Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates

[1]  坂平 英樹 Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis , 2000 .

[2]  Y Maru [Tumor progression and angiogenesis]. , 1999, Gan to kagaku ryoho. Cancer & chemotherapy.

[3]  J. Velier,et al.  Caspase-8 and Caspase-3 Are Expressed by Different Populations of Cortical Neurons Undergoing Delayed Cell Death after Focal Stroke in the Rat , 1999, The Journal of Neuroscience.

[4]  R. Virmani,et al.  Apoptosis in heart failure: release of cytochrome c from mitochondria and activation of caspase-3 in human cardiomyopathy. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[5]  土屋 勝裕 Postictal blockade of ischemic hippocampal neuronal death in primates using selective cathepsin inhibitors , 1999 .

[6]  Jin-Moo Lee,et al.  The changing landscape of ischaemic brain injury mechanisms , 1999, Nature.

[7]  G. Robertson,et al.  Attenuation of Ischemia-Induced Cellular and Behavioral Deficits by X Chromosome-Linked Inhibitor of Apoptosis Protein Overexpression in the Rat Hippocampus , 1999, The Journal of Neuroscience.

[8]  G. Sutherland,et al.  Electron Microscopic Evidence against Apoptosis as the Mechanism of Neuronal Death in Global Ischemia , 1999, The Journal of Neuroscience.

[9]  L. Ellerby,et al.  Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[10]  C J Epstein,et al.  Manganese Superoxide Dismutase Mediates the Early Release of Mitochondrial Cytochrome C and Subsequent DNA Fragmentation after Permanent Focal Cerebral Ischemia in Mice , 1999, The Journal of Neuroscience.

[11]  L Manzo,et al.  Neuronal cell death: a demise with different shapes. , 1999, Trends in pharmacological sciences.

[12]  P. Nicotera,et al.  Execution of Apoptosis: Converging or Diverging Pathways? , 1999, Biological chemistry.

[13]  木村 麗新 The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas , 1999 .

[14]  Sten Orrenius,et al.  Cleavage of the calpain inhibitor, calpastatin, during apoptosis , 1998, Cell Death and Differentiation.

[15]  D. Green,et al.  Calpain activation is upstream of caspases in radiation-induced apoptosis , 1998, Cell Death and Differentiation.

[16]  S. Nagata,et al.  Caspase-independent Cell Killing by Fas-associated Protein with Death Domain , 1998, The Journal of cell biology.

[17]  W. Fiers,et al.  Atractyloside‐induced release of cathepsin B, a protease with caspase‐processing activity , 1998, FEBS letters.

[18]  C. Epstein,et al.  Overexpression of SOD1 in Transgenic Rats Protects Vulnerable Neurons Against Ischemic Damage After Global Cerebral Ischemia and Reperfusion , 1998, The Journal of Neuroscience.

[19]  T. Utsumi,et al.  Activation of caspase‐3‐like protease by digitonin‐treated lysosomes , 1998, FEBS letters.

[20]  C. Barbato,et al.  Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing Apoptosis , 1998, The Journal of Neuroscience.

[21]  M. Barinaga Stroke-Damaged Neurons May Commit Cellular Suicide , 1998, Science.

[22]  K. Wang,et al.  Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis. , 1998, Archives of biochemistry and biophysics.

[23]  J. Inazawa,et al.  Molecular cloning and characterization of human caspase-activated DNase. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[24]  B. Pike,et al.  Regional calpain and caspase‐3 proteolysis of α‐spectrin after traumatic brain injury , 1998, Neuroreport.

[25]  M. Nakao,et al.  The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas , 1998, Nature Medicine.

[26]  Carlos Portera-Cailliau,et al.  Neurodegeneration in Excitotoxicity, Global Cerebral Ischemia, and Target Deprivation: A Perspective on the Contributions of Apoptosis and Necrosis , 1998, Brain Research Bulletin.

[27]  R. Simon,et al.  Induction of Caspase-3-Like Protease May Mediate Delayed Neuronal Death in the Hippocampus after Transient Cerebral Ischemia , 1998, The Journal of Neuroscience.

[28]  Y. Uchiyama,et al.  Detection of activated Caspase-3 by a cleavage site-directed antiserum during naturally occurring DRG neurons apoptosis. , 1998, Biochemical and biophysical research communications.

[29]  B. Pike,et al.  Temporal relationships between de novo protein synthesis, calpain and caspase 3‐like protease activation, and DNA fragmentation during apoptosis in septo‐hippocampal cultures , 1998, Journal of neuroscience research.

[30]  M. Moskowitz,et al.  Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia , 1998, The Journal of Neuroscience.

[31]  T. Yamashima,et al.  Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA‐074: a novel strategy for neuroprotection based on ‘calpain–cathepsin hypothesis’ , 1998 .

[32]  K. Öllinger,et al.  Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. , 1998, The American journal of pathology.

[33]  C. Lemaire,et al.  Inhibition of caspase activity induces a switch from apoptosis to necrosis , 1998, FEBS letters.

[34]  B. Pettmann,et al.  Calpain inhibitors, but not caspase inhibitors, prevent actin proteolysis and DNA fragmentation during apoptosis. , 1998, Journal of cell science.

[35]  Dale Corbett,et al.  The problem of assessing effective neuroprotection in experimental cerebral ischemia , 1998, Progress in Neurobiology.

[36]  S. Paul,et al.  Transient Global Forebrain Ischemia Induces a Prolonged Expression of the Caspase-3 mRNA in Rat Hippocampal CA1 Pyramidal Neurons , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[37]  M. Moskowitz,et al.  Attenuation of Delayed Neuronal Death after Mild Focal Ischemia in Mice by Inhibition of the Caspase Family , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[38]  J. B. Hutchins,et al.  Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction , 1998, The Journal of Neuroscience.

[39]  S. Nagata,et al.  A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD , 1998, Nature.

[40]  Makoto Kawase,et al.  Mitochondrial Susceptibility to Oxidative Stress Exacerbates Cerebral Infarction That Follows Permanent Focal Cerebral Ischemia in Mutant Mice with Manganese Superoxide Dismutase Deficiency , 1998, The Journal of Neuroscience.

[41]  M. Linnik,et al.  Six-hour window of opportunity for calpain inhibition in focal cerebral ischemia in rats. , 1998, Stroke.

[42]  D. Green,et al.  Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD‐specific caspase activation and independently of mitochondrial transmembrane depolarization , 1998, The EMBO journal.

[43]  K. Suzuki,et al.  Structure and physiological function of calpains. , 1997, The Biochemical journal.

[44]  John Calvin Reed,et al.  The c‐IAP‐1 and c‐IAP‐2 proteins are direct inhibitors of specific caspases , 1997, The EMBO journal.

[45]  S. Srinivasula,et al.  Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade , 1997, Cell.

[46]  Yung-Hyun Choi,et al.  Regulation of Cyclin D1 by Calpain Protease* , 1997, The Journal of Biological Chemistry.

[47]  P. Nicotera,et al.  Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide , 1997, Molecular medicine.

[48]  T. Saido,et al.  Downregulation of calpastatin in rat heart after brief ischemia and reperfusion. , 1997, Journal of Biochemistry (Tokyo).

[49]  S. Korsmeyer,et al.  Errors of homeostasis and deregulated apoptosis. , 1997, Current opinion in genetics & development.

[50]  A. Yakovlev,et al.  Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury , 1997, The Journal of Neuroscience.

[51]  P. Blackshear,et al.  Identification and Characterization of Cathepsin B as the Cellular MARCKS Cleaving Enzyme* , 1997, The Journal of Biological Chemistry.

[52]  S. Orrenius,et al.  Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis , 1997, FEBS letters.

[53]  G. Robertson,et al.  Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus , 1997, Nature Medicine.

[54]  G M Cohen,et al.  Caspases: the executioners of apoptosis. , 1997, The Biochemical journal.

[55]  Xiaodong Wang,et al.  Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 , 1997, Cell.

[56]  M. Linnik,et al.  Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[57]  N. Thornberry,et al.  Caspases: killer proteases. , 1997, Trends in biochemical sciences.

[58]  D. Altieri,et al.  A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma , 1997, Nature Medicine.

[59]  R. Weichselbaum,et al.  Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[60]  G. Lynch,et al.  Suppression of Cathepsins B and L Causes a Proliferation of Lysosomes and the Formation of Meganeurites in Hippocampus , 1997, The Journal of Neuroscience.

[61]  T. Saido,et al.  Up- and down-regulation of calpain inhibitor polypeptide, calpastatin, in postischemic hippocampus , 1997, Neuroscience Letters.

[62]  Y. Tsujimoto,et al.  Intracellular ATP levels determine cell death fate by apoptosis or necrosis. , 1997, Cancer research.

[63]  Xiaodong Wang,et al.  DFF, a Heterodimeric Protein That Functions Downstream of Caspase-3 to Trigger DNA Fragmentation during Apoptosis , 1997, Cell.

[64]  U. Tuor,et al.  Detection of Higher-Order 50- and 10-kbp DNA Fragments before Apoptotic Internucleosomal Cleavage after Transient Cerebral Ischemia , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[65]  T. Tsuruo,et al.  Actin cleavage by CPP-32/apopain during the development of apoptosis , 1997, Oncogene.

[66]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[67]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[68]  W. Fiers,et al.  Characterization of seven murine caspase family members , 1997, FEBS letters.

[69]  E. Alnemri,et al.  Resistance of actin to cleavage during apoptosis. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[70]  N. Imamoto,et al.  Essential role of active nuclear transport in apoptosis , 1997, Genes to cells : devoted to molecular & cellular mechanisms.

[71]  M. Kubbutat,et al.  Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability , 1997, Molecular and cellular biology.

[72]  E. Alnemri Mammalian cell death proteases: A family of highly conserved aspartate specific cysteine proteases , 1997, Journal of cellular biochemistry.

[73]  C. Epstein,et al.  Edema formation exacerbates neurological and histological outcomes after focal cerebral ischemia in CuZn-superoxide dismutase gene knockout mutant mice. , 1997, Acta neurochirurgica. Supplement.

[74]  U. Brunk,et al.  Photo-oxidative disruption of lysosomal membranes causes apoptosis of cultured human fibroblasts. , 1997, Free radical biology & medicine.

[75]  H. Chapman,et al.  Emerging roles for cysteine proteases in human biology. , 1997, Annual review of physiology.

[76]  A. Nanji,et al.  Apoptosis and Necrosis , 1997, Alcohol health and research world.

[77]  Y. Akao,et al.  Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. , 1996, The American journal of physiology.

[78]  S. Ratnofsky,et al.  Proteolytic Activation of Protein Kinase C ␦ by an Ice/ced 3-like Protease Induces Characteristics of Apoptosis Materials and Methods , 1996 .

[79]  Keisuke Kuida,et al.  Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice , 1996, Nature.

[80]  T. Yamashima,et al.  Dynamic changes of cathepsins B and L expression in the monkey hippocampus after transient ischemia. , 1996, Biochemical and biophysical research communications.

[81]  F. Sharp,et al.  Global ischemia induces apoptosis-associated genes in hippocampus. , 1996, Brain research. Molecular brain research.

[82]  Junying Yuan,et al.  Human ICE/CED-3 Protease Nomenclature , 1996, Cell.

[83]  Zhiyong Han,et al.  DNA-dependent Protein Kinase Is a Target for a CPP32-like Apoptotic Protease* , 1996, The Journal of Biological Chemistry.

[84]  T. Deckwerth,et al.  Neuronal Death in Developmental Models: Possible Implications in Neuropathology , 1996, Brain pathology.

[85]  D. Choi,et al.  Ischemia-induced neuronal apoptosis , 1996, Current Opinion in Neurobiology.

[86]  M. Takita,et al.  Transient Brain Ischaemia Provokes Ca2+, PIP2 and Calpain Responses Prior to Delayed Neuronal Death in Monkeys , 1996, The European journal of neuroscience.

[87]  John Calvin Reed,et al.  Altered expression of Bcl-2, Bcl-X, Bax, and c-Fos colocalizes with DNA fragmentation and ischemic cell damage following middle cerebral artery occlusion in rats. , 1996, Brain Research. Molecular Brain Research.

[88]  Xiaodong Wang,et al.  Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c , 1996, Cell.

[89]  Y. Tsujimoto,et al.  Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors. , 1996, Oncogene.

[90]  R. Simon,et al.  Expression of the Apoptosis‐Effector Gene, Bax, Is Up‐Regulated in Vulnerable Hippocampal CA1 Neurons Following Global Ischemia , 1996, Journal of neurochemistry.

[91]  E. Lunney,et al.  An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[92]  Y. Tsujimoto,et al.  Bcl-2 expression prevents activation of the ICE protease cascade. , 1996, Oncogene.

[93]  C. Thompson,et al.  A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. , 1996, The EMBO journal.

[94]  P. Chan,et al.  Role of oxidants in ischemic brain damage. , 1996, Stroke.

[95]  U. Aebi,et al.  Toward the molecular dissection of protein import into nuclei. , 1996, Current opinion in cell biology.

[96]  Y. Tsujimoto,et al.  Retardation of chemical hypoxia-induced necrotic cell death by Bcl-2 and ICE inhibitors: possible involvement of common mediators in apoptotic and necrotic signal transductions. , 1996, Oncogene.

[97]  D. Vaux,et al.  Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[98]  H. Horvitz,et al.  The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. , 1996, Genes & development.

[99]  Takuji Tanaka,et al.  Immunohistochemical detection of Bax and Bcl-2 proteins in gerbil hippocampus following transient forebrain ischemia , 1996, Brain Research.

[100]  X. Wang,et al.  Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. , 1996, The EMBO journal.

[101]  Y. Ben-Ari,et al.  Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[102]  D. Nicholson ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis , 1996, Nature Biotechnology.

[103]  C. Piantadosi,et al.  Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. , 1996, Stroke.

[104]  K. Tamai,et al.  Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes , 1996, Nature.

[105]  R. Nixon,et al.  Properties of the endosomal-lysosomal system in the human central nervous system: disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[106]  Bonnie F. Sloane,et al.  Tumor progression and angiogenesis: cathepsin B & Co. , 1996, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[107]  T. Ono,et al.  Ischemic neuronal damage specific to monkey hippocampus: Histological investigation , 1995, Brain Research Bulletin.

[108]  Mike Rothe,et al.  The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins , 1995, Cell.

[109]  Gerald M. Rubin,et al.  Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death , 1995, Cell.

[110]  D. Bredesen Neural apoptosis , 1995, Annals of neurology.

[111]  A. Rosen,et al.  DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis , 1995, The Journal of experimental medicine.

[112]  K. Öllinger,et al.  Cellular injury induced by oxidative stress is mediated through lysosomal damage. , 1995, Free radical biology & medicine.

[113]  K. Suzuki,et al.  Three distinct phases of fodrin proteolysis induced in postischemic hippocampus. Involvement of calpain and unidentified protease. , 1995, Stroke.

[114]  D. Choi,et al.  Blockade of glutamate receptors unmasks neuronal apoptosis after oxygen-glucose deprivation in vitro , 1995, Neuroscience.

[115]  S. Lipton,et al.  Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function , 1995, Neuron.

[116]  E. Preston,et al.  Differences in DNA Fragmentation following Transient Cerebral or Decapitation Ischemia in Rats , 1995, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[117]  R. Neumar,et al.  Eukaryotic Initiation Factor 4E Degradation During Brain Ischemia , 1995, Journal of neurochemistry.

[118]  S. Lipton,et al.  Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[119]  Patrick R. Griffin,et al.  Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis , 1995, Nature.

[120]  M. Chopp,et al.  Ultrastructural and light microscopic evidence of apoptosis after middle cerebral artery occlusion in the rat. , 1995, The American journal of pathology.

[121]  L. Benítez-Bribiesca [Apoptosis in the pathogenesis and treatment of disease]. , 1995, Gaceta medica de Mexico.

[122]  A. Hara,et al.  Temporal profile of nuclear DNA fragmentation in situ in gerbil hippocampus following transient forebrain ischemia , 1995, Brain Research.

[123]  Y. Uchiyama,et al.  Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[124]  J. H. Choi,et al.  Brain synaptosomal aging: free radicals and membrane fluidity. , 1995, Free radical biology & medicine.

[125]  T. Crawford,et al.  The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy , 1995, Cell.

[126]  N. Katunuma,et al.  Structure, properties, mechanisms, and assays of cysteine protease inhibitors: cystatins and E-64 derivatives. , 1995, Methods in enzymology.

[127]  F. Melchior,et al.  Mechanisms of nuclear protein import. , 1995, Current opinion in cell biology.

[128]  M. Takita,et al.  Temperature-dependent Ca2+ mobilization induced by hypoxia-hypoglycemia in the monkey hippocampal slices. , 1994, Biochemical and biophysical research communications.

[129]  E. Alnemri,et al.  CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. , 1994, The Journal of biological chemistry.

[130]  R. Bartus,et al.  Calpain Inhibitor AK295 Protects Neurons From Focal Brain Ischemia: Effects of Postocdusion Intra-arterial Administration , 1994, Stroke.

[131]  H. Horvitz,et al.  Programmed cell death in Caenorhabditis elegans. , 1994, Current opinion in genetics & development.

[132]  T. Shiraishi,et al.  Visualization of DNA double strand breaks in the gerbil hippocampal CA1 following transient ischemia , 1994, Neuroscience Letters.

[133]  R. Bartus,et al.  Postischemic Administration of AK275, a Calpain Inhibitor, Provides Substantial Protection against Focal Ischemic Brain Damage , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[134]  M. Pearson,et al.  The calpain cleavage sites in the epidermal growth factor receptor kinase domain. , 1994, European journal of biochemistry.

[135]  R. Siman,et al.  Immunolocalization of calpain I-mediated spectrin degradation to vulnerable neurons in the ischemic gerbil brain , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[136]  H. Nakanishi,et al.  Age-Related Changes in Activities and Localizations of Cathepsins D, E, B, and L in the Rat Brain Tissues , 1994, Experimental Neurology.

[137]  KEVIN S. Lee,et al.  Neuroprotection With a Calpain Inhibitor in a Model of Focal Cerebral Ischemia , 1994, Stroke.

[138]  P. H. Chan Oxygen Radicals in Focal Cerebral Ischemia , 1994, Brain pathology.

[139]  E. Preston,et al.  Global ischemia can cause DNA fragmentation indicative of apoptosis in rat brain , 1993, Neuroscience Letters.

[140]  K. Suzuki,et al.  Spatial resolution of fodrin proteolysis in postischemic brain. , 1993, The Journal of biological chemistry.

[141]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[142]  K. Mikoshiba,et al.  Internucleosomal DNA cleavage involved in ischemia-induced neuronal death. , 1993, Biochemical and biophysical research communications.

[143]  F. Watt,et al.  Specific cleavage of transcription factors by the thiol protease, m-calpain. , 1993, Nucleic acids research.

[144]  J. Coyle,et al.  Oxidative stress, glutamate, and neurodegenerative disorders. , 1993, Science.

[145]  H. Nakanishi,et al.  Transient Forebrain Ischemia Induces Increased Expression and Specific Localization of Cathepsins E and D in Rat Hippocampus and Neostriatum , 1993, Experimental Neurology.

[146]  R. Nixon,et al.  The Lysosomal System in Neuronal Cell Death: A Review a , 1993, Annals of the New York Academy of Sciences.

[147]  D. Warner Delayed neuronal death and delayed neuronal recovery in the human brain following global ischemia. , 1993 .

[148]  T. Deckwerth,et al.  Molecular mechanisms of developmental neuronal death. , 1993, Annual review of neuroscience.

[149]  R. Smith,et al.  Comparative behaviour of calpain and cathepsin B toward peptidyl acyloxymethyl ketones, sulphonium methyl ketones and other potential inhibitors of cysteine proteinases. , 1992, The Biochemical journal.

[150]  T. Ono,et al.  Hippocampal neuronal damage after transient forebrain ischemia in monkeys , 1992, Brain Research Bulletin.

[151]  Masahiko S. Satoh,et al.  Role of poly(ADP-ribose) formation in DNA repair , 1992, Nature.

[152]  K. Suzuki,et al.  Autolytic transition of mu-calpain upon activation as resolved by antibodies distinguishing between the pre- and post-autolysis forms. , 1992, Journal of biochemistry.

[153]  Lysosomal hydrolases of different classes are abnormally distributed in brains of patients with Alzheimer disease. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[154]  C. Epstein,et al.  Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[155]  A. Ivanov,et al.  Role of cAMP in regulation of activity of acid hydrolases of rat heart and liver during ischemia and after recirculation. , 1991, Resuscitation.

[156]  G. Lynch,et al.  Inhibition of proteolysis protects hippocampal neurons from ischemia. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[157]  G. Demartino,et al.  Calcium-activated neutral protease (calpain) system: structure, function, and regulation. , 1991, Physiological reviews.

[158]  M. Murata,et al.  Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro , 1991, FEBS letters.

[159]  N. Katunuma,et al.  Novel epoxysuccinyl peptides A selective inhibitor of cathepsin B, in vivo , 1991, FEBS letters.

[160]  山本 和己 Ultrastructural investigation of the CA1 region of the hippocampus after transient cerebral ischemia in gerbils , 1991 .

[161]  S. Mehdi,et al.  Cell-penetrating inhibitors of calpain. , 1991, Trends in biochemical sciences.

[162]  R Huber,et al.  The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity. , 1991, The EMBO journal.

[163]  H. Bernstein,et al.  Antigenic expression of cathepsin B in aged human brain , 1990, Brain Research Bulletin.

[164]  K. Wang Developing selective inhibitors of calpain. , 1990, Trends in pharmacological sciences.

[165]  K. Welch,et al.  Chronic cerebral intracellular alkalosis following forebrain ischemic insult in rats. , 1990, Stroke.

[166]  M. Takeda,et al.  Lysosome instability in aged rat brain , 1989, Neuroscience Letters.

[167]  H. Bernstein,et al.  Cathepsin B immunoreactive neurons in rat brain. A combined light and electron microscopic study. , 1989, Journal fur Hirnforschung.

[168]  F. Althaus,et al.  ADP-ribosylation of proteins. Enzymology and biological significance. , 2012, Molecular biology, biochemistry, and biophysics.

[169]  J. Carlson,et al.  Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat , 1987, Mechanisms of Ageing and Development.

[170]  K. Ichihara,et al.  Inhibition of ischemia-induced subcellular redistribution of lysosomal enzymes in the perfused rat heart by the calcium entry blocker, diltiazem. , 1987, The Journal of pharmacology and experimental therapeutics.

[171]  F. Plum,et al.  Delayed hippocampal damage in humans following cardiorespiratory arrest , 1987, Neurology.

[172]  Dr. Felix R. Althaus,et al.  ADP-Ribosylation of Proteins , 1987, Molecular Biology Biochemistry and Biophysics.

[173]  D. Amaral,et al.  Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus , 1996 .

[174]  M. A. Thomson,et al.  Temporal changes in hippocampal theta activity following twenty minutes of forebrain ischemia in the chronic rat , 1986, Brain Research.

[175]  N. Katunuma,et al.  Purification and tissue distribution of rat cathepsin L. , 1986, Journal of biochemistry.

[176]  H. Kontos George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury. , 1985, Circulation research.

[177]  T. Tsukahara,et al.  Distribution of cathepsins B and H in rat tissues and peripheral blood cells. , 1985, Journal of biochemistry.

[178]  T. Murachi Calcium-dependent proteinases and specific inhibitors: calpain and calpastatin. , 1984, Biochemical Society symposium.

[179]  Takaaki Kirino,et al.  Delayed neuronal death in the gerbil hippocampus following ischemia , 1982, Brain Research.

[180]  Fred Plum,et al.  Temporal profile of neuronal damage in a model of transient forebrain ischemia , 1982, Annals of neurology.

[181]  E. Shaw,et al.  Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases. , 1981, The Journal of biological chemistry.

[182]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.

[183]  J. Hinds,et al.  Aging in the rat olfactory bulb: Quantitative changes in mitral cell organelles and somato‐dendritic synapses , 1979, The Journal of comparative neurology.

[184]  M. Tamai,et al.  Isolation and Characterization of E–64, a New Thiol Protease Inhibitor , 1978 .

[185]  E. Cadenas,et al.  Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. , 1976, The Biochemical journal.

[186]  D. Bowen,et al.  Molecular changes in senile dementia. , 1973, Brain : a journal of neurology.

[187]  U. Brunk,et al.  Electron microscopical studies on rat brain neurons. Localization of acid phosphatase and mode of formation of lipofuscin bodies. , 1972, Journal of ultrastructure research.

[188]  N. Brachfeld Maintenance of Cell Viability , 1969 .

[189]  P. Timiras,et al.  The amount and distribution of pigments in neurons and glia of the cerebral cortex. Autofluorescent and ultrastructural studies. , 1969, Journal of gerontology.

[190]  C. Duve,et al.  Functions of lysosomes. , 1966, Annual review of physiology.

[191]  R. Terry,et al.  ULTRASTRUCTURAL STUDIES IN ALZHEIMER'S PRESENILE DEMENTIA. , 1964, The American journal of pathology.