A Quantitative Assessment of the Total Inward Leakage of NaCl Aerosol Representing Submicron-Size Bioaerosol Through N95 Filtering Facepiece Respirators and Surgical Masks

Respiratory protection provided by a particulate respirator is a function of particle penetration through filter media and through faceseal leakage. Faceseal leakage largely contributes to the penetration of particles through a respirator and compromises protection. When faceseal leaks arise, filter penetration is assumed to be negligible. The contribution of filter penetration and faceseal leakage to total inward leakage (TIL) of submicron-size bioaerosols is not well studied. To address this issue, TIL values for two N95 filtering facepiece respirator (FFR) models and two surgical mask (SM) models sealed to a manikin were measured at 8 L and 40 L breathing minute volumes with different artificial leak sizes. TIL values for different size (20–800 nm, electrical mobility diameter) NaCl particles representing submicron-size bioaerosols were measured using a scanning mobility particle sizer. Efficiency of filtering devices was assessed by measuring the penetration against NaCl aerosol similar to the method used for NIOSH particulate filter certification. Results showed that the most penetrating particle size (MPPS) was ∼45 nm for both N95 FFR models and one of the two SM models, and ∼350 nm for the other SM model at sealed condition with no leaks as well as with different leak sizes. TIL values increased with increasing leak sizes and breathing minute volumes. Relatively, higher efficiency N95 and SM models showed lower TIL values. Filter efficiency of FFRs and SMs influenced the TIL at different flow rates and leak sizes. Overall, the data indicate that good fitting higher-efficiency FFRs may offer higher protection against submicron-size bioaerosols.

[1]  Samy Rengasamy,et al.  Total inward leakage measurement of particulates for N95 filtering facepiece respirators--a comparison study. , 2014, The Annals of occupational hygiene.

[2]  Whole Grain Label Statements Guidance for Industry and FDA Staff , 2006 .

[3]  J. Siegel,et al.  HEALTH CARE INFECTION CONTROL PRACTICES ADVISORY COMMITTEE. 2007 GUIDELINE FOR ISOLATION PRECAUTIONS: PREVENTING TRANSMISSION OF INFECTIOUS AGENTS IN HEALTH CARE SETTINGS , 2007 .

[4]  Sylvia Chong,et al.  Surgical mask vs N95 respirator for preventing influenza among health care workers: a randomized trial. , 2009, JAMA.

[5]  Mary-Louise McLaws,et al.  Protecting healthcare workers from pandemic influenza: N95 or surgical masks? , 2010, Critical care medicine.

[6]  J. Peiris,et al.  Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS) , 2003, The Lancet.

[7]  J. Druce,et al.  A quantitative assessment of the efficacy of surgical and N95 masks to filter influenza virus in patients with acute influenza infection. , 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[8]  Don-Hee Han,et al.  Evaluation of particulate filtering respirators using inward leakage (IL) or total inward leakage (TIL) testing--Korean experience. , 2005, The Annals of occupational hygiene.

[9]  N. Fishman,et al.  Healthcare Infection Control Practices Advisory Committee , 2012 .

[10]  Benjamin J. Cowling,et al.  Influenza Virus in Human Exhaled Breath: An Observational Study , 2008, PloS one.

[11]  Tiina Reponen,et al.  Performance of an N95 Filtering Facepiece Particulate Respirator and a Surgical Mask During Human Breathing: Two Pathways for Particle Penetration , 2009, Journal of occupational and environmental hygiene.

[12]  C C Coffey,et al.  Performance of N95 respirators: filtration efficiency for airborne microbial and inert particles. , 1998, American Industrial Hygiene Association journal.

[13]  Samy Rengasamy,et al.  Filtration Performance of FDA-Cleared Surgical Masks. , 2009, Journal of the International Society for Respiratory Protection.

[14]  T. R. Peters,et al.  Transocular entry of seasonal influenza-attenuated virus aerosols and the efficacy of n95 respirators, surgical masks, and eye protection in humans. , 2011, The Journal of infectious diseases.

[15]  Y. Leo,et al.  The outbreak of SARS at Tan Tock Seng Hospital--relating epidemiology to control. , 2006, Annals of the Academy of Medicine, Singapore.

[16]  Lisa M Brosseau,et al.  Surgical mask filter and fit performance , 2008, American Journal of Infection Control.

[17]  Samy Rengasamy Nanoparticle Penetration through NIOSH-Approved N95 Filtering-facepiece Respirators , 2007 .

[18]  Y. Leo,et al.  Factors associated with transmission of severe acute respiratory syndrome among health-care workers in Singapore , 2004, Epidemiology and Infection.

[19]  憲 大久保 Guideline for isolation precautions: preventing transmission of infectious agents in healthcare settings 2007 , 2008 .

[20]  S. Walter,et al.  SARS among Critical Care Nurses, Toronto , 2004, Emerging infectious diseases.

[21]  E Newton,et al.  In vivo protective performance of N95 respirator and surgical facemask. , 2006, American journal of industrial medicine.

[22]  Gerhard Scheuch,et al.  Inhaling to mitigate exhaled bioaerosols. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[23]  Y Zhou,et al.  Face masks to prevent transmission of influenza virus: a systematic review , 2010, Epidemiology and Infection.

[24]  Linsey C Marr,et al.  Concentrations and size distributions of airborne influenza A viruses measured indoors at a health centre, a day-care centre and on aeroplanes , 2011, Journal of The Royal Society Interface.

[25]  Arjun Srinivasan,et al.  Hospital preparedness for severe acute respiratory syndrome in the United States: views from a national survey of infectious diseases consultants. , 2004, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[26]  C. Goodman,et al.  Food and Drug Administration Center for Devices and Radiological Health , 1988 .

[27]  Ismail Celik,et al.  Quantity and Size Distribution of Cough-Generated Aerosol Particles Produced by Influenza Patients During and After Illness , 2012, Journal of occupational and environmental hygiene.

[28]  Certifying Personal Protective Technologies: Improving Worker Safety , 2010 .

[29]  Samy Rengasamy,et al.  Nanoparticle penetration through filter media and leakage through face seal interface of N95 filtering facepiece respirators. , 2012, The Annals of occupational hygiene.

[30]  Tiina Reponen,et al.  Respiratory Performance Offered by N95 Respirators and Surgical Masks: Human Subject Evaluation with NaCl Aerosol Representing Bacterial and Viral Particle Size Range , 2008, The Annals of occupational hygiene.