Perspective: Multiomics and Machine Learning Help Unleash the Alternative Food Potential of Microalgae

[1]  P. Wood,et al.  A Review of the Alternative Protein Industry , 2022, Current Opinion in Food Science.

[2]  T. Laomettachit,et al.  mSRFR: a machine learning model using microalgal signature features for ncRNA classification , 2022, BioData Mining.

[3]  Joshua S. Yuan,et al.  Machine learning-informed and synthetic biology-enabled semi-continuous algal cultivation to unleash renewable fuel productivity , 2022, Nature communications.

[4]  M. Kieliszek,et al.  Yeast Protein as an Easily Accessible Food Source , 2022, Metabolites.

[5]  S. A. Kaliji,et al.  Review of factors affecting consumer acceptance of cultured meat , 2021, Appetite.

[6]  George Ifrim,et al.  Control of Microalgae Growth in Artificially Lighted Photobioreactors Using Metaheuristic-Based Predictions , 2021, Sensors.

[7]  M. Helmy,et al.  GeneCloudOmics: A Data Analytic Cloud Platform for High-Throughput Gene Expression Analysis , 2021, Frontiers in Bioinformatics.

[8]  Xiang Chen,et al.  Confocal hyperspectral microscopic imager for the detection and classification of individual microalgae. , 2021, Optics express.

[9]  A. Bakhsh,et al.  Evaluation of Rheological and Sensory Characteristics of Plant-Based Meat Analog with Comparison to Beef and Pork , 2021, Food science of animal resources.

[10]  S. Wuertz,et al.  Microbial community-based protein production from wastewater for animal feed applications. , 2021, Bioresource technology.

[11]  Mohammad Hossein Morowvat,et al.  Bioinformatics Analysis and Identification of Phytoene Synthase Gene in Microalgae. , 2021, Recent patents on biotechnology.

[12]  Dukka B Kc,et al.  A deep learning based approach for prediction of Chlamydomonas reinhardtii phosphorylation sites , 2021, Scientific Reports.

[13]  M. Wiedmann,et al.  Development of predictive models evaluating the spoilage-delaying effect of a bioprotective culture on different yeast species in yogurt. , 2021, Journal of dairy science.

[14]  Valeria Villanova,et al.  Mixotrophy in diatoms: molecular mechanism and industrial potential. , 2021, Physiologia plantarum.

[15]  E. P. Hudson,et al.  Wide range of metabolic adaptations to the acquisition of the Calvin cycle revealed by comparison of microbial genomes , 2021, PLoS Comput. Biol..

[16]  A. Salter,et al.  Role of novel protein sources in sustainably meeting future global requirements , 2021, Proceedings of the Nutrition Society.

[17]  Anushya Muruganujan,et al.  The Gene Ontology resource: enriching a GOld mine , 2020, Nucleic Acids Res..

[18]  L. Pastrana,et al.  Microalgae Encapsulation Systems for Food, Pharmaceutical and Cosmetics Applications , 2020, Marine drugs.

[19]  Sean Peisert,et al.  Machine learning for metabolic engineering: A review. , 2020, Metabolic engineering.

[20]  I-Min A. Chen,et al.  Genomes OnLine Database (GOLD) v.8: overview and updates , 2020, Nucleic Acids Res..

[21]  D. Wong,et al.  De novo transcriptome analysis of Chlorella sorokiniana: effect of glucose assimilation, and moderate light intensity , 2020, Scientific Reports.

[22]  F. Boukid.  Plant-based meat analogues: from niche to mainstream , 2020, European Food Research and Technology.

[23]  Sailing He,et al.  Classification, identification, and growth stage estimation of microalgae based on transmission hyperspectral microscopic imaging and machine learning. , 2020, Optics express.

[24]  Kumar Selvarajoo,et al.  Systems biology approaches integrated with artificial intelligence for optimized metabolic engineering , 2020, Metabolic Engineering Communications.

[25]  J. Beddington,et al.  The urgency of food system transformation is now irrefutable , 2020, Nature Food.

[26]  Gulshan Kumar,et al.  Bioengineering of Microalgae: Recent Advances, Perspectives, and Regulatory Challenges for Industrial Application , 2020, Frontiers in Bioengineering and Biotechnology.

[27]  M. Russell,et al.  Low Molecular Weight Volatile Organic Compounds Indicate Grazing by the Marine Rotifer Brachionus plicatilis on the Microalgae Microchloropsis salina , 2020, Metabolites.

[28]  Nicole E. Negowetti,et al.  Scientific, sustainability and regulatory challenges of cultured meat , 2020, Nature Food.

[29]  Lars M Blank,et al.  Machine Learning Applications for Mass Spectrometry-Based Metabolomics , 2020, Metabolites.

[30]  H. Pereira,et al.  Isolation and Characterization of Novel Chlorella Vulgaris Mutants With Low Chlorophyll and Improved Protein Contents for Food Applications , 2020, Frontiers in Bioengineering and Biotechnology.

[31]  P. Ralph,et al.  Emerging Technologies in Algal Biotechnology: Toward the Establishment of a Sustainable, Algae-Based Bioeconomy , 2020, Frontiers in Plant Science.

[32]  Francis J. Fields,et al.  Microalgae as a future food source. , 2020, Biotechnology advances.

[33]  P. Show,et al.  A review on microalgae cultivation and harvesting, and their biomass extraction processing using ionic liquids , 2020, Bioengineered.

[34]  N. Merghoub,et al.  Microalgae polysaccharides: the new sustainable bioactive products for the development of plant bio-stimulants? , 2019, World Journal of Microbiology and Biotechnology.

[35]  Chris Sander,et al.  Pathway Commons 2019 Update: integration, analysis and exploration of pathway data , 2019, Nucleic Acids Res..

[36]  M. Maffei,et al.  Combined resistance to oxidative stress and reduced antenna size enhance light-to-biomass conversion efficiency in Chlorella vulgaris cultures , 2019, Biotechnology for Biofuels.

[37]  Sudha Shukal,et al.  Systematic engineering for high-yield production of viridiflorol and amorphadiene in auxotrophic Escherichia coli. , 2019, Metabolic engineering.

[38]  T. Lafarga.  Effect of microalgal biomass incorporation into foods: Nutritional and sensorial attributes of the end products , 2019, Algal Research.

[39]  J. Masojídek,et al.  Development of thin-layer cascades for microalgae cultivation: milestones (review) , 2019, Folia Microbiologica.

[40]  M. Feldman,et al.  Predicting microbial growth in a mixed culture from growth curve data , 2019, Proceedings of the National Academy of Sciences.

[41]  P. Show,et al.  Microalgae: A potential alternative to health supplementation for humans , 2019, Food Science and Human Wellness.

[42]  Neil Swainston,et al.  Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli. , 2019, ACS synthetic biology.

[43]  Christopher M. Wharton,et al.  Plant-Based Diets: Considerations for Environmental Impact, Protein Quality, and Exercise Performance , 2018, Nutrients.

[44]  Ryuei Nishii,et al.  Statistical and Machine Learning Approaches to Predict Gene Regulatory Networks From Transcriptome Datasets , 2018, Front. Plant Sci..

[45]  A. Mathys,et al.  Trends in Microalgae Incorporation Into Innovative Food Products With Potential Health Benefits , 2018, Front. Nutr..

[46]  Alán Aspuru-Guzik,et al.  Inverse molecular design using machine learning: Generative models for matter engineering , 2018, Science.

[47]  A. Yurchenko,et al.  In silico Analyses of Transcriptomes of the Marine Green Microalga Dunaliella tertiolecta: Identification of Sequences Encoding P-type ATPases , 2018, Molecular Biology.

[48]  Pratyoosh Shukla,et al.  Recent developments in synthetic biology and metabolic engineering in microalgae towards biofuel production , 2018, Biotechnology for Biofuels.

[49]  T. Nemecek,et al.  Reducing food’s environmental impacts through producers and consumers , 2018, Science.

[50]  L. Keeling,et al.  Towards Farm Animal Welfare and Sustainability , 2018, Animals : an open access journal from MDPI.

[51]  Maria J Barbosa,et al.  Can We Approach Theoretical Lipid Yields in Microalgae? , 2018, Trends in biotechnology.

[52]  G. Dugo,et al.  Production of single cell protein (SCP) from food and agricultural waste by using Saccharomyces cerevisiae , 2018, Natural product research.

[53]  S. Vaidyanathan,et al.  Microwave-Assisted Extraction for Microalgae: From Biofuels to Biorefinery , 2018, Biology.

[54]  M. I. Hosoglu.  Aroma characterization of five microalgae species using solid-phase microextraction and gas chromatography-mass spectrometry/olfactometry. , 2018 .

[55]  Pooja Singh,et al.  Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches. , 2018, Journal of biotechnology.

[56]  Anneli Ritala,et al.  Single Cell Protein—State-of-the-Art, Industrial Landscape and Patents 2001–2016 , 2017, Front. Microbiol..

[57]  Jo‐Shu Chang,et al.  Recent Developments on Genetic Engineering of Microalgae for Biofuels and Bio‐Based Chemicals , 2017, Biotechnology journal.

[58]  M. Ozen,et al.  Investigation of in vitro digestibility of dietary microalga Chlorella vulgaris and cyanobacterium Spirulina platensis as a nutritional supplement , 2017, 3 Biotech.

[59]  B. R. Gurjar,et al.  Microalgae: An emerging source of energy based bio-products and a solution for environmental issues , 2017 .

[60]  Daniela Morales-Sánchez,et al.  Heterotrophic cultivation of microalgae: production of metabolites of commercial interest , 2017 .

[61]  L. Stein,et al.  Reactome pathway analysis: a high-performance in-memory approach , 2017, BMC Bioinformatics.

[62]  L. Colla,et al.  Potential application of microalga Spirulina platensis as a protein source. , 2017, Journal of the science of food and agriculture.

[63]  M. Ellies-Oury,et al.  An innovative approach combining Animal Performances, nutritional value and sensory quality of meat. , 2016, Meat science.

[64]  C. Blecker,et al.  Microalgae as a potential source of single-cell proteins. A review , 2016, BASE.

[65]  S. Vaidyanathan,et al.  Proteome response of Phaeodactylum tricornutum, during lipid accumulation induced by nitrogen depletion , 2016, Algal research.

[66]  Ian F. Thorpe,et al.  Current advances in molecular, biochemical, and computational modeling analysis of microalgal triacylglycerol biosynthesis. , 2016, Biotechnology advances.

[67]  P. Wangikar,et al.  Metabolic model of Synechococcus sp. PCC 7002: Prediction of flux distribution and network modification for enhanced biofuel production. , 2016, Bioresource technology.

[68]  W. Verstraete,et al.  Microbial protein: future sustainable food supply route with low environmental footprint , 2016, Microbial biotechnology.

[69]  Jonas Osterloff,et al.  Computational Visual Stress Level Analysis of Calcareous Algae Exposed to Sedimentation , 2016, PloS one.

[70]  Pratyoosh Shukla,et al.  Metabolic Engineering of Microalgal Based Biofuel Production: Prospects and Challenges , 2016, Front. Microbiol..

[71]  Ben Hankamer,et al.  Challenges and opportunities for hydrogen production from microalgae , 2016, Plant biotechnology journal.

[72]  J. Nicaud,et al.  Engineering Yarrowia lipolytica to produce biodiesel from raw starch , 2015, Biotechnology for Biofuels.

[73]  J. Costa,et al.  Biologically Active Metabolites Synthesized by Microalgae , 2015, BioMed research international.

[74]  Gabriella Caruso,et al.  Microbial Toxins and Related Contamination in the Food Industry , 2015 .

[75]  Prabuddha L. Gupta,et al.  A mini review: photobioreactors for large scale algal cultivation , 2015, World Journal of Microbiology and Biotechnology.

[76]  Maria J. Barbosa,et al.  Food and feed products from micro-algae: Market opportunities and challenges for the EU , 2015 .

[77]  A. Mišan,et al.  Determination of Volatile Organic Compounds in Selected Strains of Cyanobacteria , 2015 .

[78]  B. Chachuat,et al.  A model of chlorophyll fluorescence in microalgae integrating photoproduction, photoinhibition and photoregulation. , 2015, Journal of biotechnology.

[79]  A. Knulst,et al.  Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[80]  R. Parra-Saldívar,et al.  Extraction and purification of high-value metabolites from microalgae: essential lipids, astaxanthin and phycobiliproteins , 2014, Microbial biotechnology.

[81]  Guoyao Wu,et al.  Production and supply of high‐quality food protein for human consumption: sustainability, challenges, and innovations , 2014, Annals of the New York Academy of Sciences.

[82]  K. Flynn,et al.  In silico optimization for production of biomass and biofuel feedstocks from microalgae , 2014, Journal of Applied Phycology.

[83]  Kathleen A. Curran,et al.  Design of synthetic yeast promoters via tuning of nucleosome architecture , 2014, Nature Communications.

[84]  Philip T Pienkos,et al.  Strain, biochemistry, and cultivation-dependent measurement variability of algal biomass composition. , 2014, Analytical biochemistry.

[85]  Hal S Alper,et al.  Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production , 2014, Nature Communications.

[86]  K. Muylaert,et al.  Evaluation of the volatile composition and sensory properties of five species of microalgae. , 2013, Journal of agricultural and food chemistry.

[87]  N. Szabo,et al.  Safety evaluation of Whole Algalin Protein (WAP) from Chlorella protothecoides. , 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[88]  R. Bhatia,et al.  Microorganisms: a marvelous source of single cell proteins. , 2013 .

[89]  L. Day.  Proteins from land plants – Potential resources for human nutrition and food security , 2013 .

[90]  M. Borowitzka.  High-value products from microalgae—their development and commercialisation , 2013, Journal of Applied Phycology.

[91]  M. Borowitzka.  High-value products from microalgae—their development and commercialisation , 2013, Journal of Applied Phycology.

[92]  Wei Zhang,et al.  Biodiesel production from algae oil high in free fatty acids by two-step catalytic conversion. , 2012, Bioresource technology.

[93]  Eleftherios Bonos,et al.  Microalgae: a novel ingredient in nutrition , 2011, International journal of food sciences and nutrition.

[94]  Viatcheslav Kafarov,et al.  MICROALGAE BASED BIOREFINERY: ISSUES TO CONSIDER , 2011 .

[95]  Zhihua Zhou,et al.  Network Identification and Flux Quantification of Glucose Metabolism in Rhodobacter sphaeroides under Photoheterotrophic H2-Producing Conditions , 2011, Journal of bacteriology.

[96]  S. Mayfield,et al.  Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae , 2011, Microbial cell factories.

[97]  J. Perales,et al.  Effect of Nitrogen and Phosphorus Concentration on Their Removal Kinetic in Treated Urban Wastewater by Chlorella Vulgaris , 2011, International journal of phytoremediation.

[98]  Younes Ghasemi,et al.  Single cell protein: production and process. , 2011 .

[99]  Xueyang Feng,et al.  Metabolic Flux Analysis of the Mixotrophic Metabolisms in the Green Sulfur Bacterium Chlorobaculum tepidum* , 2010, The Journal of Biological Chemistry.

[100]  Clemens Posten,et al.  Design principles of photo‐bioreactors for cultivation of microalgae , 2009 .

[101]  C. Rhodes,et al.  Oil from Algae; Salvation from Peak Oil? , 2009, Science progress.

[102]  Masa Tsuchiya,et al.  Predicting Novel Features of Toll-Like Receptor 3 Signaling in Macrophages , 2009, PloS one.

[103]  Humberto J Morris,et al.  Utilisation of Chlorella vulgaris cell biomass for the production of enzymatic protein hydrolysates. , 2008, Bioresource technology.

[104]  C. Ugwu,et al.  Photobioreactors for mass cultivation of algae. , 2008, Bioresource technology.

[105]  Y. Chisti.  Biodiesel from microalgae. , 2007, Biotechnology advances.

[106]  E. Becker.  Micro-algae as a source of protein. , 2007, Biotechnology advances.

[107]  Hongwu Ma,et al.  Metabolic flux analysis of the two astaxanthin-producing microorganisms Haematococcus pluvialis and Phaffia rhodozyma in the pure and mixed cultures. , 2006, Biotechnology journal.

[108]  Christoph Wittmann,et al.  Accumulation of Homolanthionine and Activation of a Novel Pathway for Isoleucine Biosynthesis in Corynebacterium glutamicum McbR Deletion Strains , 2006, Journal of bacteriology.

[109]  A H Geeraerd,et al.  GInaFiT, a freeware tool to assess non-log-linear microbial survivor curves. , 2005, International journal of food microbiology.

[110]  V. C. Sgarbieri,et al.  Yeast (Saccharomyces cerevisiae) protein concentrate: preparation, chemical composition, and nutritional and functional properties. , 2005, Journal of agricultural and food chemistry.

[111]  O. Pulz,et al.  Valuable products from biotechnology of microalgae , 2004, Applied Microbiology and Biotechnology.

[112]  C. Adley,et al.  An evaluation of five preservation techniques and conventional freezing temperatures of −20°C and −85°C for long‐term preservation of Campylobacter jejuni , 2004 .

[113]  Giuseppe Torzillo,et al.  Biological constraints in algal biotechnology , 2003 .

[114]  M. Westendorf,et al.  Brewing by-products: their use as animal feeds. , 2002, The Veterinary clinics of North America. Food animal practice.

[115]  Arnaud Muller-Feuga,et al.  The role of microalgae in aquaculture: situation and trends , 2000, Journal of Applied Phycology.

[116]  James P. Hoffmann,et al.  WASTEWATER TREATMENT WITH SUSPENDED AND NONSUSPENDED ALGAE , 1998 .

[117]  Malcolm R. Brown,et al.  Nutritional properties of microalgae for mariculture , 1997 .

[118]  J. Larkin,et al.  MATHEMATICAL MODELING OF MICROBIAL GROWTH: A REVIEW , 1994 .

[119]  A. Jensen.  Present and future needs for algae and algal products , 1993, Hydrobiologia.

[120]  J. Fábregas,et al.  Vitamin content of four marine microalgae. Potential use as source of vitamins in nutrition , 1990, Journal of Industrial Microbiology.

[121]  C. Genigeorgis,et al.  Predicting the Safe Storage of Fresh Fish Under Modified Atmospheres with Respect to Clostridium botulinum Toxigenesis by Modeling Length of the Lag Phase of Growth. , 1990, Journal of food protection.

[122]  B. Tchorbanov,et al.  Enzymatic hydrolysis of cell proteins in green algae Chlorella and Scenedesmus after extraction with organic solvents , 1988 .

[123]  B. Macris,et al.  Protein Content and Amino Acid Composition of Certain Fungi Evaluated for Microbial Protein Production , 1975 .

[124]  S. Martin,et al.  Initiation of staphylococcal growth in processed meat environments. , 1971, Applied microbiology.

[125]  J. William Ahwood,et al.  CLASSIFICATION , 1931, Foundations of Familiar Language.

[126]  Jianping Wu.  Emerging sources and applications of alternative proteins: An introduction. , 2022, Advances in food and nutrition research.

[127]  Ahmed M. Abdel-Azeem,et al.  Endophytic Fungi as a New Source of Antirheumatoid Metabolites , 2019, Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases.

[128]  M. Javed,et al.  Engineering the metabolic pathways of lipid biosynthesis to develop robust microalgal strains for biodiesel production , 2019, Biotechnology and applied biochemistry.

[129]  Y. Wang,et al.  Pea: A Sustainable Vegetable Protein Crop , 2017 .

[130]  B. Klamczynska,et al.  Heterotrophic Microalgae: A Scalable and Sustainable Protein Source , 2017 .

[131]  Nadine Eberhardt,et al.  Algal Culturing Techniques , 2016 .

[132]  Tanya Barrett,et al.  The Gene Expression Omnibus Database , 2016, Statistical Genomics.

[133]  Rehab H. Mahmoud,et al.  Closed photobioreactor for microalgae biomass production under indoor growth conditions , 2016 .

[134]  J. Sanders,et al.  Techno-economical evaluation of protein extraction for microalgae biorefinery , 2016 .

[135]  Christien Enzing,et al.  Microalgae-based products for the food and feed sector: an outlook for Europe , 2014 .

[136]  Dehua Liu,et al.  Microbial oil production from various carbon sources and its use for biodiesel preparation , 2013 .

[137]  Navid R. Moheimani,et al.  Open pond culture systems , 2013 .

[138]  Wei Zhang,et al.  The contamination and control of biological pollutants in mass cultivation of microalgae. , 2013, Bioresource technology.

[139]  R. Tedeschi,et al.  Collection and preservation of frozen microorganisms. , 2011, Methods in molecular biology.

[140]  T.J.A. Finnigan,et al.  Mycoprotein: origins, production and properties , 2011 .

[141]  Teresa M. Mata,et al.  Microalgae for biodiesel production and other applications: A review , 2010 .

[142]  Susumu Goto,et al.  The KEGG resource for deciphering the genome , 2004, Nucleic Acids Res..

[143]  A. Richmond,et al.  Principles for attaining maximal microalgal productivity in photobioreactors: an overview , 2004, Hydrobiologia.