (MSI), which also has the potential to impact current medical practice in burn care, among a variety of other specialties. Critical Issues: At this time, it is still a matter of debate as to why there is no consensus on the use of technology to assist burn assessments in the United States. Fortunately, the availability of techniques does not appear to be a limitation. However, the selection of appropriate imaging technology to augment the provision of burn care can be difficult for clinicians to navigate. There are many technologies available, but a comprehensive review summarizing the tissue characteristics measured by each technology in light of aiding clinicians in selecting the proper device is missing. This would be especially valuable for the nonburn specialists who encounter burn injuries. Future Directions: The questions of when burn assessment devices are useful to the burn team, how the various imaging devices work, and where the various burn imaging technologies fit into the spectrum of burn care will continue to be addressed. Technologies that can image a large surface area quickly, such as thermography or laser speckle imaging, may be suitable for initial burn assessment and triage. In the setting of presurgical planning, ultrasound or optical microscopy techniques, including optical coherence tomography, may prove useful. MSI, which actually has origins in burn care, may ultimately meet a high number of requirements for burn assessment in routine clinical use.

[1]  J. Hinshaw PROGRESSIVE CHANGES IN THE DEPTH OF BURNS. , 1963, Archives of surgery.

[2]  W. Kirschbaum Differentialdiagnose neurologischer Krankheitsbilder. , 1963 .

[3]  J. Gaston,et al.  TEMPERATURE MEASUREMENTS OF LOCALIZED PATHOLOGICAL PROCESSES * , 1964, Annals of the New York Academy of Sciences.

[4]  N. Georgiade,et al.  A clinical evaluation of the use of thermography in determining degree of burn injury. , 1966, Plastic and reconstructive surgery.

[5]  Catalin Vasilescu,et al.  Thermography in plastic surgery. , 1972, Journal of the Royal College of Surgeons of Edinburgh.

[6]  M E Hackett,et al.  The use of thermography in the assessment of depth of burn and blood supply of flaps, with preliminary reports on its use in Dupuytren's contracture and treatment of varicose ulcers. , 1974, British journal of plastic surgery.

[7]  M. Stern,et al.  In vivo evaluation of microcirculation by coherent light scattering , 1975, Nature.

[8]  J. Cantrell,et al.  Ultrasonic pulse-echo determination of thermal injury in deep dermal burns. , 1977, Medical physics.

[9]  J. Aindow,et al.  APPLICATION OF ULTRASOUND IN ASSESSING BURN DEPTH , 1979, The Lancet.

[10]  R Königová,et al.  Validity of clinical assessment of the depth of a thermal injury. , 1983, Acta chirurgiae plasticae.

[11]  R F Edlich,et al.  Improving the accuracy of burn-surface estimation. , 1985, Plastic and reconstructive surgery.

[12]  Evaluation of impedance technique for fluid-volume monitoring during hemodialysis , 1985, International journal of clinical monitoring and computing.

[13]  C W Hanke,et al.  Quantitative assessment of burn injury in porcine skin with high-frequency ultrasonic imaging. , 1986, Investigative radiology.

[14]  G. Leopold,et al.  B-mode ultrasonic echo determination of depth of thermal injury. , 1986, Burns, including thermal injury.

[15]  I. Goldfarb,et al.  Comparison of burn size estimates between prehospital reports and burn center evaluations. , 1986, The Journal of burn care & rehabilitation.

[16]  Martin A. Afromowitz,et al.  Clinical Evaluation of Burn Injuries Using an Optical Reflectance Technique , 1987, IEEE Transactions on Biomedical Engineering.

[17]  J. Callis,et al.  Multispectral imaging of burn wounds: a new clinical instrument for evaluating burn depth , 1988, IEEE Transactions on Biomedical Engineering.

[18]  R. Benya,et al.  Adverse reactions to indocyanine green: a case report and a review of the literature. , 1989, Catheterization and cardiovascular diagnosis.

[19]  N. McLean,et al.  New laser Doppler scanner, a valuable adjunct in burn depth assessment. , 1993, Burns : journal of the International Society for Burn Injuries.

[20]  P G Shakespeare,et al.  Timing of the thermographic assessment of burns. , 1996, Burns : journal of the International Society for Burn Injuries.

[21]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. , 1999, The Journal of investigative dermatology.

[22]  C. Serrano,et al.  Digital imaging in remote diagnosis of burns. , 1999, Burns : journal of the International Society for Burn Injuries.

[23]  J Marotz,et al.  Reflection-optical multispectral imaging method for objective determination of burn depth. , 1999, Burns : journal of the International Society for Burn Injuries.

[24]  N. Nishioka,et al.  Burn wound assessment in porcine skin using indocyanine green fluorescence. , 1999, The Journal of trauma.

[25]  C. Berry,et al.  The inter-rater reliability of estimating the size of burns from various burn area chart drawings. , 2000, Burns : journal of the International Society for Burn Injuries.

[26]  J. Jones,et al.  Determination of burn depth with noncontact ultrasonography. , 2000, The Journal of burn care & rehabilitation.

[27]  C. Skouras,et al.  An audit of the use of laser Doppler imaging (LDI) in the assessment of burns of intermediate depth. , 2001, Burns : journal of the International Society for Burn Injuries.

[28]  J. Still,et al.  Diagnosis of burn depth using laser-induced indocyanine green fluorescence: a preliminary clinical trial. , 2001, Burns : journal of the International Society for Burn Injuries.

[29]  G. Zonios,et al.  Skin melanin, hemoglobin, and light scattering properties can be quantitatively assessed in vivo using diffuse reflectance spectroscopy. , 2001, The Journal of investigative dermatology.

[30]  J. Briers,et al.  Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging. , 2001, Physiological measurement.

[31]  E. Chérin,et al.  A new ultrasound instrument for in vivo microimaging of mice. , 2002, Ultrasound in medicine & biology.

[32]  K. Jablonski,et al.  Laser Doppler imaging determines need for excision and grafting in advance of clinical judgment: a prospective blinded trial. , 2003, Burns.

[33]  O. Jones,et al.  The reliability of digital images when used to assess burn wounds , 2003, Journal of telemedicine and telecare.

[34]  A. Donner,et al.  Indocyanine green video angiographies help to identify burns requiring operation. , 2003, Burns : journal of the International Society for Burn Injuries.

[35]  Tzu-Chien Hsiao,et al.  Prediction of burn healing time using artificial neural networks and reflectance spectrometer , 2004, The Second Asian and Pacific Rim Symposium on Biophotonics, 2004. APBP 2004..

[36]  A. Papp,et al.  The progression of burn depth in experimental burns: a histological and methodological study. , 2004, Burns : journal of the International Society for Burn Injuries.

[37]  S. Jones,et al.  Telemedicine in acute plastic surgical trauma and burns. , 2004, Annals of the Royal College of Surgeons of England.

[38]  Barry Cense,et al.  Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomography. , 2004, Burns : journal of the International Society for Burn Injuries.

[39]  John W. Severinghaus,et al.  History of blood gas analysis. VII. Pulse oximetry , 1987, Journal of Clinical Monitoring.

[40]  A. N. Bashkatov,et al.  Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm , 2005 .

[41]  R. Bick,et al.  Observations on the microcirculation of the human burn wound using orthogonal polarization spectral imaging. , 2005, Burns : journal of the International Society for Burn Injuries.

[42]  O. Jones Measurements of the clinical competence of doctors and nurses to process telemedicine referrals for burns patients , 2005, Journal of telemedicine and telecare.

[43]  Lihong V. Wang,et al.  Imaging acute thermal burns by photoacoustic microscopy. , 2006, Journal of biomedical optics.

[44]  Antoni Nowakowski,et al.  Burn depths evaluation based on active dynamic IR thermal imaging--a preliminary study. , 2006, Burns : journal of the International Society for Burn Injuries.

[45]  D. Hart,et al.  Kinetics of blood flow during healing of excisional full‐thickness skin wounds in pigs as monitored by laser speckle perfusion imaging , 2006, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[46]  Victor J. Anselmo,et al.  Multispectral photographic analysis a new quantitative tool to assist in the early diagnosis of thermal burn depth , 2006, Annals of Biomedical Engineering.

[47]  D. Church,et al.  Burn Wound Infections , 2006, Clinical Microbiology Reviews.

[48]  W. Dickson,et al.  Mobile phones for the assessment of burns: we have the technology , 2007, Emergency Medicine Journal.

[49]  D. McGill,et al.  Assessment of burn depth: a prospective, blinded comparison of laser Doppler imaging and videomicroscopy. , 2007, Burns : journal of the International Society for Burn Injuries.

[50]  Lihong V. Wang,et al.  Biomedical Optics: Principles and Imaging , 2007 .

[51]  A. Holland,et al.  The Influence of Burn Wound Dressings on Laser Doppler Imaging Assessment of a Standardized Cutaneous Injury Model , 2007, Journal of burn care & research : official publication of the American Burn Association.

[52]  John S. Graham,et al.  Noninvasive Methods for Determining Lesion Depth From Vesicant Exposure , 2007, Journal of burn care & research : official publication of the American Burn Association.

[53]  Freddy T. Nguyen,et al.  Optical coherence tomography: a review of clinical development from bench to bedside. , 2007, Journal of biomedical optics.

[54]  Phillip Blondeel,et al.  Assessment of burn depth and burn wound healing potential. , 2008, Burns : journal of the International Society for Burn Injuries.

[55]  Giovanni Pellacani,et al.  Reflectance Confocal Microscopy for In Vivo Skin Imaging † , 2008, Photochemistry and photobiology.

[56]  W S Grundfest,et al.  Reflective terahertz imaging of porcine skin burns. , 2008, Optics letters.

[57]  Lihong V. Wang,et al.  Dark-Field Confocal Photoacoustic Microscopy , 2009 .

[58]  A. A. Altintas,et al.  Assessment of microcirculatory influence on cellular morphology in human burn wound healing using reflectance‐mode‐confocal microscopy , 2009, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[59]  Jeffrey W. Shupp,et al.  Critical Review of Burn Depth Assessment Techniques: Part I. Historical Review , 2009, Journal of burn care & research : official publication of the American Burn Association.

[60]  Lihong V. Wang Photoacoustic imaging and spectroscopy , 2009 .

[61]  Anthony J. Durkin,et al.  Quantitation and mapping of tissue optical properties using modulated imaging. , 2009, Journal of biomedical optics.

[62]  Jessica C. Ramella-Roman,et al.  Critical Review of Burn Depth Assessment Techniques: Part II. Review of Laser Doppler Technology , 2010, Journal of burn care & research : official publication of the American Burn Association.

[63]  J. Jeng,et al.  A Review of the Local Pathophysiologic Bases of Burn Wound Progression , 2010, Journal of burn care & research : official publication of the American Burn Association.

[64]  Olena Kravchuk,et al.  Ultrasound assessed thickness of burn scars in association with laser Doppler imaging determined depth of burns in paediatric patients. , 2010, Burns : journal of the International Society for Burn Injuries.

[65]  D. Boas,et al.  Laser speckle contrast imaging in biomedical optics. , 2010, Journal of biomedical optics.

[66]  L. Evers,et al.  The biology of burn injury , 2010, Experimental dermatology.

[67]  Maurice Mimoun,et al.  Retrospective analysis of photographic evaluation of burn depth. , 2011, Burns : journal of the International Society for Burn Injuries.

[68]  Bernard Choi,et al.  Noninvasive assessment of burn wound severity using optical technology: a review of current and future modalities. , 2011, Burns : journal of the International Society for Burn Injuries.

[69]  Nirmalya Ghosh,et al.  Tissue polarimetry: concepts, challenges, applications, and outlook. , 2011, Journal of biomedical optics.

[70]  B. Cairns,et al.  Burn care: are there sufficient providers and facilities? , 2011, Bulletin of the American College of Surgeons.

[71]  Sang June Yoon,et al.  In vivo imaging of human burn injuries with polarization-sensitive optical coherence tomography. , 2012, Journal of biomedical optics.

[72]  M. Roustit,et al.  Non‐invasive Assessment of Skin Microvascular Function in Humans: An Insight Into Methods , 2012, Microcirculation.

[73]  V. Tiwari Burn wound: How it differs from other wounds? , 2012, Indian Journal of Plastic Surgery.

[74]  Folke Sjöberg,et al.  Assessing paediatric scald injuries using Laser Speckle Contrast Imaging. , 2013, Burns : journal of the International Society for Burn Injuries.

[75]  Jessica C. Ramella-Roman,et al.  Novel Application of a Spatial Frequency Domain Imaging System to Determine Signature Spectral Differences Between Infected and Noninfected Burn Wounds , 2013, Journal of burn care & research : official publication of the American Burn Association.

[76]  B. Cairns,et al.  Photographic assessment of burn wounds: a simple strategy in a resource-poor setting. , 2013, Burns : journal of the International Society for Burn Injuries.

[77]  S. Jacques Optical properties of biological tissues: a review , 2013, Physics in medicine and biology.

[78]  M. Terakawa,et al.  In vivo photoacoustic molecular imaging of the distribution of serum albumin in rat burned skin. , 2013, Burns : journal of the International Society for Burn Injuries.

[79]  Bernard Choi,et al.  Spatial frequency domain imaging of burn wounds in a preclinical model of graded burn severity , 2013, Journal of biomedical optics.

[80]  Franck Marzani,et al.  Skin Parameter Map Retrieval from a Dedicated Multispectral Imaging System Applied to Dermatology/Cosmetology , 2013, Int. J. Biomed. Imaging.

[81]  Dongrong Xu,et al.  Review of spectral imaging technology in biomedical engineering: achievements and challenges , 2013, Journal of biomedical optics.

[82]  Tsutomu Araki,et al.  In vivo visualization of dermal collagen fiber in skin burn by collagen-sensitive second-harmonic-generation microscopy , 2013, Journal of biomedical optics.

[83]  Guolan Lu,et al.  Medical hyperspectral imaging: a review , 2014, Journal of biomedical optics.

[84]  William J. Brown,et al.  Deep tissue imaging using spectroscopic analysis of multiply scattered light , 2014 .

[85]  Satoko Kawauchi,et al.  Real-time photoacoustic imaging system for burn diagnosis. , 2014, Journal of biomedical optics.

[86]  Jacqueline Osland,et al.  Estimation of Burn Depth at Burn Centers in the United States: A Survey , 2014, Journal of burn care & research : official publication of the American Burn Association.

[87]  I. Oen,et al.  Photographic assessment of burn size and depth: reliability and validity. , 2014, Journal of wound care.

[88]  Jacob Yadegar,et al.  Dual-imaging system for burn depth diagnosis. , 2014, Burns : journal of the International Society for Burn Injuries.

[89]  Bernard Choi,et al.  Utility of spatial frequency domain imaging (SFDI) and laser speckle imaging (LSI) to non-invasively diagnose burn depth in a porcine model. , 2015, Burns : journal of the International Society for Burn Injuries.

[90]  Wei Xu,et al.  Point-of-Care Autofluorescence Imaging for Real-Time Sampling and Treatment Guidance of Bioburden in Chronic Wounds: First-in-Human Results , 2015, PloS one.

[91]  Roxana Savastru,et al.  Characterization of burns using hyperspectral imaging technique - a preliminary study. , 2015, Burns : journal of the International Society for Burn Injuries.

[92]  Nehemiah T. Liu,et al.  Machine learning in burn care and research: A systematic review of the literature. , 2015, Burns : journal of the International Society for Burn Injuries.

[93]  S. Gnyawali,et al.  High-Resolution Harmonics Ultrasound Imaging for Non-Invasive Characterization of Wound Healing in a Pre-Clinical Swine Model , 2015, PloS one.

[94]  Bernard Choi,et al.  Acute discrimination between superficial-partial and deep-partial thickness burns in a preclinical model with laser speckle imaging. , 2015, Burns : journal of the International Society for Burn Injuries.

[95]  Jeffrey E. Thatcher,et al.  Outlier detection and removal improves accuracy of machine learning approach to multispectral burn diagnostic imaging , 2015, Journal of biomedical optics.

[96]  L. Laflamme,et al.  Photograph-based diagnosis of burns in patients with dark-skin types: the importance of case and assessor characteristics. , 2015, Burns : journal of the International Society for Burn Injuries.

[97]  Taryn E. Travis,et al.  Examination of the Early Diagnostic Applicability of Active Dynamic Thermography for Burn Wound Depth Assessment and Concept Analysis , 2015, Journal of burn care & research : official publication of the American Burn Association.

[98]  Jeffrey E. Thatcher,et al.  Surgical wound debridement sequentially characterized in a porcine burn model with multispectral imaging. , 2015, Burns : journal of the International Society for Burn Injuries.

[99]  Jeffrey E. Thatcher,et al.  Multispectral and Photoplethysmography Optical Imaging Techniques Identify Important Tissue Characteristics in an Animal Model of Tangential Burn Excision , 2016, Journal of burn care & research : official publication of the American Burn Association.