Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α.
暂无分享,去创建一个
Bruce J. Melancon | B. LaFleur | A. Waterson | Ethan Lee | A. Salic | Laura A. Lee | Emilios Tahinci | C. Thorne | Kristin K. Jernigan | G. Sulikowski | Alison J. Hanson | A. Hanson | Christopher S. Cselenyi | Kelly C Meyers | D. Orton | David M. Miller | J. Schneider | Kwangho Kim | Brian I Hang | Victor P. Ghidu | B. Melancon
[1] A. Burgess,et al. Restoration of full-length adenomatous polyposis coli (APC) protein in a colon cancer cell line enhances cell adhesion , 2003, Journal of Cell Science.
[2] J. Nunez,et al. Multisite phosphorylation of tau proteins from rat brain. , 1983, Biochemical and biophysical research communications.
[3] O. Huber,et al. A second protein kinase CK1-mediated step negatively regulates Wnt signalling by disrupting the lymphocyte enhancer factor-1/β-catenin complex , 2005, Cellular and Molecular Life Sciences.
[4] M. Kirschner,et al. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. , 2000, Molecular cell.
[5] Ming You,et al. TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth , 2006, Cell.
[6] Bert Vogelstein,et al. Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer , 1998 .
[7] E. D. De Robertis,et al. Dorsal-ventral patterning and neural induction in Xenopus embryos. , 2004, Annual review of cell and developmental biology.
[8] Kendra S. Burbank,et al. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles , 2004, The Journal of cell biology.
[9] Hendrik C Korswagen,et al. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. , 2002, Genes & development.
[10] J. Nathans,et al. Vascular Development in the Retina and Inner Ear Control by Norrin and Frizzled-4, a High-Affinity Ligand-Receptor Pair , 2004, Cell.
[11] C. Larabell,et al. Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling Pathway , 1997, The Journal of cell biology.
[12] Lawrence Lum,et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer , 2008, Nature chemical biology.
[13] Andreas Gocht,et al. The casein kinase 1 family: participation in multiple cellular processes in eukaryotes. , 2005, Cellular signalling.
[14] Xi He,et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. , 2002, Cell.
[15] J. Nunez,et al. Multisite phosphorylation of τ proteins from rat brain , 1983 .
[16] H. Esumi,et al. Antitumor activity of pyrvinium pamoate, 6‐(dimethylamino)‐2‐[2‐(2,5‐dimethyl‐1‐phenyl‐1H‐pyrrol‐3‐yl)ethenyl]‐1‐methyl‐quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation , 2004, Cancer science.
[17] Jeremy Nathans,et al. A new member of the frizzled family from Drosophila functions as a Wingless receptor , 1996, Nature.
[18] Xi He,et al. Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism , 2002, Cell.
[19] M. Price,et al. CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. , 2006, Genes & development.
[20] J. Whangbo,et al. A Wnt signaling system that specifies two patterns of cell migration in C. elegans. , 1999, Molecular cell.
[21] J. Lewis,et al. The genetics of levamisole resistance in the nematode Caenorhabditis elegans. , 1980, Genetics.
[22] Hans Clevers,et al. Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors , 2002, Molecular and Cellular Biology.
[23] C. Slaughter,et al. ERK phosphorylation potentiates Elk‐1‐mediated ternary complex formation and transactivation. , 1995, The EMBO journal.
[24] A. Sparks,et al. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. , 1998, Cancer research.
[25] C. Chong,et al. Efficacy of Pyrvinium Pamoate against Cryptosporidium parvum Infection In Vitro and in a Neonatal Mouse Model , 2008, Antimicrobial Agents and Chemotherapy.
[26] David S. Parker,et al. Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila. , 2002, Development.
[27] E. Hempelmann. Hemozoin Biocrystallization in Plasmodium falciparum and the antimalarial activity of crystallization inhibitors , 2007, Parasitology Research.
[28] Eric Wieschaus,et al. Wg/Wnt signal can be transmitted through arrow/LRP5,6 and Axin independently of Zw3/Gsk3beta activity. , 2003, Developmental cell.
[29] M. Bienz,et al. The function of BCL9 in Wnt/β-catenin signaling and colorectal cancer cells , 2008, BMC Cancer.
[30] Hans Clevers,et al. Mining the Wnt pathway for cancer therapeutics , 2007, Nature Reviews Drug Discovery.
[31] P. Vogt,et al. Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[32] Marc W. Kirschner,et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling , 2009, Nature.
[33] C. Larabell. Establishment of the dorsoventral axis in Xenopus embryos is presaged by early asymmetries in β-catenin that are modulated by the Wnt signaling pathway , 1997 .
[34] P. Polakis. Wnt signaling and cancer. , 2000, Genes & development.
[35] H. Korswagen,et al. Activation of Wnt signaling bypasses the requirement for RTK/Ras signaling during C. elegans vulval induction. , 2002, Genes & development.
[36] J. Pietenpol,et al. A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73 , 2008, Molecular and Cellular Biology.
[37] Hideki Yamamoto,et al. Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability* , 1999, The Journal of Biological Chemistry.
[38] M. Boothby,et al. Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[39] Sandipan Chatterjee,et al. Wnt/wingless Signaling Requires Bcl9/legless-mediated Recruitment of Pygopus to the Nuclear Beta-catenin-tcf Complex , 2022 .
[40] D. Virshup,et al. Casein kinase I phosphorylates and destabilizes the β-catenin degradation complex , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[41] Kevan M Shokat,et al. Features of selective kinase inhibitors. , 2005, Chemistry & biology.
[42] Jun Zhang,et al. Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival , 2009, Nature.
[43] H. Clevers. Wnt/beta-catenin signaling in development and disease. , 2006, Cell.
[44] B. Hann,et al. Non-competitive androgen receptor inhibition in vitro and in vivo , 2009, Proceedings of the National Academy of Sciences.
[45] A. Sparks,et al. Identification of c-MYC as a target of the APC pathway. , 1998, Science.
[46] Ethan Lee,et al. LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin , 2008, Proceedings of the National Academy of Sciences of the United States of America.
[47] D. Houston,et al. Wnt11/β-catenin signaling in both oocytes and early embryos acts through LRP6-mediated regulation of axin , 2006, Development.
[48] F. Matschinsky,et al. Assessing the potential of glucokinase activators in diabetes therapy , 2009, Nature Reviews Drug Discovery.
[49] Mariann Bienz,et al. A new nuclear component of the Wnt signalling pathway , 2002, Nature Cell Biology.
[50] W. Birchmeier,et al. Wnt signalling and its impact on development and cancer , 2008, Nature Reviews Cancer.
[51] Choun-Ki Joo,et al. Wnt/β-Catenin/Tcf Signaling Induces the Transcription of Axin2, a Negative Regulator of the Signaling Pathway , 2002, Molecular and Cellular Biology.
[52] S. Altschul,et al. Identification of FAP locus genes from chromosome 5q21. , 1991, Science.
[53] Timothy H. Davis,et al. Pyrvinium Targets the Unfolded Protein Response to Hypoglycemia and Its Anti-Tumor Activity Is Enhanced by Combination Therapy , 2008, PloS one.
[54] R. Whitehead,et al. Smad3 has a critical role in TGF-beta-mediated growth inhibition and apoptosis in colonic epithelial cells. , 2004, The Journal of surgical research.