论文信息 - Genetics in the Age of Systems Biology

Genetics in the Age of Systems Biology

Systems biology has become a fashionable label for a new generation of large-scale experiments. This essay explores how classical approaches such as forward genetics fit into this emerging framework.

Peter Robin Hiesinger | Bassem A. Hassan

[1] N. Perrimon,et al. Tailoring the genome: the power of genetic approaches , 2003, Nature Genetics.

[2] S. Brenner,et al. Mutations causing transformation of sexual phenotype in the nematode Caenorhabditis elegans. , 1977, Genetics.

[3] Clive Richards,et al. The Blind Watchmaker , 1987, Bristol Medico-Chirurgical Journal.

[4] C. Nüsslein-Volhard,et al. Mutations affecting segment number and polarity in Drosophila , 1980, Nature.

[5] R. Dawkins. The Blind Watchmaker , 1986 .

[6] Norbert Perrimon,et al. Genome-wide high-throughput screens in functional genomics. , 2004, Current opinion in genetics & development.

[7] B. Bainbridge,et al. Genetics , 1981, Experientia.

[8] Edison T Liu,et al. Systems Biology, Integrative Biology, Predictive Biology , 2005, Cell.

[9] Marc W Kirschner,et al. The Meaning of Systems Biology , 2005, Cell.

[10] Marc Vidal,et al. Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis , 2005, Nature.

[11] S. Benzer,et al. Mapping of Behaviour in Drosophila Mosaics , 1972, Nature.

[12] K. Nasmyth,et al. Novel Genes Required for Meiotic Chromosome Segregation Are Identified by a High-Throughput Knockout Screen in Fission Yeast , 2005, Current Biology.