Poly(ethylene glycol) (PEG)-lactic acid nanocarrier-based degradable hydrogels for restoring the vaginal microenvironment.

[1]  M. Einstein,et al.  Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive , 2012, PloS one.

[2]  Karyn G. Robinson,et al.  In situ crosslinkable heparin-containing poly(ethylene glycol) hydrogels for sustained anticoagulant release. , 2012, Journal of biomedical materials research. Part A.

[3]  S. Love,et al.  Influence of Molecular Size on the Retention of Polymeric Nanocarrier Diagnostic Agents in Breast Ducts , 2012, Pharmaceutical Research.

[4]  J. Remon,et al.  Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging. , 2012, International journal of pharmaceutics.

[5]  R. Cone,et al.  In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide , 2011, BMC infectious diseases.

[6]  M. Chikindas,et al.  The aetiology of bacterial vaginosis , 2011, Journal of applied microbiology.

[7]  Taha Taha,et al.  Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women , 2011, AIDS.

[8]  P. Sinko,et al.  Doxycycline hydrogels with reversible disulfide crosslinks for dermal wound healing of mustard injuries. , 2011, Biomaterials.

[9]  S. Witkin,et al.  Contemporary perspectives on vaginal pH and lactobacilli. , 2011, American journal of obstetrics and gynecology.

[10]  J. Pudney,et al.  Development of an in vitro alternative assay method for vaginal irritation. , 2011, Toxicology.

[11]  Thomas J. Smith,et al.  Advances in microbicide vaginal rings. , 2010, Antiviral research.

[12]  S. McCormack,et al.  The last decade of microbicide clinical trials in Africa: from hypothesis to facts , 2010, AIDS.

[13]  Lynn Morris,et al.  Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women , 2010, Science.

[14]  J. Nuttall,et al.  Microbicides in the Prevention of HIV Infection , 2010, Drugs.

[15]  A. Servin,et al.  Individual and co-operative roles of lactic acid and hydrogen peroxide in the killing activity of enteric strain Lactobacillus johnsonii NCC933 and vaginal strain Lactobacillus gasseri KS120.1 against enteric, uropathogenic and vaginosis-associated pathogens. , 2010, FEMS microbiology letters.

[16]  L. van Damme,et al.  Results of a safety and feasibility study of the diaphragm used with ACIDFORM Gel or K-Y Jelly. , 2010, Contraception.

[17]  P. Sinko,et al.  Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds. , 2010, Biomaterials.

[18]  S. Kannan,et al.  Drug release characteristics of PAMAM dendrimer-drug conjugates with different linkers. , 2010, International journal of pharmaceutics.

[19]  P. Mastromarino,et al.  Inhibition of herpes simplex virus type 2 by vaginal lactobacilli. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[20]  T. Hope,et al.  Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus , 2009, Journal of Virology.

[21]  P. Sinko,et al.  Design and evaluation of novel fast forming pilocarpine-loaded ocular hydrogels for sustained pharmacological response. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[22]  R. Mumper,et al.  Formulating a Sulfonated Antiviral Dendrimer in a Vaginal Microbicidal Gel Having Dual Mechanisms of Action , 2009, Drug development and industrial pharmacy.

[23]  C. Dezzutti,et al.  Targeted Delivery of PSC-RANTES for HIV-1 Prevention using Biodegradable Nanoparticles , 2009, Pharmaceutical Research.

[24]  B. Friedland,et al.  Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial , 2008, The Lancet.

[25]  J. Justman,et al.  Vaginal microbicides and the prevention of HIV transmission. , 2008, The Lancet. Infectious diseases.

[26]  A. Adimora,et al.  Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies , 2008, AIDS.

[27]  J. H. van de Wijgert,et al.  Vaginal microbicides: the importance of effective distribution, retention and coating of the mucosa. , 2008, AIDS.

[28]  K. Barnhart,et al.  Contraceptive Efficacy of a Novel Spermicidal Microbicide Used With a Diaphragm: A Randomized Controlled Trial , 2007, Obstetrics and gynecology.

[29]  L. Grohskopf,et al.  Preclinical Testing of Candidate Topical Microbicides for Anti-Human Immunodeficiency Virus Type 1 Activity and Tissue Toxicity in a Human Cervical Explant Culture , 2007, Antimicrobial Agents and Chemotherapy.

[30]  C. Tsakiroglou,et al.  Liposomal drugs dispersed in hydrogels. Effect of liposome, drug and gel properties on drug release kinetics. , 2007, Colloids and surfaces. B, Biointerfaces.

[31]  D. Katz,et al.  Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles. , 2007, Journal of pharmaceutical sciences.

[32]  Sarah L. Kieweg,et al.  Biophysical analysis of prototype microbicidal gels. , 2007, Journal of pharmaceutical sciences.

[33]  A. Woolfson,et al.  Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide. , 2006, International journal of pharmaceutics.

[34]  Robert A. Anderson,et al.  ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations. , 2006, The Journal of infectious diseases.

[35]  R. Cone,et al.  Vaginal microbicides: detecting toxicities in vivo that paradoxically increase pathogen transmission , 2006, BMC infectious diseases.

[36]  F. Petraglia,et al.  [Effectiveness of oral administration of Lactobacillus paracasei subsp. paracasei F19 in association with vaginal suppositories of Lactobacillus acidofilus in the treatment of vaginosis and in the prevention of recurrent vaginitis]. , 2006, Minerva ginecologica.

[37]  Sally Freeman,et al.  Synthesis, characterization and stability of dendrimer prodrugs. , 2006, International journal of pharmaceutics.

[38]  H. Maeda,et al.  The EPR Effect and Polymeric Drugs: A Paradigm Shift for Cancer Chemotherapy in the 21st Century , 2005 .

[39]  A. Woolfson,et al.  Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings. , 2005, The Journal of antimicrobial chemotherapy.

[40]  K. Barnhart,et al.  In vivo distribution of a vaginal gel: MRI evaluation of the effects of gel volume, time and simulated intercourse. , 2004, Contraception.

[41]  M. Nader-Macías,et al.  Growth and lactic acid production by vaginal Lactobacillus acidophilus CRL 1259, and inhibition of uropathogenic Escherichia coli. , 2003, Journal of medical microbiology.

[42]  Christina H. Park,et al.  Antimicrobial components of vaginal fluid. , 2002, American journal of obstetrics and gynecology.

[43]  F. Krebs,et al.  Comparative In Vitro Sensitivities of Human Immune Cell Lines, Vaginal and Cervical Epithelial Cell Lines, and Primary Cells to Candidate Microbicides Nonoxynol 9, C31G, and Sodium Dodecyl Sulfate , 2002, Antimicrobial Agents and Chemotherapy.

[44]  R. Langer,et al.  Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications , 2002, Science.

[45]  K. Whaley,et al.  Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. , 2001, Human reproduction.

[46]  Robert A. Anderson,et al.  Properties of a new acid-buffering bioadhesive vaginal formulation (ACIDFORM). , 2001, Contraception.

[47]  J. Peipert,et al.  Safety and tolerability of BufferGel, a novel vaginal microbicide, in women in the United States. , 2001, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[48]  B. Chohan,et al.  Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. , 1999, The Journal of infectious diseases.

[49]  K. Whaley,et al.  Acid Production by Vaginal Flora In Vitro Is Consistent with the Rate and Extent of Vaginal Acidification , 1999, Infection and Immunity.

[50]  D R Hoover,et al.  Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV , 1998, AIDS.

[51]  D. Taylor-Robinson,et al.  Safety study of nonoxynol-9 as a vaginal microbicide: evidence of adverse effects. , 1998, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

[52]  N. Sewankambo,et al.  HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis , 1997, The Lancet.

[53]  J. Humphries,et al.  Spreading and Retention of Vaginal Formulations in Post-Menopausal Women as Assessed by Gamma Scintigraphy , 1997, Pharmaceutical Research.

[54]  K. Nelson,et al.  Bacterial vaginosis and HIV seroprevalence among female commercial sex workers in Chiang Mai, Thailand , 1995, AIDS.

[55]  S. Hillier Diagnostic microbiology of bacterial vaginosis. , 1993, American journal of obstetrics and gynecology.

[56]  W. Lang Vaginal acidity and pH; a review. , 1955, Obstetrical & gynecological survey.

[57]  M. P. Gonçalves,et al.  Rheological properties of vaginal hydrophilic polymer gels. , 2009, Current drug delivery.

[58]  M. Falagas,et al.  Probiotics for the treatment of women with bacterial vaginosis , 2007 .

[59]  Prashini Moodley,et al.  Interrelationships among human immunodeficiency virus type 1 infection, bacterial vaginosis, trichomoniasis, and the presence of yeasts. , 2002, The Journal of infectious diseases.

[60]  K. Whaley,et al.  Boskey, E.R., Cone, R.A., Whaley, K.J. & Moench, T.R. Origins of vaginal acidity: high D/L lactate ratio is consistent with bacteria being the primary source. Hum. Reprod. 16, 1809-1813 , 2001 .

[61]  Ş. Tavukçuoǧlu,et al.  Alternative treatment for bacterial vaginosis in pregnant patients; restoration of vaginal acidity and flora. , 1996, Archives of AIDS research.

[62]  D. Lindell,et al.  Bacterial vaginosis and the effect of intermittent prophylactic treatment with an acid lactate gel. , 1990, Gynecologic and obstetric investigation.