Screening scale predicts patients successfully receiving long-term implantable left ventricular assist devices.

BACKGROUND Although use of long-term implantable left ventricular assist devices (LVAD) is becoming more popular, further reduction of the mortality rate accompanying device insertion through improved patient selection would make this alternative even more appealing. We sought to develop a scoring system that was based on criteria obtainable at the time of evaluation and predictive of successful early outcome and simple to apply. METHODS AND RESULTS Patients (n = 56) undergoing LVAD insertion between 1990 and 1994 were screened for easily obtainable preoperative risk factors. To test the association between survival and each risk factor, a chi 2 analysis was performed, and relative risks were estimated. Oliguria, ventilator dependence, elevated central venous pressure, elevated prothrombin time, and reoperation stats had low probability values and high estimated relative risks. On the basis of these relations, a risk factor-selection scale (RFSS) (range, 0 to 10) was developed by computing appropriate weights for each risk factor. The distribution of patients for each scale score reveal that with RFSS > or = 5, most device recipients will die (P < .001). The average RFSS (+/- SD) of survivors (n = 42) was 2.45 +/- 1.73 compared with 5.43 +/- 2.85 in nonsurvivors (n = 14) (P < .0001). Univariate logistical regression was also significant (score statistic, 16.2; df = 1; P = .001). CONCLUSIONS The RFSS is simple, easy to apply, and statistically valid. Physicians could use the scale as a starting point in discussing the suitability for LVAD implantation in a specific patient and as a basis for comparing patient outcomes.

[1]  J. Wennberg,et al.  Multivariate Prediction of In‐Hospital Mortality Associated With Coronary Artery Bypass Graft Surgery , 1992 .

[2]  J R Wilson,et al.  Value of Peak Exercise Oxygen Consumption for Optimal Timing of Cardiac Transplantation in Ambulatory Patients With Heart Failure , 1991, Circulation.

[3]  J. C. Norman,et al.  Prognostic indices for survival during postcardiotomy intra-aortic balloon pumping. Methods of scoring and classification, with implications for left ventricular assist device utilization. , 1977, The Journal of thoracic and cardiovascular surgery.

[4]  D. Pennington,et al.  Bridge to heart transplantation: importance of patient selection. , 1990, The Journal of heart transplantation.

[5]  G. Noon,et al.  A model to predict survival at time of postcardiotomy intraaortic balloon pump insertion. , 1993, The Annals of thoracic surgery.

[6]  O H Frazier,et al.  Multicenter clinical evaluation of the HeartMate 1000 IP left ventricular assist device. , 1992, The Annals of thoracic surgery.

[7]  Helena C. Kraemer,et al.  Assessment of 2 × 2 Associations: Generalization of Signal-Detection Methodology , 1988 .

[8]  P M Portner,et al.  Clinical experience with the Novacor ventricular assist system. Bridge to transplantation and the transition to permanent application. , 1991, The Journal of thoracic and cardiovascular surgery.

[9]  J. Hanley,et al.  The meaning and use of the area under a receiver operating characteristic (ROC) curve. , 1982, Radiology.

[10]  D. Farrar Preoperative predictors of survival in patients with Thoratec ventricular assist devices as a bridge to heart transplantation. Thoratec Ventricular Assist Device Principal Investigators. , 1994, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.