FLT3 mutations in canine acute lymphocytic leukemia

[1]  J. Dufour,et al.  Cell lines , 2012, Spermatogenesis.

[2]  A. Tichelli,et al.  Expression of pSTAT5 predicts FLT3 internal tandem duplications in acute myeloid leukemia , 2010, Annals of Hematology.

[3]  A. Radford,et al.  RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias. , 2009, Experimental hematology.

[4]  M. McDevitt,et al.  250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. , 2008, Cancer research.

[5]  J. Radich,et al.  Structural and numerical variation of FLT3/ITD in pediatric AML. , 2008, Blood.

[6]  K. Takamiya,et al.  Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model. , 2006, Blood.

[7]  J. Modiano,et al.  Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans – man and his best friend share more than companionship , 2008, Chromosome Research.

[8]  A. Sterner-Kock,et al.  Selection of Reference Genes for Quantitative Real-time PCR Analysis in Canine Mammary Tumors Using the GeNorm Algorithm , 2006, Veterinary pathology.

[9]  K. Lindblad-Toh,et al.  The dog as a cancer model , 2006, Nature Biotechnology.

[10]  Jeremy W. Linsley,et al.  Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia. , 2006, Blood.

[11]  D. Small,et al.  FLT3 mutations: biology and treatment. , 2006, Hematology. American Society of Hematology. Education Program.

[12]  James A. Cuff,et al.  Genome sequence, comparative analysis and haplotype structure of the domestic dog , 2005, Nature.

[13]  Chunaram Choudhary,et al.  Signal Transduction of Oncogenic Flt3 , 2005, International journal of hematology.

[14]  Chunaram Choudhary,et al.  AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. , 2005, Blood.

[15]  C. Miething,et al.  FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. , 2005, Blood.

[16]  B. Madewell,et al.  In vitro Canine Distemper Virus Infection of Canine Lymphoid Cells: A Prelude to Oncolytic Therapy for Lymphoma , 2005, Clinical Cancer Research.

[17]  Dario Campana,et al.  FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. , 2005, Blood.

[18]  L. Shih,et al.  Internal tandem duplication of fms‐like tyrosine kinase 3 is associated with poor outcome in patients with myelodysplastic syndrome , 2004, Cancer.

[19]  Z. Steplewski,et al.  Canine lymphoma-associated antigens defined by murine monoclonal antibodies , 2004, Cancer Immunology, Immunotherapy.

[20]  I. Bernstein,et al.  Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. , 2003, Blood.

[21]  W. Hiddemann,et al.  The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. , 2003, Blood.

[22]  H. Drexler,et al.  FLT3 mutations in acute myeloid leukemia cell lines , 2003, Leukemia.

[23]  J. Griffin,et al.  The roles of FLT3 in hematopoiesis and leukemia. , 2002, Blood.

[24]  B. Smith,et al.  A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. , 2002, Blood.

[25]  J. Reilly,et al.  Identification of novel FLT‐3 Asp835 mutations in adult acute myeloid leukaemia , 2001, British journal of haematology.

[26]  M. Pfaffl,et al.  A new mathematical model for relative quantification in real-time RT-PCR. , 2001, Nucleic acids research.

[27]  T. Naoe,et al.  Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. , 2001, Blood.

[28]  E. Macewen,et al.  Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer , 2000, Cancer investigation.

[29]  T. Naoe,et al.  Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. , 1999, Blood.

[30]  H. Kaneko,et al.  Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. , 1996, Leukemia.

[31]  M. Nakaichi,et al.  Establishment and characterization of a new canine B-cell leukemia cell line. , 1996, The Journal of veterinary medical science.

[32]  H. Drexler,et al.  Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. , 1996, Leukemia.

[33]  M. Borowitz,et al.  Expression of the hematopoietic growth factor receptor FLT3 (STK-1/Flk2) in human leukemias. , 1996, Blood.

[34]  D. Birnbaum,et al.  Expression of FLT3 receptor and FLT3-ligand in human leukemia-lymphoma cell lines. , 1995, Leukemia.

[35]  D. Birnbaum,et al.  Expression of the FMS/KIT-like gene FLT3 in human acute leukemias of the myeloid and lymphoid lineages. , 1992, Blood.

[36]  P. Felsburg,et al.  An improved method for the isolation of enriched canine peripheral blood mononuclear cell and peripheral blood lymphocyte preparations. , 1989, Veterinary immunology and immunopathology.