Nuclear Translocation of RELB Is Increased in Diseased Human Liver and Promotes Ductular Reaction and Biliary Fibrosis in Mice.
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Jakob Nikolas Kather | Lahiri Kanth Nanduri | J. Kather | D. Jäger | P. Schirmacher | S. Schölch | J. Stindt | A. Waisman | M. Heikenwalder | B. Goeppert | S. Mueller | H. Schulze‐Bergkamen | Anna-Lena Scherr | V. Keitel | T. Longerich | J. Banales | N. Hövelmeyer | G. Gdynia | S. Roessler | C. Rupp | N. Schmitt | K. Breuhahn | Toni Urbanik | D. Heide | B. Köhler | C. Elssner | Nicole Kautz | J. Hetzer | Lars Ismail | María García-Beccaria | Jenny Hetzer | T. Urbanik
[1] T. Karlsen,et al. Hepatic Stem/Progenitor Cell Activation Differs between Primary Sclerosing and Primary Biliary Cholangitis. , 2017, The American journal of pathology.
[2] S. Glaser,et al. Mechanisms of cholangiocyte responses to injury. , 2017, Biochimica et biophysica acta. Molecular basis of disease.
[3] Darjus F. Tschaharganeh,et al. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. , 2017, Cancer cell.
[4] S. V. D. van de Graaf,et al. Bile Acid Uptake Transporters as Targets for Therapy , 2017, Digestive Diseases.
[5] T. Luedde,et al. IκB kinaseα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell‐death mediator receptor‐interacting protein kinase 1 , 2016, Hepatology.
[6] C. Ware,et al. The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100 , 2016, Science Signaling.
[7] M. Roncalli,et al. Quantitation of the Rank-Rankl Axis in Primary Biliary Cholangitis , 2016, PloS one.
[8] Vinay Tergaonkar,et al. Noncanonical NF-κB Signaling in Health and Disease. , 2016, Trends in molecular medicine.
[9] F. Bassermann,et al. BCL3 Reduces the Sterile Inflammatory Response in Pancreatic and Biliary Tissues. , 2016, Gastroenterology.
[10] C. Levy,et al. Current Concepts in Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis , 2015, Clinical and Translational Gastroenterology.
[11] T. Matsui,et al. Disease susceptibility genes shared by primary biliary cirrhosis and Crohn’s disease in the Japanese population , 2015, Journal of Human Genetics.
[12] G. Alpini,et al. CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. , 2015, The Journal of clinical investigation.
[13] P. Kang,et al. A new Mdr2(-/-) mouse model of sclerosing cholangitis with rapid fibrosis progression, early-onset portal hypertension, and liver cancer. , 2015, The American journal of pathology.
[14] J. L. Bermejo,et al. Nuclear Expression of the Deubiquitinase CYLD Is Associated with Improved Survival in Human Hepatocellular Carcinoma , 2014, PloS one.
[15] D. Jäger,et al. Beyond Cell Death – Antiapoptotic Bcl-2 Proteins Regulate Migration and Invasion of Colorectal Cancer Cells In Vitro , 2013, PloS one.
[16] D. Jäger,et al. Liver specific deletion of CYLDexon7/8 induces severe biliary damage, fibrosis and increases hepatocarcinogenesis in mice. , 2012, Journal of hepatology.
[17] N. LaRusso,et al. Up‐regulation of microRNA 506 leads to decreased Cl−/HCO3− anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis , 2012, Hepatology.
[18] G. Kollias,et al. Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer. , 2012, Cancer cell.
[19] Shao-Cong Sun. The noncanonical NF‐κB pathway , 2012, Immunological reviews.
[20] C. Beaumont,et al. Protoporphyrin retention in hepatocytes and Kupffer cells prevents sclerosing cholangitis in erythropoietic protoporphyria mouse model. , 2011, Gastroenterology.
[21] T. Luedde,et al. NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma , 2011, Nature Reviews Gastroenterology &Hepatology.
[22] Thomas J. Fuchs,et al. TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer. , 2010, Cancer cell.
[23] M. Ebrahimkhani,et al. The c‐Rel subunit of nuclear factor‐κB regulates murine liver inflammation, wound‐healing, and hepatocyte proliferation , 2010, Hepatology.
[24] S-C Sun. CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes , 2010, Cell Death and Differentiation.
[25] M. Kurrer,et al. A lymphotoxin-driven pathway to hepatocellular carcinoma. , 2009, Cancer cell.
[26] M. Karin,et al. Regulation and function of NF-kappaB transcription factors in the immune system. , 2009, Annual review of immunology.
[27] J. Olynyk,et al. Lymphotoxin‐β receptor signaling regulates hepatic stellate cell function and wound healing in a murine model of chronic liver injury , 2009, Hepatology.
[28] S. Ghosh,et al. Shared Principles in NF-κB Signaling , 2008, Cell.
[29] P. Galle,et al. Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD , 2007, The Journal of experimental medicine.
[30] K. Zatloukal,et al. A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis. , 2007, The American journal of pathology.
[31] G. Gores,et al. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. , 2006, The Journal of clinical investigation.
[32] K. Zatloukal,et al. Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. , 2006, The American journal of pathology.
[33] I. Leclercq,et al. NF-kappaB activation, rather than TNF, mediates hepatic inflammation in a murine dietary model of steatohepatitis. , 2005, Gastroenterology.
[34] O. Cummings,et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease , 2005, Hepatology.
[35] D. Keppler,et al. Expression and localization of hepatobiliary transport proteins in progressive familial intrahepatic cholestasis , 2005, Hepatology.
[36] J. Iredale,et al. Modeling liver fibrosis in rodents. , 2005, Methods in molecular medicine.
[37] N. LaRusso,et al. The cholangiopathies: disorders of biliary epithelia. , 2004, Gastroenterology.
[38] H. Cortez‐Pinto,et al. Hepatocyte Apoptosis, Expression of Death Receptors, and Activation of NF-κB in the Liver of Nonalcoholic and Alcoholic Steatohepatitis Patients , 2004, The American Journal of Gastroenterology.
[39] D. Green,et al. RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation , 2003, Journal of Biological Chemistry.
[40] D. Green,et al. RelB/p50 dimers are differentially regulated by TNF-α and lymphotoxin-β receptor activation: critical roles for p100 , 2003 .
[41] Jürgen R. Müller,et al. Lymphotoxin β Receptor Induces Sequential Activation of Distinct NF-κB Factors via Separate Signaling Pathways* , 2003, The Journal of Biological Chemistry.
[42] S. Curley,et al. Role of Rel/NF‐κB transcription factors in apoptosis of human hepatocellular carcinoma cells , 2002, Cancer.
[43] M. Magnuson,et al. DNA excision in liver by an albumin‐Cre transgene occurs progressively with age , 2000, Genesis.
[44] J. Olynyk,et al. Oval cell numbers in human chronic liver diseases are directly related to disease severity. , 1999, The American journal of pathology.
[45] P. Scheuer. Pathologic Features and Evolution of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis , 1998 .
[46] J. Hoofnagle,et al. Classification of chronic hepatitis: Diagnosis, grading and staging , 1994, Hepatology.
[47] R. Wiesner,et al. Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis , 1981, Hepatology.