Predicted infant exposure to tetrachloroethene in human breastmilk.

Based on a variety of maternal occupational and residential inhalation exposure scenarios, estimates of infant exposure to the dry-cleaning solvent tetrachlorothylene (perchloroethylene, PCE) in breastmilk were made. Physiologically based pharmacokinetic (PBPK) modeling indicates that infants may be exposed to elevated levels of PCE in breastmilk due to their mothers' inhalation of PCE. The PBPK-predicted breastmilk PCE concentrations agree very well with measured concentrations, where available. Based on this analysis, infants may be exposed to this workplace chemical via breastmilk at doses corresponding to rather high levels of risk. Predicted breastmilk doses provide the infant with little margin of exposure to doses associated with adverse health effects. In addition, the estimated increased cancer risks associated with these infant exposures are large under certain exposure scenarios. The actual concentrations of PCE in breastmilk of exposed mothers can only be known with certainty if monitoring is conducted. Due to the widespread exposure potential, monitoring studies should be undertaken so that the appropriate risk management alternatives can be better evaluated.

[1]  D. Jelliffe,et al.  Breast-feeding and health in the 1980s: a global epidemiologic review. , 1991, The Journal of pediatrics.

[2]  T. Keefe,et al.  National study of chlorinated hydrocarbon insecticide residues in human milk, USA. I. Geographic distribution of dieldrin, heptachlor, heptachlor epoxide, chlordane, oxychlordane, and mirex. , 1981, American journal of epidemiology.

[3]  C Cox,et al.  Worker exposure to perchloroethylene in the commercial dry cleaning industry. , 1983, American Industrial Hygiene Association journal.

[4]  A. A. Jensen.  Chemical Contaminants in Human Milk , 1990 .

[5]  A. Koizumi.  Potential of physiologically based pharmacokinetics to amalgamate kinetic data of trichloroethylene and tetrachloroethylene obtained in rats and man. , 1989, British journal of industrial medicine.

[6]  S. M. Lambert.  Hookworm disease in the South Pacific. Ten years of tetrachlorides. , 1933 .

[7]  D. H. Taylor,et al.  Physiologically based pharmacokinetic modeling of the lactating rat and nursing pup: a multiroute exposure model for trichloroethylene and its metabolite, trichloroacetic acid. , 1990, Toxicology and applied pharmacology.

[8]  D. M. Hetrick,et al.  Pharmacokinetics of tetrachloroethylene. , 1988, Toxicology and applied pharmacology.

[9]  J. Buben,et al.  Delineation of the role of metabolism in the hepatotoxicity of trichloroethylene and perchloroethylene: a dose-effect study. , 1985, Toxicology and applied pharmacology.

[10]  J S Schreiber,et al.  An investigation of indoor air contamination in residences above dry cleaners. , 1993, Risk analysis : an official publication of the Society for Risk Analysis.

[11]  E D Pellizzari,et al.  Effect of dry-cleaned clothes on tetrachloroethylene levels in indoor air, personal air, and breath for residents of several New Jersey homes. , 1991, Journal of exposure analysis and environmental epidemiology.

[12]  Z S Guo,et al.  The temperature dependence of the emission of perchloroethylene from dry cleaned fabrics. , 1990, Environmental research.

[13]  R. D. Waddell,et al.  Purgeable organic compounds in mother's milk , 1982, Bulletin of environmental contamination and toxicology.

[14]  J. Borzelleca,et al.  The subchronic toxicity of tetrachloroethylene (perchloroethylene) administered in the drinking water of rats. , 1986, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[15]  R. Wands,et al.  Identification and classification of carcinogens: procedures of the Chemical Substances Threshold Limit Value Committee, ACGIH. American Conference of Governmental Industrial Hygienists. , 1986, American journal of public health.

[16]  T Kawauchi,et al.  Residual tetrachloroethylene in dry-cleaned clothes. , 1989, Environmental research.

[17]  M E Andersen,et al.  An inhalation distribution model for the lactating mother and nursing child. , 1988, Toxicology letters.

[18]  C. Portier,et al.  Should the presence of carcinogens in breast milk discourage breast feeding? , 1991, Regulatory toxicology and pharmacology : RTP.

[19]  B C Gladen,et al.  Polychlorinated biphenyls (PCBs) and dichlorodiphenyl dichloroethene (DDE) in human milk: effects of maternal factors and previous lactation. , 1986, American journal of public health.

[20]  T E McKone,et al.  Linking indoor air and pharmacokinetic models to assess tetrachloroethylene risk. , 1988, Risk analysis : an official publication of the Society for Risk Analysis.

[21]  B L Materna,et al.  Occupational exposure to perchloroethylene in the dry cleaning industry. , 1985, American Industrial Hygiene Association journal.

[22]  W. Popp,et al.  Concentrations of tetrachloroethene in blood and trichloroacetic acid in urine in workers and neighbours of dry-cleaning shops , 1992, International archives of occupational and environmental health.