Mesenchymal Stem Cell-Derived Exosomes: Hope for Spinal Cord Injury Repair

[1]  Jianqing Gao,et al.  Transplantation of Human Mesenchymal Stem Cell-Derived Exosomes Immobilized in An Adhesive Hydrogel for Effective Treatment of Spinal Cord Injury. , 2020, Nano letters.

[2]  Xiaosheng Ma,et al.  Exosomes from Long Noncoding RNA-Gm37494-ADSCs Repair Spinal Cord Injury via Shifting Microglial M1/M2 Polarization , 2020, Inflammation.

[3]  Chun-yang Meng,et al.  Bone marrow mesenchymal stem cell-derived exosomal microRNA-124-3p attenuates neurological damage in spinal cord ischemia-reperfusion injury by downregulating Ern1 and promoting M2 macrophage polarization , 2020, Arthritis Research & Therapy.

[4]  Jin Fan,et al.  Exosomes derived from GIT1-overexpressing bone marrow mesenchymal stem cells promote traumatic spinal cord injury recovery in a rat model , 2020, The International journal of neuroscience.

[5]  Yingxin Pang,et al.  Exosomes derived from human umbilical cord mesenchymal stem cells inhibit vein graft intimal hyperplasia and accelerate reendothelialization by enhancing endothelial function , 2020 .

[6]  Chenggang Li,et al.  Exosomes derived from miR-544-modified mesenchymal stem cells promote recovery after spinal cord injury , 2020, Archives of physiology and biochemistry.

[7]  J. Gruenberg,et al.  ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes , 2020, The Journal of cell biology.

[8]  Jinli Wang,et al.  Boosting the Biogenesis and Secretion of Mesenchymal Stem Cell-Derived Exosomes , 2020, bioRxiv.

[9]  Raghu Kalluri,et al.  The biology, function, and biomedical applications of exosomes , 2020, Science.

[10]  Jin Fan,et al.  Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization , 2020, Journal of Neuroinflammation.

[11]  T. Yu,et al.  Exosomes secreted from miRNA-29b-modified mesenchymal stem cells repaired spinal cord injury in rats , 2019, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[12]  M. Li,et al.  miR-21 deficiency contributes to the impaired protective effects of obese rat mesenchymal stem cell-derived exosomes against spinal cord injury. , 2019, Biochimie.

[13]  Xiao-Ming Yin,et al.  Exosomes Derived from miR-126-modified MSCs Promote Angiogenesis and Neurogenesis and Attenuate Apoptosis after Spinal Cord Injury in Rats , 2019, Neuroscience.

[14]  Zhongzheng Zhi,et al.  MiR-21 derived from the exosomes of MSCs regulates the death and differentiation of neurons in patients with spinal cord injury , 2019, Gene Therapy.

[15]  W. Huckle,et al.  Human Bone Marrow-Derived Mesenchymal Stem Cells Home via the PI3K-Akt, MAPK, and Jak/Stat Signaling Pathways in Response to Platelet-Derived Growth Factor , 2019, Stem Cells and Development.

[16]  Xiu-Li Guo,et al.  New insight into isolation, identification techniques and medical applications of exosomes. , 2019, Journal of controlled release : official journal of the Controlled Release Society.

[17]  D. Offen,et al.  Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury. , 2019, ACS nano.

[18]  Haichun Liu,et al.  Exosomes from Bone Marrow Mesenchymal Stem Cells Inhibit Neuronal Apoptosis and Promote Motor Function Recovery via the Wnt/β-catenin Signaling Pathway , 2019, Cell transplantation.

[19]  Sheng Tu,et al.  Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies , 2019, Stem Cell Research & Therapy.

[20]  K. Rezvani,et al.  Mesenchymal stem cell-derived exosomes for clinical use , 2019, Bone Marrow Transplantation.

[21]  G. Hawryluk,et al.  Modern Medical Management of Spinal Cord Injury , 2019, Current Neurology and Neuroscience Reports.

[22]  Zhen Wang,et al.  Mesenchymal stem cell derived EVs mediate neuroprotection after spinal cord injury in rats via the microRNA-21-5p/FasL gene axis. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[23]  V. Vlassov,et al.  Extra Purified Exosomes from Human Placenta Contain an Unpredictable Small Number of Different Major Proteins , 2019, International journal of molecular sciences.

[24]  Ruiyi Zhang,et al.  Bone Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Recovery Following Spinal Cord Injury via Improvement of the Integrity of the Blood-Spinal Cord Barrier , 2019, Front. Neurosci..

[25]  Yoichi Yamada,et al.  Clinical Potential and Current Progress of Dental Pulp Stem Cells for Various Systemic Diseases in Regenerative Medicine: A Concise Review , 2019, International journal of molecular sciences.

[26]  W. Yuan,et al.  miRNA Profiling of Exosomes from Spontaneous Hypertensive Rats Using Next-Generation Sequencing , 2019, Journal of Cardiovascular Translational Research.

[27]  Jin Fan,et al.  Exosomes Derived from Bone Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by Suppressing the Activation of A1 Neurotoxic Reactive Astrocytes. , 2019, Journal of neurotrauma.

[28]  A. Parham,et al.  Immunomodulatory effects of mesenchymal stem cells on leukocytes with emphasis on neutrophils. , 2018, Immunobiology.

[29]  D. Sabry,et al.  Role of mesenchymal stem cells exosomes derived microRNAs; miR-136, miR-494 and miR-495 in pre-eclampsia diagnosis and evaluation. , 2018, Archives of biochemistry and biophysics.

[30]  Dong Li,et al.  Exosomes Derived From miR-133b-Modified Mesenchymal Stem Cells Promote Recovery After Spinal Cord Injury , 2018, Front. Neurosci..

[31]  H. Baharvand,et al.  Interaction between mesenchymal stromal cell‐derived extracellular vesicles and immune cells by distinct protein content , 2018, Journal of cellular physiology.

[32]  Xuemei Chen,et al.  Mesenchymal Stem Cell-Derived Exosomes Reduce A1 Astrocytes via Downregulation of Phosphorylated NFκB P65 Subunit in Spinal Cord Injury , 2018, Cellular Physiology and Biochemistry.

[33]  Songou Zhang,et al.  Inhibition of NF-κB Signaling Pathway by Resveratrol Improves Spinal Cord Injury , 2018, Front. Neurosci..

[34]  B. Tang.  Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers , 2018, Brain Research Bulletin.

[35]  P. Soon-Shiong,et al.  Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells-derived exosomes , 2018, Scientific Reports.

[36]  C. Bai,et al.  Lung-Resident Mesenchymal Stem Cells Promote Repair of LPS-Induced Acute Lung Injury via Regulating the Balance of Regulatory T cells and Th17 cells , 2018, Inflammation.

[37]  Renwen Zhang,et al.  hucMSC derived exosomes promote functional recovery in spinal cord injury mice via attenuating inflammation. , 2018, Materials science & engineering. C, Materials for biological applications.

[38]  Haibin Dai,et al.  Complement Component C3 Promotes Cerebral Ischemia/Reperfusion Injury Mediated by TLR2/NFκB Activation in Diabetic Mice , 2018, Neurochemical Research.

[39]  J. Silver,et al.  The Biology of Regeneration Failure and Success After Spinal Cord Injury. , 2018, Physiological reviews.

[40]  Q. Han,et al.  Exosomes Derived from Hypoxia-Treated Human Adipose Mesenchymal Stem Cells Enhance Angiogenesis Through the PKA Signaling Pathway. , 2018, Stem cells and development.

[41]  R. Ramasamy,et al.  Characterisation and immunosuppressive activity of human cartilage-derived mesenchymal stem cells , 2018, Cytotechnology.

[42]  S. Okada,et al.  Astrocyte reactivity and astrogliosis after spinal cord injury , 2018, Neuroscience Research.

[43]  S. Neelamegham,et al.  The microRNA regulatory landscape of MSC-derived exosomes: a systems view , 2018, Scientific Reports.

[44]  J. Kocsis,et al.  Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord , 2018, PloS one.

[45]  M. Stojkovic,et al.  Ethical and Safety Issues of Stem Cell-Based Therapy , 2018, International journal of medical sciences.

[46]  Xuyang,et al.  Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Attenuates Apoptosis, Inflammation, and Promotes Angiogenesis after Spinal Cord Injury in Rats. , 2017 .

[47]  Yinghua Zou,et al.  Efficient Differentiation of Bone Marrow Mesenchymal Stem Cells into Endothelial Cells in Vitro. , 2017, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[48]  Jian-kun Yang,et al.  Comprehensive proteomics analysis of exosomes derived from human seminal plasma , 2017, Andrology.

[49]  M. Fürthauer,et al.  Biogenesis and function of ESCRT-dependent extracellular vesicles. , 2017, Seminars in cell & developmental biology.

[50]  I. Han,et al.  Propitious Therapeutic Modulators to Prevent Blood-Spinal Cord Barrier Disruption in Spinal Cord Injury , 2017, Molecular Neurobiology.

[51]  B. Barres,et al.  Reactive Astrocytes: Production, Function, and Therapeutic Potential. , 2017, Immunity.

[52]  A. Villa,et al.  Soluble Factors on Stage to Direct Mesenchymal Stem Cells Fate , 2017, Front. Bioeng. Biotechnol..

[53]  M. Chopp,et al.  Exosomes Derived from Mesenchymal Stromal Cells Promote Axonal Growth of Cortical Neurons , 2016, Molecular Neurobiology.

[54]  Jing Wang,et al.  Isolation and Identification of miRNAs in exosomes derived from serum of colon cancer patients , 2017, Journal of Cancer.

[55]  M. Pittenger,et al.  Concise Review: MSC‐Derived Exosomes for Cell‐Free Therapy , 2017, Stem cells.

[56]  K. Ha,et al.  Spinal Cord Injury and Related Clinical Trials , 2017, Clinics in orthopedic surgery.

[57]  Manoj Kumar,et al.  INGE GRUNDKE-IQBAL AWARD FOR ALZHEIMER’S RESEARCH: NEUROTOXIC REACTIVE ASTROCYTES ARE INDUCED BY ACTIVATED MICROGLIA , 2019, Alzheimer's & Dementia.

[58]  Hongyu Zhang,et al.  The cross-talk between autophagy and endoplasmic reticulum stress in blood-spinal cord barrier disruption after spinal cord injury , 2016, Oncotarget.

[59]  Ji Hu,et al.  Targeting the blood-spinal cord barrier: A therapeutic approach to spinal cord protection against ischemia-reperfusion injury. , 2016, Life sciences.

[60]  Ji Hu,et al.  Advance in spinal cord ischemia reperfusion injury: Blood-spinal cord barrier and remote ischemic preconditioning. , 2016, Life sciences.

[61]  Q. Han,et al.  Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a , 2016, Journal of Cell Science.

[62]  U. Wyneken,et al.  Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche , 2016, Stem cells international.

[63]  A. Eid,et al.  Inflammogenesis of Secondary Spinal Cord Injury , 2016, Front. Cell. Neurosci..

[64]  Yan Ao,et al.  Astrocyte scar formation aids central nervous system axon regeneration , 2016, Nature.

[65]  A. de Becker,et al.  Homing and migration of mesenchymal stromal cells: How to improve the efficacy of cell therapy? , 2016, World journal of stem cells.

[66]  A. Khvorova,et al.  High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources , 2016, Journal of extracellular vesicles.

[67]  Liangpeng Li,et al.  How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart? , 2015, Stem cells international.

[68]  J. S. Heo,et al.  Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue , 2015, International journal of molecular medicine.

[69]  D. Guo,et al.  Bone marrow-derived mesenchymal stem cells suppress NK cell recruitment and activation in PolyI:C-induced liver injury. , 2015, Biochemical and biophysical research communications.

[70]  H. Niessen,et al.  Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species , 2015, Stem Cell Research & Therapy.

[71]  J. Meldolesi,et al.  Ectosomes and exosomes: shedding the confusion between extracellular vesicles. , 2015, Trends in cell biology.

[72]  De-Cheng Wu,et al.  Mesenchymal stem cells attenuated PLGA-induced inflammatory responses by inhibiting host DC maturation and function. , 2015, Biomaterials.

[73]  Changqing Zhang,et al.  Exosomes secreted by human-induced pluripotent stem cell-derived mesenchymal stem cells attenuate limb ischemia by promoting angiogenesis in mice , 2015, Stem Cell Research & Therapy.

[74]  Sha Li,et al.  Exosome and Exosomal MicroRNA: Trafficking, Sorting, and Function , 2015, Genom. Proteom. Bioinform..

[75]  L. Yazmalar,et al.  Rehabilitation of spinal cord injuries. , 2015, World journal of orthopedics.

[76]  M. Grãos,et al.  Differentiation of Human Umbilical Cord Matrix Mesenchymal Stem Cells into Neural-Like Progenitor Cells and Maturation into an Oligodendroglial-Like Lineage , 2014, PloS one.

[77]  C. Théry,et al.  Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. , 2014, Annual review of cell and developmental biology.

[78]  R. Bordet,et al.  The role of hemorrhage following spinal-cord injury , 2014, Brain Research.

[79]  A. Salgado,et al.  From basics to clinical: A comprehensive review on spinal cord injury , 2014, Progress in Neurobiology.

[80]  Hongcan Shi,et al.  Comparisons of Rabbit Bone Marrow Mesenchymal Stem Cell Isolation and Culture Methods In Vitro , 2014, PloS one.

[81]  L. Chamley,et al.  Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages , 2013, Stem Cell Reviews and Reports.

[82]  S. Lim,et al.  Mesenchymal stem cell: an efficient mass producer of exosomes for drug delivery. , 2013, Advanced drug delivery reviews.

[83]  M. Oudega.  Molecular and cellular mechanisms underlying the role of blood vessels in spinal cord injury and repair , 2012, Cell and Tissue Research.

[84]  M. Soleimani,et al.  Genetic modification of mesenchymal stem cells to overexpress CXCR4 and CXCR7 does not improve the homing and therapeutic potentials of these cells in experimental acute kidney injury. , 2012, Stem cells and development.

[85]  M. Stewart,et al.  Mesenchymal stem cells: characteristics, sources, and mechanisms of action. , 2011, The Veterinary clinics of North America. Equine practice.

[86]  Scott D Emr,et al.  The ESCRT pathway. , 2011, Developmental cell.

[87]  S. David,et al.  Repertoire of microglial and macrophage responses after spinal cord injury , 2011, Nature Reviews Neuroscience.

[88]  J. Kessler,et al.  Stem cell therapies for spinal cord injury , 2010, Nature Reviews Neurology.

[89]  Zhigang He,et al.  Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway , 2008, Science.

[90]  O. Koç,et al.  Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells. , 2005, Experimental hematology.

[91]  C. Cotman,et al.  Activation of complement pathways after contusion-induced spinal cord injury. , 2004, Journal of neurotrauma.

[92]  Jie Shen,et al.  Overexpression of CXCR7 promotes mesenchymal stem cells to repair phosgene-induced acute lung injury in rats. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[93]  E. Bieberich,et al.  Ceramide and Exosomes: A Novel Target in Cancer Biology and Therapy: CHAPTER FIVE , 2018, Advances in cancer research.

[94]  Duo Zhang,et al.  Enrichment of selective miRNAs in exosomes and delivery of exosomal miRNAs in vitro and in vivo. , 2017, American journal of physiology. Lung cellular and molecular physiology.

[95]  Rajarshi Pal,et al.  The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration. , 2016, Cytotherapy.

[96]  Lingyun Sun,et al.  Umbilical cord mesenchymal stem cells suppress B-cell proliferation and differentiation. , 2012, Cellular immunology.