MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin

[1]  S Tweedie,et al.  Methylation of genomes and genes at the invertebrate-vertebrate boundary , 1997, Molecular and cellular biology.

[2]  U. Hansen,et al.  Active repression mechanisms of eukaryotic transcription repressors. , 1996, Trends in genetics : TIG.

[3]  M. McArthur,et al.  A preference of histone H1 for methylated DNA. , 1996, The EMBO journal.

[4]  S. Rusconi,et al.  Transcriptional repression by methylation: cooperativity between a CpG cluster in the promoter and remote CpG‐rich regions , 1996, FEBS letters.

[5]  A. Bird,et al.  The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse , 1996, Nature Genetics.

[6]  K. Struhl,et al.  Chromatin Structure and RNA Polymerase II Connection: Implications for Transcription , 1996, Cell.

[7]  A. Bird,et al.  DNA methylation specifies chromosomal localization of MeCP2 , 1996, Molecular and cellular biology.

[8]  A. Bird,et al.  Binding of Histone H1 to DNA Is Indifferent to Methylation at CpG Sequences (*) , 1995, The Journal of Biological Chemistry.

[9]  A. Wolffe,et al.  Methylation at CpG Sequences Does Not Influence Histone H1 Binding to a Nucleosome Including a Xenopus borealis 5 S rRNA Gene (*) , 1995, The Journal of Biological Chemistry.

[10]  R. Adams,et al.  The effect of histone H1 and DNA methylation on transcription. , 1995, The Biochemical journal.

[11]  S Tweedie,et al.  Studies of DNA methylation in animals , 1995, Journal of Cell Science.

[12]  C. Hsieh,et al.  Dependence of transcriptional repression on CpG methylation density , 1994, Molecular and cellular biology.

[13]  A. Razin,et al.  DNA methylation and genomic imprinting , 1994, Cell.

[14]  J. Workman,et al.  Nucleosome binding by the constitutive transcription factor Sp1. , 1994, The Journal of biological chemistry.

[15]  S. Kass,et al.  Inactive chromatin spreads from a focus of methylation , 1993, Molecular and cellular biology.

[16]  A. Bird,et al.  Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. , 1993, Nucleic acids research.

[17]  A. Razin,et al.  Histone H1-mediated inhibition of transcription initiation of methylated templates in vitro. , 1993, The Journal of biological chemistry.

[18]  A. Moorman,et al.  Absence of somatic histone H1 in oocytes and preblastula embryos of Xenopus laevis. , 1993, Developmental biology.

[19]  Merigan Wh.  Colour vision: human V4? , 1993, Current biology : CB.

[20]  A. Bird,et al.  Effects of DNA methylation on DNA-binding proteins and gene expression. , 1993, Current opinion in genetics & development.

[21]  J. Hofsteenge,et al.  The repressor MDBP-2 is a member of the histone H1 family that binds preferentially in vitro and in vivo to methylated nonspecific DNA sequences. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[22]  A. Bird,et al.  Characterization of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA. , 1992, Nucleic acids research.

[23]  A. Bird,et al.  Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA , 1992, Cell.

[24]  A. Riggs,et al.  X-chromosome inactivation and cell memory. , 1992, Trends in genetics : TIG.

[25]  A. Bird,et al.  Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein. , 1992, The EMBO journal.

[26]  J. T. Kadonaga,et al.  Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II. , 1991, Science.

[27]  A. Razin,et al.  Inhibition of promoter activity by methylation: possible involvement of protein mediators. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[28]  R. Cole,et al.  The combination of DNA methylation and H1 histone binding inhibits the action of a restriction nuclease on plasmid DNA. , 1991, The Journal of biological chemistry.

[29]  Adrian Bird,et al.  DNA methylation inhibits transcription indirectly via a methyl-CpG binding protein , 1991, Cell.

[30]  L. M. Lira,et al.  Sequence-specific transcriptional antirepression of the Drosophila Krüppel gene by the GAGA factor. , 1991, The Journal of biological chemistry.

[31]  L. Babiss,et al.  The upstream factor-binding site is not essential for activation of transcription from the adenovirus major late promoter , 1990, Journal of virology.

[32]  B. Vogelstein,et al.  Suppression of human colorectal carcinoma cell growth by wild-type p53. , 1990, Science.

[33]  Robert L. Tanguay,et al.  In vivo footprint and methylation analysis by PCR-aided genomic sequencing: comparison of active and inactive X chromosomal DNA at the CpG island and promoter of human PGK-1. , 1990, Genes & development.

[34]  B. Safer,et al.  Identification and characterization of an adenovirus 2 major late promoter CAP sequence DNA-binding protein. , 1990, The Journal of biological chemistry.

[35]  D. Chasman,et al.  Activation of yeast polymerase II transcription by herpesvirus VP16 and GAL4 derivatives in vitro , 1989, Molecular and cellular biology.

[36]  A. Bird,et al.  Specific protection of methylated CpGs in mammalian nuclei , 1989, Cell.

[37]  A. Bird,et al.  Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs , 1989, Cell.

[38]  F. Watt,et al.  Cytosine methylation prevents binding to DNA of a HeLa cell transcription factor required for optimal expression of the adenovirus major late promoter. , 1988, Genes & development.

[39]  Young-Sun Lin,et al.  GAL4 derivatives function alone and synergistically with mammalian activators in vitro , 1988, Cell.

[40]  R. Losa,et al.  A bacteriophage RNA polymerase transcribes in vitro through a nucleosome core without displacing it , 1987, Cell.

[41]  E. Murray,et al.  Site specific demethylation in the promoter of human gamma‐globin gene does not alleviate methylation mediated suppression. , 1987, The EMBO journal.

[42]  R. Kornberg,et al.  Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones , 1987, Cell.

[43]  A. Graessmann,et al.  Chromatin structure is required to block transcription of the methylated herpes simplex virus thymidine kinase gene. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[44]  A. Graessmann,et al.  Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect. , 1985, Nucleic acids research.

[45]  H. Cedar,et al.  Effect of regional DNA methylation on gene expression. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[46]  O. Pongs,et al.  In vitro transcription with extracts of nuclei of Drosophila embryos. , 1985, Nucleic acids research.

[47]  M. Ehrlich,et al.  A protein from human placental nuclei binds preferentially to 5-methylcytosine-rich DNA , 1984, Nature.

[48]  A. Razin,et al.  In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[49]  H. Cedar,et al.  Expression of a cloned adenovirus gene is inhibited by in vitro methylation. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[50]  P. Starlinger,et al.  Studies on IS DNA , 1977 .